Everyday discrimination significantly predicts psychological distress among international medical students, a growing yet understudied population in Arab contexts. This mixed-methods cross-sectional study assessed discrimination prevalence and its mental health impact in 391 students at Ain Shams University, Egypt, Data collection was conducted between September 2025 to December 2025, using the Everyday Discrimination Scale (EDS), General Health Questionnaire-12 (GHQ-12), sociodemographic survey, and two focus group discussions (FGDs) with 20 participants; quantitative data underwent non-parametric analyses, while qualitative data used thematic analysis. Nearly half (47.6%) reported discrimination (median EDS score 9.0, IQR 4–21), predominantly verbal (26.1%) and skin color-based (20.1%), with higher EDS scores correlating to greater distress (Spearman’s rho = 0.394, p < 0.001; median GHQ-12 = 12, IQR 8–18); females and first-years showed elevated levels (p < 0.001, p = 0.032). FGDs revealed themes of unequal treatment, emotional toll, coping via peer support, and needs for anti-bias training. Discrimination imposes a substantial psychological burden on international medical students in Egypt, especially newcomers and females, necessitating institutional mental health supports and equity policies.



