Polymer Microfibers: Fabrication, Structural Design, Functionalization, and Biomedical Applications

Bidya Mondal; S. M. Shatil Shahriar; Syed Muntazir Andrabi; Jingwei Xie

doi:10.53941/mi.2026.100009

Abstract

Microfibers are rapidly emerging as versatile building blocks for next-generation biomedical devices due to their precisely tunable morphology, chemistry, and functionality. However, most existing reviews primarily focus on electrospun nanofibers or broadly discuss nanofiber systems, where the focus on microfiber areas is limited. Herein, this review presents a comprehensive and systematic roadmap for the design and fabrication of microfibers tailored for healthcare applications. We first survey state-of-the-art fabrication technologies emphasizing their respective capabilities in controlling fiber diameter, alignment, internal architecture, and production throughput. We then discuss material selection strategies encompassing natural, synthetic, and hybrid composite systems. Subsequently, we examine key structural motifs, and elucidate how architectural design governs mass transport, cell-fiber interactions, and spatiotemporally controlled therapeutic release. We further outline functionalization strategies that transform passive microfibers into smart platforms. Finally, we highlight representative biomedical applications with high translational potential and commercial microfiber-based products. We conclude by discussing current translational challenges and future perspectives. Thus, this review provides practical design principles and strategic insights to accelerate the development and clinical translation of microfiber-based biomedical technologies.

References

1.
Xue, J.; Niu, Y.; Gong, M.; Shi, R.; Chen, D.; Zhang, L.; Lvov, Y. Electrospun Microfiber Membranes Embedded with Drug-Loaded Clay Nanotubes for Sustained Antimicrobial Protection. ACS Nano 2015, 9, 1600–1612.
2.
Haynl, C.; Hofmann, E.; Pawar, K.; Förster, S.; Scheibel, T. Microfluidics-Produced Collagen Fibers Show Extraordinary Mechanical Properties. Nano Lett. 2016, 16, 5917–5922.
3.
Wei, D.; Charlton, L.; Glidle, A.; Qi, N.; Dobson, P.S.; Dalby, M.J.; Fan, H.; Yin, H. Dynamically Modulated Core-Shell Microfibers to Study the Effect of Depth Sensing of Matrix Stiffness on Stem Cell Fate. ACS Appl. Mater. Interfaces 2021, 13, 37997–38006.
4.
Lanno, G.M.; Ramos, C.; Preem, L.; Putrins, M.; Laidmaë, I.; Tenson, T.; Kogermann, K. Antibacterial Porous Electrospun Fibers as Skin Scaffolds for Wound Healing Applications. ACS Omega 2020, 5, 30011–30022.
5.
Kong, B.; Liu, R.; Guo, J.; Lu, L.; Zhou, Q.; Zhao, Y. Tailoring Micro/Nano-Fibers for Biomedical Applications. Bioact. Mater. 2023, 19, 328–347.
6.
Daniele, M.A.; Boyd, D.A.; Adams, A.A.; Ligler, F.S. Microfluidic Strategies for Design and Assembly of Microfibers and Nanofibers with Tissue Engineering and Regenerative Medicine Applications. Adv. Healthc. Mater. 2015, 4, 11–28.
7.
Drotlef, D.M.; Amjadi, M.; Yunusa, M.; Sitti, M. Bioinspired Composite Microfibers for Skin Adhesion and Signal Amplification of Wearable Sensors. Adv. Mater. 2017, 29, 1701353.
8.
Lee, W.; Choi, J.H.; Lee, S.; Song, J.E.; Khang, G. Fabrication and Characterization of Silk Fibroin Microfiber-Incorporated Bone Marrow Stem Cell Spheroids to Promote Cell-Cell Interaction and Osteogenesis. ACS Omega 2020, 5, 18021–18027.
9.
Guo, W.; Zhang, X.; Yu, X.; Wang, S.; Qiu, J.; Tang, W.; Li, L.; Liu, H.; Wang, Z.L. Self-Powered Electrical Stimulation for Enhancing Neural Differentiation of Mesenchymal Stem Cells on Graphene-Poly(3,4-Ethylenedioxythiophene) Hybrid Microfibers. ACS Nano 2016, 10, 5086–5095.
