Investigation Utilization of Medicinal Plants: From Historical Practices to Contemporary Medicine

Shaymaa Al-Majmaie; Rana H. Naser; Sarah H. Hadi; Abbas Murtadeh Ismail; Sushmita Nath

doi:10.53941/npa.2025.100004

Abstract

This study explores the use of medicinal plants from historical traditions within contemporary medical practice, highlighting their continued relevance across diverse cultures and healthcare systems. Indigenous populations and ancient civilizations employed botanical remedies to treat a wide spectrum of diseases, laying the foundation for traditional healing systems and contributing to empirical medical knowledge. To evaluate these practices in a modern context, a structured narrative review and data-driven synthesis were conducted. Data were retrieved from PubMed, Scopus, ScienceDirect, and Google Scholar, prioritizing publications from 2000–2024 while including earlier works for historical context. Sources were classified according to cultural significance and pharmacological validation. The synthesis identifies medicinal plants that are both culturally significant and pharmacologically substantiated. The findings demonstrate the renewed relevance of herbal therapies in integrative healthcare and underscore the importance of preserving traditional knowledge while ensuring rigorous, evidence-based validation. Overall, this study advocates for a comprehensive framework that bridges cultural heritage and modern biomedical practice to address contemporary health challenges.

References

1.
Stojanoski, N. Development of Health Culture in Veles and Its Region from the Past to the End of the 20th Century; Society of Science and Art: Veles, North Macedonia, 1999; Volume 13, p. 34.
2.
Jamshidi-Kia, F.; Lorigooini, Z.; Amini-Khoei, H. Medicinal plants: Past history and future perspective. J. Herbmed Pharmacol. 2017, 7, 1–7.
3.
Hamilton, A.C. Medicinal plants, conservation and livelihoods. Biodivers. Conserv. 2004, 13, 1477–1517.
4.
Halberstein, R.A. Medicinal plants: Historical and cross-cultural usage patterns. Ann. Epidemiol. 2005, 15, 686–699.
5.
Verma, S.; Singh, S.P. Current and future status of herbal medicines. Vet. World 2008, 1, 347.
6.
Phillipson, J.D. Phytochemistry and medicinal plants. Phytochemistry 2001, 56, 237–243.
7.
Sarker, S.D.; Nahar, L. An Introduction to Natural Products Isolation; Humana Press: Totowa, NJ, USA, 2012; pp. 1–25.
8.
Rasool Hassan, B.A. Medicinal plants (importance and uses). Pharm. Anal. Acta 2012, 3, 2153–2435.
9.
Al-Majmaie, S.; Nahar, L.; Rahman, M.M.; et al. Anti-MRSA constituents from Ruta chalepensis (Rutaceae) grown in Iraq, and in silico studies on two of most active compounds, chalepensin and 6-hydroxy-rutin 3′,7-dimethyl ether. Molecules 2021, 26, 1114.
10.
Nahar, L.; Al-Majmaie, S.; Al-Groshi, A.; et al. Chalepin and chalepensin: Occurrence, biosynthesis and therapeutic potential. Molecules 2021, 26, 1609.
11.
World Health Organization (WHO). WHO Traditional Medicine Strategy: 2014–2023; WHO Press: Geneva, Switzerland, 2013.
12.
Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J. Nat. Prod. 2020, 83, 770–803. https://doi.org/10.1021/acs.jnatprod.9b01285.
13.
World Health Organization. WHO Global Report on Traditional and Complementary Medicine 2019. Available online: https://www.who.int/publications/i/item/978924151536 (accessed on 28 July 2025).
14.
Altinoz, E., Taskin, E., Oner, Z.; et al. The role of African medicinal plants in traditional health care systems. Afr. J. Tradit. Complement. Altern. Med. 2015, 12, 1–13. https://doi.org/10.4314/ajtcam.v12i5.1.
15.
U.S. National Library of Medicine. Herbs and Supplements. 2020. Available online: https://medlineplus.gov/druginfo/herb_All.html (accessed on 28 July 2025).
16.
Veiga Junior, V.F.; Pinto, A.C. Brazilian biodiversity: A rich source of bioactive compounds. Braz. J. Pharmacogn. 2018, 28, 225–226. https://doi.org/10.1016/j.bjp.2018.04.003.
