Physalis angulata L. family Solanaceae, commonly known as ground cherry, cape gooseberry, or bladder cherry, has a long history of traditional use in various regions around the world. The primary goal of this study is to investigate the different pharmacological effects produced by the ethanolic leaf extracts of Physalis angulata. The leaf extract was prepared in two different dosages: 250 mg/kg body weight and 500 mg/kg body weight, which were administered according to the body weight of the mice. In yeast-induced pyrexia in mice, after 4 h, positive control (Paracetamol 150 mg/kg), Physalis angulata 250 mg/kg, Physalis angulata 500 mg/kg expressed temperature were 98.78 ± 0.051 °F, 97.4 ± 0.213 °F and 96.56 ± 0.177 °F respectively. In the evaluation of acetic acid-induced peripheral analgesic activity, P. angulata extract exhibited 43% and 63% inhibition of writhing at 250 mg/kg and 500 mg/kg body weight, respectively. Whereas the standard Diclofenac-Na inhibited 76% at a dose of 25 mg/kg body weight. In castor oil-induced diarrhea, plant extract inhibited defecation by 59.65% at 250 mg/kg body weight and 72.45% at 500 mg/kg b.w., whereas standard loperamide at a dose of 3 mg/kg b.w. inhibited 83.50% of defecation. Ethanolic extract of Physalis angulata at the dose of 300 mg/kg, 2000 mg/kg and 5000 mg/kg showed average weight 21.2 ± 1.56 gm, 21.8 ± 0.82 gm and 24.45 ± 1.51 gm respectively at 2nd day. The disc diffusion method has been adopted for the evaluation of antimicrobial activity. The ethanolic extracts of Physalis angulata leaf exhibited inhibitory activity against fourteen strains, including Bacillus megaterium, Salmonella paratyphi, Candida aibicans, Vibrio mimicus, and Staphylococcus aureus.