This study reviewed reports of ankylosing spondylitis (AS) following vaccination by searching Scielo, PubMed, and Web of Science (1966–April 2024). Only two articles were found, encompassing 3,862,339 participants and 910 post-vaccination AS cases (793 after COVID-19 vaccines and 117 after other vaccines, including 22 following influenza vaccination). The mean age was 45.7 ± 18.7 years, and symptom onset occurred 2 (1–7) days post-vaccination. Preliminary evidence suggests vaccine induced AS, warranting standardized prospective research.
- Open Access
- Letter to the Editor
Ankylosing Spondylitis New-Onset Following Vaccination: A Review
- Jozélio Freire de Carvalho 1, *,
- Ana Tereza Amoedo Martinez 2
Author Information
Received: 23 Apr 2025 | Revised: 10 Jul 2025 | Accepted: 15 Jul 2025 | Published: 24 Jul 2025
Abstract
Keywords
ankylosing spondylitis | spondyloarthritis | vaccination | vaccine
References
- 1.Tishler, M.; Shoenfeld, Y. Vaccination may be associated with autoimmune diseases. Isr. Med. Assoc. J. 2004, 6, 430–432.
- 2.Bagcier, F.; Yurdakul, O.V.; Ozduran, E. Top 100 cited articles on ankylosing spondylitis. Reumatismo 2021, 72, 218–227.
- 3.Kim, S.; Bea, S.; Choe, S.A.; et al. Autoimmune disorders reported following COVID-19 vaccination: A disproportionality analysis using the WHO database. Eur. J. Clin. Pharmacol. 2024, 80, 445–453.
- 4.Ju, H.J.; Lee, J.Y.; Han, J.H.; et al. Risk of autoimmune skin and connective tissue disorders after mRNA-based COVID-19 vaccination. J. Am. Acad. Dermatol. 2023, 89, 685–693.
How to Cite
de Carvalho, J. F.; Martinez, A. T. A. Ankylosing Spondylitis New-Onset Following Vaccination: A Review. Journal of Mosaic of Autoimmunity 2025, 1 (1), 9. https://doi.org/10.53941/jmai.2025.100009.
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Copyright (c) 2025 by the authors.
This work is licensed under a Creative Commons Attribution 4.0 International License.
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