10.
Fioretta, E.S.; Simonet, M.; Smits, A.I.P.M.; Baaijens, F.P.T.; Bouten, C.V.C. Differential Response of Endothelial and Endothelial Colony Forming Cells on Electrospun Scaffolds with Distinct Microfiber Diameters. Biomacromolecules 2014, 15, 821–829.
11.
Salas-Ambrosio, P.; Morales-Patlan, E.; Cedillo-Servin, G.; Tronnet, A.; Villavicencio, K.P.; Gómez-Lizárraga, K.; Benítez-Martínez, J.A.; Sanchez-Arevalo, F.M.; Velasquillo, C.; Ceapă, C.D.; et al. Electrospinning Lysine-Polypeptide Copolymers: Creating Microfiber Meshes for Biomedical Applications. ACS Appl. Polym. Mater. 2024, 6, 8733–8744.
12.
Zhu, J.; Zhu, Y.; Ye, Y.; Qiu, Z.; Zhang, Y.; Yu, Z.; Sun, X.; Bressler, D.C.; Jiang, F. Superelastic and Ultralight Aerogel Assembled from Hemp Microfibers. Adv. Funct. Mater. 2023, 33, 2300893.
13.
Lim, J.; Choi, G.; Joo, K.Il; Cha, H.J.; Kim, J. Embolization of Vascular Malformations via In Situ Photocrosslinking of Mechanically Reinforced Alginate Microfibers Using an Optical-Fiber-Integrated Microfluidic Device. Adv. Mater. 2021, 33, 2006759.
14.
Paxton, N.C.; Luposchainsky, S.; Reizabal, A.; Saiz, P.G.; Bade, S.; Woodruff, M.A.; Dalton, P.D. Manufacture of Biomimetic Auricular Surgical Implants Using 3D Printed High Density Polyethylene Microfibers. Adv. Mater. Technol. 2024, 9, 2301190.
15.
Huynh, V.L.; Trung, T.Q.; Meeseepong, M.; Lee, H.B.; Nguyen, T.D.; Lee, N.E. Hollow Microfibers of Elastomeric Nanocomposites for Fully Stretchable and Highly Sensitive Microfluidic Immunobiosensor Patch. Adv. Funct. Mater. 2020, 30, 2004684.
16.
Barroso-Solares, S.; Cuadra-Rodriguez, D.; Rodriguez-Mendez, M.L.; Rodriguez-Perez, M.A.; Pinto, J. A New Generation of Hollow Polymeric Microfibers Produced by Gas Dissolution Foaming. J. Mater. Chem. B 2020, 8, 8820–8829.
17.
Varadharajan Idhaiam, K.S.; Oporto, G.; Barre, M.; Terada, M.; Boyd, J.; Goldsmith, W.; Nurkiewicz, T.; Gupta, R.K.; Sabolsky, E.M. Eco-Friendly Hierarchical Nanoporous Microfiber Respirator Filters Fabricated Using Rotary Jet Spinning Technology (RJS). ACS Appl. Polym. Mater. 2023, 5, 1657–1669.
18.
Ma, W.; Liu, D.; Ling, S.; Zhang, J.; Chen, Z.; Lu, Y.; Xu, J. High-Throughput and Controllable Fabrication of Helical Microfibers by Hydrodynamically Focusing Flow. ACS Appl. Mater. Interfaces 2021, 13, 59392–59399.
19.
Pham, Q.P.; Sharma, U.; Mikos, A.G. Electrospun Poly (ε-Caprolactone) Microfiber and Multilayer Nanofiber/Microfiber Scaffolds: Characterization of Scaffolds and Measurement of Cellular Infiltration. Biomacromolecules 2006, 7, 2796–2805.
20.
Yu, Y.; Wei, W.; Wang, Y.; Xu, C.; Guo, Y.; Qin, J. Simple Spinning of Heterogeneous Hollow Microfibers on Chip. Adv. Mater. 2016, 28, 6649–6655.
