An 81-year-old man presented with weight loss and lymphocytosis with a white blood cell count of 55,000/µL with 80% lymphocytosis and 20% segmented neutrophils. Hemoglobin was 14 g/dL and platelets 139 × 103/µL. In flowcytometric analysis of peripheral blood, the CD19-expressing lymphocytes (52%) were positive for CD5, CD23, and CD200 and they were negative for CD10, CD103, CD25, and T-cell markers. There was no surface expression of light chains. Serum protein electrophoresis revealed mild hypogammaglobulinemia (0.60 g/dL, normal >0.69) and on immunofixation electrophoresis there was a small monoclonal spike of IgG Lambda.
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Intracellular Crystals in Chronic Lymphocytic Leukemia
- Sarvari Yellapragada,
- Perumal Thiagarajan *
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Received: 02 Dec 2024 | Accepted: 09 Jan 2025 | Published: 01 Mar 2025
Abstract
References
- 1.De Man, J.C.; Meiners, W.B. Crystals of protein nature in the cytoplasm of lymphatic cells in a case of lymphoreticular malignancy. Blood 1962, 20, 492–500.
- 2.Dorion, R.P.; Shaw, J.H. Intracytoplasmic filamentous inclusions in the peripheral blood of a patient with chronic lymphocytic leukemia. A bright-field, electron microscopic, immunofluorescent, and flow cytometric study. Arch. Pathol. Lab. Med. 2003, 127, 618–620.
- 3.Hao, J.; Gao, J.; Yang, Y.; An, Z.; Lian, X. "Rod-like" cytoplasmic crystals of peripheral lymphocytes in chronic lymphocytic leukemia. Turk. J. Haematol. 2023, 40, 202–203.
How to Cite
Yellapragada, S.; Thiagarajan, P. Intracellular Crystals in Chronic Lymphocytic Leukemia. International Journal of Clinical and Translational Medicine 2025, 1 (1), 7. https://doi.org/10.53941/ijctm.2025.100007.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
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