17.
European Medicines Agency. Herbal Medicines for Human Use. 2018. Available online: https://www.ema.europa.eu/en/human-regulatory/herbal-products/herbal-medicines (accessed on 28 July 2025).
18.
Australian Government Department of Health. Complementary Medicines Assessed Listed Pathway; Therapeutic Goods Administration: Woden, ACT, Australia, 2017.
19.
Kelly, K. History of Medicine; Facts on File: New York, NY, USA, 2009; pp. 29–50.
20.
Bottcher, H. Miracle Drugs; Zora: Zagreb, Croatia, 1965; pp. 23–139.
21.
Wiart, C. Ethnopharmacology of Medicinal Plants; Humana Press: Totowa, NJ, USA, 2006; pp. 1–50.
22.
Bojadzievski, P. The Health Services in Bitola through the Centuries; Society of Science and Art: Bitola, North Macedonia, 1992; pp. 15–27.
23.
Toplak Galle, K. Domestic Medicinal Plants; Mozaic Book: Zagreb, Croatia, 2005; pp. 60–61.
24.
Kiple, K.F.; Ornelas, K.C. The Cambridge World History of Food; Cambridge University Press: Cambridge, UK, 2000.
25.
Touwaide, A.; Appetiti, E. Food and medicines in the Mediterranean tradition: A systematic analysis of the earliest extant body of textual evidence. J. Ethnopharmacol. 2010, 132, 1–13. https://doi.org/10.1016/j.jep.2010.04.008.
26.
Qiao, J.; Lu, G.; Wu, G.; et al. Influence of different pretreatments and drying methods on the chemical compositions and bioactivities of Smilacis Glabrae Rhizoma. Chin. Med. 2022, 17, 54
27.
Cao, R.; Li, X.; Zhang, Y.; et al. Drying kinetics and alkaloid stability in Uncariae Ramulus Cum Uncis and links to anticoagulating activity. J. Ethnopharmacol. 2024, 320, 117856. https://doi.org/10.1016/j.jep.2024.117856.
28.
Vaou, N.; Stavropoulou, E.; Voidarou, C.; et al. Towards advances in medicinal plant antimicrobial activity: A review study on challenges and future perspectives. Microorganisms 2021, 9, 2041.
29.
Al-Majmaie, S.; Nahar, L.; Sharples, G.P.; et al. Isolation and antimicrobial activity of rutin and its derivatives from Ruta chalepensis (Rutaceae) growing in Iraq. Rec. Nat. Prod. 2019, 13, 64–70.
30.
Bahall, M.; Legall, G. Knowledge, attitudes, and practices among health care providers regarding complementary and alternative medicine in Trinidad and Tobago. BMC Complement. Altern. Med. 2017, 17, 144.
31.
Hefferon, K. Plant-derived pharmaceuticals for the developing world. Biotechnol. J. 2013, 8, 1193–1202.
32.
Veeresham, C. Natural products derived from plants as a source of drugs. J. Adv. Pharm. Technol. Res. 2012, 3, 200–201.
33.
Kurek-Gorecka, A.; Walczyńska-Dragon, K.; Felitti, R.; et al. The influence of propolis on dental plaque reduction and the correlation between dental plaque and severity of COVID-19 complications—A literature review. Molecules 2021, 26, 5516.
34.
Surjushe, A.; Vasani, R.; Saple, D.G. Aloe vera: A short review. Indian J. Dermatol. 2008, 53, 163–166.
35.
Hewlings, S.J.; Kalman, D.S. Curcumin: A review of effects on human health. Foods 2017, 6, 92.
36.
Bayan, L.; Koulivand, P.H.; Gorji, A. Garlic: A review of therapeutic effects. Avicenna J. Phytomed. 2014, 4, 1–14.
37.
Mashhadi, N.S.; Ghiasvand, R.; Askari, G.; et al. Ginger in health and physical activity. Int. J. Prev. Med. 2013, 4, S36–S42.
38.
McKay, D.L.; Blumberg, J.B. Health benefits of peppermint tea. Phytother. Res. 2006, 20, 619–633.
39.
Reay, J.L.; Kennedy, D.O.; Scholey, A.B. Effects of Panax ginseng on cognitive performance. Psychopharmacology 2005, 172, 386–392.
40.
Srivastava, J.K.; Shankar, E.; Gupta, S. Chamomile: A herbal medicine of the past with bright future. Mol. Med. Rep. 2010, 3, 895–901.
41.
Asl, M.N.; Hosseinzadeh, H. Pharmacological effects of Glycyrrhiza glabra L. (Licorice): A review. Phytother. Res. 2008, 22, 709–724.
42.
Barnes, J.; Anderson, L.A.; Gibbons, S. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): A review of their chemistry, pharmacology and clinical properties. J. Pharm. Pharmacol. 2005, 57, 929–954.