21.
Ding, C.; Breunig, M.; Timm, J.; Marschall, R.; Senker, J.; Agarwal, S. Flexible, Stable, Mechanically, Porous Self-Standing Microfiber Network Membranes of Covalent Organic Frameworks: Preparation Method and Characterization. Adv. Funct. Mater. 2021, 31, 2106507.
22.
Shahriar, S.M.S.; Andrabi, S.M.; Al-Gahmi, A.M.; Yan, Z.; McCarthy, A.D.; Wang, C.; Yusuf, Z.A.; Sharma, N.S.; Busquets, M.E.; Nilles, M.I.; et al. Bicomponent Nano- and Microfiber Aerogels for Effective Management of Junctional Hemorrhage. Nat. Commun. 2025, 16, 2403.
23.
Gong, J.; Schuurmans, C.C.L.; van Genderen, A.M.; Cao, X.; Li, W.; Cheng, F.; He, J.J.; López, A.; Huerta, V.; Manríquez, J.; et al. Complexation-Induced Resolution Enhancement of 3D-Printed Hydrogel Constructs. Nat. Commun. 2020, 11, 1267.
24.
Roman, J.A.; Reucroft, I.; Martin, R.A.; Hurtado, A.; Mao, H.Q. Local Release of Paclitaxel from Aligned, Electrospun Microfibers Promotes Axonal Extension. Adv. Healthc. Mater. 2016, 5, 2628–2635.
25.
Calejo, I.; Costa-Almeida, R.; Reis, R.L.; Gomes, M.E. A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon-to-Bone Interface Gradient Scaffolds. Adv. Healthc. Mater. 2019, 8, 1900200.
26.
Kim, B.J.; Choi, J.Y.; Choi, H.; Han, S.; Seo, J.; Kim, J.; Joo, S.; Kim, H.M.; Oh, C.; Hong, S.; et al. Astrocyte-Encapsulated Hydrogel Microfibers Enhance Neuronal Circuit Generation. Adv. Healthc. Mater. 2020, 9, 1901072.
27.
Ning, H.; Wu, X.; Wu, Q.; Yu, W.; Wang, H.; Zheng, S.; Chen, Y.; Li, Y.; Su, J. Microfiber-Reinforced Composite Hydrogels Loaded with Rat Adipose-Derived Stem Cells and BMP-2 for the Treatment of Medication-Related Osteonecrosis of the Jaw in a Rat Model. ACS Biomater. Sci. Eng. 2019, 5, 2430–2443.
28.
Daniele, M.A.; North, S.H.; Naciri, J.; Howell, P.B.; Foulger, S.H.; Ligler, F.S.; Adams, A.A. Rapid and Continuous Hydrodynamically Controlled Fabrication of Biohybrid Microfibers. Adv. Funct. Mater. 2013, 23, 698–704.
29.
Patil, P.; Szymanski, J.M.; Feinberg, A.W. Defined Micropatterning of ECM Protein Adhesive Sites on Alginate Microfibers for Engineering Highly Anisotropic Muscle Cell Bundles. Adv. Mater. Technol. 2016, 1, 1600003.
30.
Tian, L.; Shi, J.; Li, W.; Zhang, Y.; Gao, X. Hollow Microfiber Assembly-Based Endocrine Pancreas-on-a-Chip for Sugar Substitute Evaluation. Adv. Healthc. Mater. 2024, 13, 2302104.
31.
Adamo, A.; Bartolacci, J.G.; Pedersen, D.D.; Traina, M.G.; Kim, S.; Pantano, A.; Ghersi, G.; Watkins, S.C.; Wagner, W.R.; Badylak, S.F.; et al. Continuous Microfiber Wire Mandrel-Less Biofabrication for Soft Tissue Engineering Applications. Adv. Healthc. Mater. 2022, 11, 2102613.
32.
