Dosage Limits of Three Multifunctional Savannah Plants and Their Effects on Haematological Parameters of Albino Rats

Anthony Wale Ojewumi; Abdullahi Adeyemi Adegoke; Gabriel A. Dedeke

doi:10.53941/jmnp.2025.100017

Abstract

This study evaluated dosage limits of Eucalyptus camaldulensis, Hibiscus sabdariffa and Morinda lucida leaf, stem and root aqueous extracts on haematological parameters of 140 albino rats grouped into ten of five replications in a completely randomized design. Aqueous extract of 75 g, 100 g, and 125 g of three parts of the three plants were prepared separately by boiling with 1 L of water for 1 h. 1 mg/kg of the extracts was administered on the rats once daily for 30 days. Distilled water served as control. Weights of the rats were estimated while heamatological parameters were determined using ELISA kits. Pack cell volume (45.33%), mean cell haemoglobin concentration (34.11 g/dL) and mean cell haemoglobin (19.00 Pg) were higher in rats dosed 125 g/L H. sabdariffa leaf extract. Similar significant increase was observed in haemoglobin (16.12 g/dL) and red blood cell (8.97 × 10¹²/L) of the rats dosed 125 g/L H. sabdariffa stem extract, as well as white blood cell (30.23 × 10⁹/L) in rats dosed with M. lucida stem aqueous extract.100 g/L of H. sabdariffa extracts improved weights and haeamatology of the rats, hence, the dosage is recommended.

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