43.
Subapriya, R.; Nagini, S. Medicinal properties of neem (Azadirachta indica): A review. Curr. Med. Chem. Anti-Cancer Agents 2005, 5, 149–156.
44.
Deutch, C.E. Limited effectiveness of over-the-counter plant preparations used for the treatment of urinary tract infections as inhibitors of the urease activity from Staphylococcus saprophyticus. J. Appl. Microbiol. 2017, 122, 1380–1388.
45.
Calixto, J.B. Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents). Braz. J. Med. Biol. Res. 2000, 33, 179–189.
46.
WHO. WHO Global Report on Traditional and Complementary Medicine 2019; World Health Organization: Geneva, Switzerland, 2021.
47.
Ekor, M. The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Front. Pharmacol. 2014, 4, 177. https://doi.org/10.3389/fphar.2013.00177.
48.
Ríos, J.L.; Recio, M.C. Medicinal plants and antimicrobial activity. J. Ethnopharmacol. 2005, 100, 80–84.
49.
Njume, C.; Goduka, N.I. Treatment of diarrhoea in rural African communities: An overview of measures to maximise the medicinal potentials of indigenous plants. Int. J. Environ. Res. Public Health 2012, 9, 3911–3933.
50.
Radulović, N.S.; Blagojević, P.D.; Stojanović-Radić, Z.Z.; et al. Antimicrobial plant metabolites: Structural diversity and mechanism of action. Curr. Med. Chem. 2013, 20, 932–952.
51.
Heinrich, M.; Appendino, G.; Efferth, T.; et al. Best practice in research: Consensus statement on ethnopharmacological field studies. J. Ethnopharmacol. 2022, 284, 114799. https://doi.org/10.1016/j.jep.2021.114799.
52.
Alallaq, S.A.; Murtadeh, I.A.; Al-Majmaie, S.H. Determination of Alkaloids Constituents in Some Ferns by Using High Performance Liquid Chromatography Technique–Iraq. Iraqi J. Sci. 2023, 64, 4340–4346.
53.
Al-Majmaie, S.; Alwan, A.M.; Nath, S.; et al. Investigation of antimicrobial activity of Aloe vera (L). burm. F. leaf gel, Punica granatum L., ricinus communisl and Musa sp. extracts. In AIP Conference Proceedings; AIP Publishing LLC: Melville, NY, USA, 2023; Volume 2845, p. 040006.
54.
Pandey, M.M.; Rastogi, S.; Rawat, A.K. Plant-derived bioactives: Applications in health care and agriculture. Plant Biotechnol. Rep. 2020, 14, 491–512. https://doi.org/10.1007/s11816-020-00637-9.
55.
Rodrigues, E.; Barnes, J. Pharmacovigilance of herbal medicines: The potential contributions of ethnobotanical and ethnopharmacological studies. Drug Saf. 2013, 36, 1–12.
56.
Li, S.; Zhang, B.; Jiang, D.; et al. Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae. Sci. Rep. 2019, 9, 1–13. https://doi.org/10.1038/s41598-019-51172-3.
57.
EMA. Guideline on Quality of Herbal Medicinal Products/Traditional Herbal Medicinal Products; European Medicines Agency: Amsterdam, The Netherlands, 2021.
58.
Wang, X.; Zhang, Y.; Yang, X.; et al. Advances in herbal medicine nanoformulations: A promising approach for clinical application. J. Nanobiotechnol. 2020, 18, 57. https://doi.org/10.1186/s12951-020-00610-3.
59.
Ghosh, S.; Mandi, A.; Jha, T.B. Plant biotechnology for production of bioactive compounds: Progress and future prospects. Biotechnol. Adv. 2021, 50, 107769. https://doi.org/10.1016/j.biotechadv.2021.107769.
60.
Grand View Research. Herbal Medicine Market Size, Share & Trends Analysis Report by Product, by Application, by Region, and Segment Forecasts, 2022–2030. 2022. Available online: https://www.grandviewresearch.com/industry-analysis/herbal-medicine-market (accessed on).
61.
Savoia, D. Plant-derived antimicrobial compounds: Alternatives to antibiotics. Future Microbiol. 2012, 7, 979–990.
62.
Gurib-Fakim, A. Medicinal plants: Traditions of yesterday and drugs of tomorrow. Mol. Asp. Med. 2006, 27, 1–93. https://doi.org/10.1016/j.mam.2005.07.008.
63.
Huie, C.W. A review of modern sample-preparation techniques for the extraction and analysis of medicinal plants. Anal. Bioanal. Chem. 2002, 373, 23–30.

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