Chen, J.; Zhao, X.; Qiao, L.; Huang, Y.; Yang, Y.; Chu, D.; Guo, B. Multifunctional On-Demand Removability Hydrogel Dressing Based on in Situ Formed AgNPs, Silk Microfibers and Hydrazide Hyaluronic Acid for Burn Wound Healing. Adv. Healthc. Mater. 2024, 13, 2303157.
33.
McNamara, M.C.; Aykar, S.S.; Alimoradi, N.; Niaraki Asli, A.E.; Pemathilaka, R.L.; Wrede, A.H.; Montazami, R.; Hashemi, N.N. Behavior of Neural Cells Post Manufacturing and After Prolonged Encapsulation within Conductive Graphene-Laden Alginate Microfibers. Adv. Biol. 2021, 5, 2101026.
34.
Li, R.; McCarthy, A.; Zhang, Y.S.; Xie, J. Decorating 3D Printed Scaffolds with Electrospun Nanofiber Segments for Tissue Engineering. Adv. Biosyst. 2019, 3, 1900137.
35.
Sharifi, S.; Sharifi, H. Electrospun-Reinforced Suturable Biodegradable Artificial Cornea. ACS Appl. Bio Mater. 2022, 5, 5716–5727.
36.
Mondal, B.; Saini, D.; Mishra, H.K.; Mandal, D. Internet of Things and Machine Learning Enabled Smart E-Textile with Exceptional Breathability for Point-of-Care Diagnostics. Adv. Mater. Technol. 2024, 2400206.
37.
Acik, G.; Altinkok, C. Polypropylene Microfibers via Solution Electrospinning under Ambient Conditions. J. Appl. Polym. Sci. 2019, 136, 48199.
38.
Kidoaki, S.; Kwon, I.K.; Matsuda, T. Mesoscopic Spatial Designs of Nano- and Microfiber Meshes for Tissue-Engineering Matrix and Scaffold Based on Newly Devised Multilayering and Mixing Electrospinning Techniques. Biomaterials 2005, 26, 37–46.
39.
Devolder, R.J.; Bae, H.; Lee, J.; Kong, H. Directed Blood Vessel Growth Using an Angiogenic Microfiber/Microparticle Composite Patch. Adv. Mater. 2011, 23, 3139–3143.
40.
Givens, S.R.; Gardner, K.H.; Rabolt, J.F.; Chase, D.B. High-Temperature Electrospinning of Polyethylene Microfibers from Solution. Macromolecules 2006, 40, 608–610.
41.
Vaseashta, A. Controlled Formation of Multiple Taylor Cones in Electrospinning Process. Appl. Phys. Lett. 2007, 90, 093115.
42.
Sun, D.; Chang, C.; Li, S.; Lin, L. Near-Field Electrospinning. Nano Lett. 2006, 6, 839–842.
43.
Mondal, B.; Sarkar, R.; Saini, D.; Gupta, V.; Kundu, T.K.; Mandal, D. All-Electrospun, Water-Resistant, Breathable. Wearable, and Stable Metal Halide Perovskite Engineered Electroactive Polymer Textiles for Flexible Piezoelectric Nanogenerator. Adv. Mater. Technol. 2023, 8, 2300614.
44.
Ura, D.P.; Rosell-Llompart, J.; Zaszczyńska, A.; Vasilyev, G.; Gradys, A.; Szewczyk, P.K.; Knapczyk-Korczak, J.; Avrahami, R.; Šišková, A.O.; Arinstein, A.; et al. The Role of Electrical Polarity in Electrospinning and on the Mechanical and Structural Properties of As-Spun Fibers. Materials 2020, 13, 4169.
45.
Shao, H.; Fang, J.; Wang, H.; Lin, T. Effect of Electrospinning Parameters and Polymer Concentrations on Mechanical-to-Electrical Energy Conversion of Randomly-Oriented Electrospun Poly(Vinylidene Fluoride) Nanofiber Mats. RSC Adv. 2015, 5, 14345–14350.
46.
