To achieve the goal of trace analysis in photoelectrochemical (PEC) sensing technology, the rational design of interface function materials to perform efficient target conversions and signal carrier transformations is an urgent need. As promising enzyme mimics, nanozymes enable the reproduction of the enzyme-induced catalytic amplification behaviors and have attracted much interest in sensing applications. Inheriting the merits of nanomaterial science, nanozymes overcome the limitation of poor electroconductivity and fragility of enzymes, showing enhanced and stable signal carrier transduction. More importantly, it brings more opportunities to regulate the carrier transport pathways to improve the signaling. Based on the pace of development in this field, this review provides an in-depth discussion of the signal amplification strategies according to the different functions of nanozymes, including catalyzing signal transduction and tuning carrier migrations. Then, combined with various analytic strategies, high-performance sensing applications were introduced. Furthermore, the challenges and future perspectives were proposed. We hope this review provides valuable information for researchers in related fields regarding the selection and modification strategies of nanozymes, thereby offering new insights for the development of advanced systems.