Chi, H.; Jiang, A.; Wang, X.; Chen, G.; Song, C.; Prajapati, R.K.; Li, A.; Li, Z.; Li, J.; Zhang, Z.; et al. Dually Optimized Polycaprolactone/Collagen I Microfiber Scaffolds with Stem Cell Capture and Differentiation-Inducing Abilities Promote Bone Regeneration. J. Mater. Chem. B 2019, 7, 7052–7064.
47.
Fang, J.; Niu, H.; Wang, H.; Wang, X.; Lin, T. Enhanced Mechanical Energy Harvesting Using Needleless Electrospun Poly(Vinylidene Fluoride) Nanofibre Webs. Energy Environ. Sci. 2013, 6, 2196–2202.
48.
Wu, X.; Wang, Z.; Teng, J.; Yang, L.; Xu, S.; Luo, S.; Wu, Z.; Ye, C. Electrospun Microfiber Composite Scaffolds of Polyvinyl Alcohol, Polyhydroxybutyrate, and Multiwalled Carbon Nanotubes for Enhancing the Osteogenic Differentiation of Stem Cells to Promote Bone Regeneration. Int. J. Biol. Macromol. 2025, 309, 142988.
49.
Adhikary, P.; Biswas, A.; Mandal, D. Improved Sensitivity of Wearable Nanogenerators Made of Electrospun Eu³⁺ Doped P(VDF-HFP)/Graphene Composite Nanofibers for Self-Powered Voice Recognition. Nanotechnology 2016, 27, 495501.
50.
Schönlein, R.; Larrañaga, X.; Panfilo, A.; Li, Y.; Larrañaga, A.; Liu, G.; Müller, A.J.; Aguirresarobe, R.; Ugartemendia, J.M. Enhanced Piezoelectric Properties of Poly(L-Lactide) Nanocomposite Microfiber Scaffolds Due to Polydopamine-Coating of Barium Titanate Nanoparticles. Adv. Mater. Interfaces 2025, 12, 2400546.
51.
Mares-Bou, S.; Serrano, M.A.; Gómez-Tejedor, J.A. Core–Shell Polyvinyl Alcohol (PVA) Base Electrospinning Microfibers for Drug Delivery. Polymers 2023, 15, 1554.
52.
Li, Y.F.; Rubert, M.; Aslan, H.; Yu, Y.; Howard, K.A.; Dong, M.; Besenbacher, F.; Chen, M. Ultraporous Interweaving Electrospun Microfibers from PCL–PEO Binary Blends and Their Inflammatory Responses. Nanoscale 2014, 6, 3392–3402.
53.
Steffi, C.; Wang, D.; Kong, C.H.; Wang, Z.; Lim, P.N.; Shi, Z.; San Thian, E.; Wang, W. Estradiol-Loaded Poly(ε-Caprolactone)/Silk Fibroin Electrospun Microfibers Decrease Osteoclast Activity and Retain Osteoblast Function. ACS Appl. Mater. Interfaces 2018, 10, 9988–9998.
54.
Guo, Y.; Gilbert-Honick, J.; Somers, S.M.; Mao, H.Q.; Grayson, W.L. Modified Cell-Electrospinning for 3D Myogenesis of C2C12s in Aligned Fibrin Microfiber Bundles. Biochem. Biophys. Res. Commun. 2019, 516, 558–564.
55.
Fattahi, P.; Dover, J.T.; Brown, J.L. 3D Near-Field Electrospinning of Biomaterial Microfibers with Potential for Blended Microfiber-Cell-Loaded Gel Composite Structures. Adv. Healthc. Mater. 2017, 6, 1700456.
56.
Neuhäusler, A.; Rogg, K.; Schröder, S.; Spiehl, D.; Zora, H.; Arefaine, E.; Schettler, J.; Hartmann, H.; Blaeser, A. Electrospun Microfibers to Enhance Nutrient Supply in Bioinks and 3D-Bioprinted Tissue Precursors. Biofabrication 2024, 17, 015038.
57.
Ko, J.; Kan, D.; Jun, M.B.G. Combining Melt Electrospinning and Particulate Leaching for Fabrication of Porous Microfibers. Manuf. Lett. 2015, 3, 5–8.
58.
Hutmacher, D.W.; Dalton, P.D. Melt Electrospinning. Chem.—Asian J. 2011, 6, 44–56.
59.
Afghah, F.; Dikyol, C.; Altunbek, M.; Koc, B. Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing. Appl. Sci. 2019, 9, 3540.
60.
Yang, Z.; Peng, H.; Wang, W.; Liu, T. Crystallization Behavior of Poly(ε-Caprolactone)/Layered Double Hydroxide Nanocomposites. J. Appl. Polym. Sci. 2010, 116, 2658–2667.
61.
Qin, C.C.; Duan, X.P.; Wang, L.; Zhang, L.H.; Yu, M.; Dong, R.H.; Yan, X.; He, H.W.; Long, Y.Z. Melt Electrospinning of Poly(Lactic Acid) and Polycaprolactone Microfibers by Using a Hand-Operated Wimshurst Generator. Nanoscale 2015, 7, 16611–16615.
62.
Wang, C.; Xia, Q.; Yang, B.; Li, M.; Han, W.; Chen, H. Fabrication of Microfiber Bundles via Melt Electrospinning Technique. Fibers Polym. 2025, 26, 3843–3853.
63.
Wang, Y.; Tan, J.; Xu, J.; Li, H.; Yang, W. The Preparation of Polypropylene Microfiber Yarns via Vortex Airflow-Assisted Melt Differential Electrospinning. J. Appl. Polym. Sci. 2024, 141, 55382.
64.
Ko, J.; Ahsani, V.; Yao, S.X.; Mohtaram, N.K.; Lee, P.C.; Jun, M.B.G. Fabricating and Controlling PCL Electrospun Microfibers Using Filament Feeding Melt Electrospinning Technique. J. Micromech. Microeng. 2016, 27, 025007.
65.
Lee, J.K.; Ko, J.; Jun, M.B.G.; Lee, P.C. Manufacturing and Characterization of Encapsulated Microfibers with Different Molecular Weight Poly(ε-Caprolactone) (PCL) Resins Using a Melt Electrospinning Technique. Mater. Res. Express 2016, 3, 025301.
66.
Nayak, R.; Padhye, R.; Kyratzis, I.L.; Truong, Y.B.; Arnold, L. Effect of Viscosity and Electrical Conductivity on the Morphology and Fiber Diameter in Melt Electrospinning of Polypropylene. Text. Res. J. 2013, 83, 606–617.
67.
Li, Y.-M.; Wang, X.-X.; Yu, S.-X.; Zhao, Y.-T.; Yan, X.; Zheng, J.; Yu, M.; Yan, S.-Y.; Long, Y.-Z. Bubble Melt Electrospinning for Production of Polymer Microfibers. Polymers 2018, 10, 1246.
68.
O’Neill, K.L.; Dalton, P.D. A Decade of Melt Electrowriting. Small Methods 2023, 7, 2201589.
69.
Nayak, R.; Padhye, R.; Arnold, L. Melt-Electrospinning of Nanofibers; Elsevier Ltd.: Amsterdam, The Netherlands, 2017.
70.
Koenig, K.; Beukenberg, K.; Langensiepen, F.; Seide, G. A New Prototype Melt-Electrospinning Device for the Production of Biobased Thermoplastic Sub-Microfibers and Nanofibers. Biomater. Res. 2019, 23.
71.
Castilho, M.; Feyen, D.; Flandes-Iparraguirre, M.; Hochleitner, G.; Groll, J.; Doevendans, P.A.F.; Vermonden, T.; Ito, K.; Sluijter, J.P.G.; Malda, J. Melt Electrospinning Writing of Poly-Hydroxymethylglycolide-Co-ε-Caprolactone-Based Scaffolds for Cardiac Tissue Engineering. Adv. Healthc. Mater. 2017, 6, 1700311.
72.
Talebpour, P.; Mighri, F.; Ajji, A.; Heuzey, M.-C.; Virgilio, N. Tailoring the Morphology and Orientation in Immiscible Binary Polymer Blends during Melt-Electrospinning. ACS Appl. Polym. Mater. 2025, 7, 9555–9567.
73.
Koenig, K.; Hermanns, S.; Ellerkmann, J.; Saralidze, K.; Langensiepen, F.; Seide, G. The Effect of Additives and Process Parameters on the Pilot-Scale Manufacturing of Polylactic Acid Sub-Microfibers by Melt Electrospinning. Text. Res. J. 2020, 90, 1948–1961.
74.
Robinson, T.M.; Hutmacher, D.W.; Dalton, P.D.; Robinson, T.M.; Dalton, P.D.; Hutmacher, D.W. The Next Frontier in Melt Electrospinning: Taming the Jet. Adv. Funct. Mater. 2019, 29, 1904664.
75.
Bachs-Herrera, A.; Yousefzade, O.; Del Valle, L.J.; Puiggali, J. Melt Electrospinning of Polymers: Blends, Nanocomposites, Additives and Applications. Appl. Sci. 2021, 11, 1808.
76.
Zhang, L.H.; Duan, X.P.; Yan, X.; Yu, M.; Ning, X.; Zhao, Y.; Long, Y.Z. Recent Advances in Melt Electrospinning. RSC Adv. 2016, 6, 53400–53414.
77.
Yang, H.; Wang, Y.; Jang, Y.; Shani, K.; Jiao, Q.; Peters, M.; Parker, K.K.; Vlassak, J.J. Biomimetic Hierarchical Fibrous Hydrogels with High Alignment and Flaw Insensitivity. Matter 2025, 8, 102054.
78.
Golecki, H.M.I.; Yuan, H.; Glavin, C.; Potter, B.; Badrossamay, M.R.; Goss, J.A.; Phillips, M.D.; Parker, K.K. Effect of Solvent Evaporation on Fiber Morphology in Rotary Jet Spinning. Langmuir 2014, 30, 13369–13374.
79.
Badrossamay, M.R.; McIlwee, H.A.; Goss, J.A.; Parker, K.K. Nanofiber Assembly by Rotary Jet-Spinning. Nano Lett. 2010, 10, 2257–2261.
80.
Zander, N.E. Formation of Melt and Solution Spun Polycaprolactone Fibers by Centrifugal Spinning. J. Appl. Polym. Sci. 2015, 132 2.
81.
Rosa, J.C.; Bonvent, J.J.; Santos, A.R. Poly (ε-Caprolactone)/Poly (Lactic Acid) Fibers Produced by Rotary Jet Spinning for Skin Dressing with Antimicrobial Activity. J. Biomater. Appl. 2022, 36, 1641–1651.
82.
Dantas, F.L.; Rodriguez Llanos, J.H.; Pereira Rodrigues, I.C.; Pereira, K.D.; Luchessi, A.D.; Sawazaki, R.; Najar Lopes, É.S.; Gabriel, L.P. PLLA Scaffolds Functionalized with Ketoprofen via Rotary Jet Spinning for Biomedical Applications. J. Mater. Res. Technol. 2024, 30, 9020–9027.
83.
Atıcı, B.; Ünlü, C.H.; Yanilmaz, M. A Review on Centrifugally Spun Fibers and Their Applications. Polym. Rev. 2022, 62, 1–64.
84.
Mondal, B.; Arora, M.; Panwar, V.; Ghosh, D.; Mandal, D. Piezoelectret Textile Dressing for Biosignal Monitored Wound Healing. Small 2025, 21, 2503130.
85.
Zamproni, L.N.; Grinet, M.A.V.M.; Mundim, M.T.V.V.; Reis, M.B.C.; Galindo, L.T.; Marciano, F.R.; Lobo, A.O.; Porcionatto, M. Rotary Jet-Spun Porous Microfibers as Scaffolds for Stem Cells Delivery to Central Nervous System Injury. Nanomed. Nanotechnol. Biol. Med. 2019, 15, 98–107.
86.
Kwak, B.E.; Yoo, H.J.; Lee, E.; Kim, D.H. Large-Scale Centrifugal Multispinning Production of Polymer Micro- and Nanofibers for Mask Filter Application with a Potential of Cospinning Mixed Multicomponent Fibers. ACS Macro Lett. 2021, 10, 382–388.
87.
Machado-Paula, M.M.; Corat, M.A.F.; De Vasconcellos, L.M.R.; Araújo, J.C.R.; Mi, G.; Ghannadian, P.; Toniato, T.V.; Marciano, F.R.; Webster, T.J.; Lobo, A.O. Rotary Jet-Spun Polycaprolactone/Hydroxyapatite and Carbon Nanotube Scaffolds Seeded with Bone Marrow Mesenchymal Stem Cells Increase Bone Neoformation. ACS Appl. Bio Mater. 2022, 5, 1013–1024.
88.
Motta, S.E.; Peters, M.M.; Chantre, C.O.; Chang, H.; Cera, L.; Liu, Q.; Cordoves, E.M.; Fioretta, E.S.; Zaytseva, P.; Cesarovic, N.; et al. On-Demand Heart Valve Manufacturing Using Focused Rotary Jet Spinning. Matter 2023, 6, 1860–1879.
89.
MacQueen, L.A.; Alver, C.G.; Chantre, C.O.; Ahn, S.; Cera, L.; Gonzalez, G.M.; O’Connor, B.B.; Drennan, D.J.; Peters, M.M.; Motta, S.E.; et al. Muscle Tissue Engineering in Fibrous Gelatin: Implications for Meat Analogs. NPJ Sci. Food 2019, 3, 20.
90.
Ahn, S.; Chantre, C.O.; Ardoña, H.A.M.; Gonzalez, G.M.; Campbell, P.H.; Parker, K.K. Biomimetic and Estrogenic Fibers Promote Tissue Repair in Mice and Human Skin via Estrogen Receptor β. Biomaterials 2020, 255, 120149.
91.
Fu, F.; Zuo, X.; Wang, Y.; Zhao, F.; Li, C.; Zeng, Y.; Wang, L.; Wang, F. Centrifugal Spinning-Derived Biomimetic Aerogel for Rapid Hemostasis with Minimal Blood Loss. Nano Lett. 2025, 25, 6040–6050.
92.
Pereira Rodrigues, I.C.; Tamborlin, L.; Rodrigues, A.A.; Jardini, A.L.; Ducati Luchessi, A.; Maciel Filho, R.; Najar Lopes, É.S.; Pellizzer Gabriel, L. Polyurethane Fibrous Membranes Tailored by Rotary Jet Spinning for Tissue Engineering Applications. J. Appl. Polym. Sci. 2020, 137, 48455.
93.
Guner, M.B.; Dalgic, A.D.; Tezcaner, A.; Yilanci, S.; Keskin, D. A Dual-Phase Scaffold Produced by Rotary Jet Spinning and Electrospinning for Tendon Tissue Engineering. Biomed. Mater. 2020, 15, 065014.
94.
Chang, H.; Liu, Q.; Zimmerman, J.F.; Lee, K.Y.; Jin, Q.; Peters, M.M.; Rosnach, M.; Choi, S.; Kim, S.L.; Ardoña, H.A.M.; et al. Recreating the Heart’s Helical Structure-Function Relationship with Focused Rotary Jet Spinning. Science 2022, 377, 180–185.
95.
Bitay, E.; Gergely, A.L.; Kántor, J.; Szabó, Z.I. Evaluation of Lapatinib-Loaded Microfibers Prepared by Centrifugal Spinning. Polymers 2022, 14, 5557.
96.
Robert, M.; Shambaugh, L. A Macroscopic View of the Melt-Blowing Process for Producing Microfibers. Ind. Eng. Chem. Res. 2002, 27, 2363–2372.
97.
Drabek, J.; Zatloukal, M. Meltblown Technology for Production of Polymeric Microfibers/Nanofibers: A Review. Phys. Fluids 2019, 31, 091301.
98.
Hoda, N.; Mert, F.; Kara, F.; Atasagun, H.G.; Bhat, G.S. Effect of Process Parameters on Fiber Diameter and Fiber Distribution of Melt-Blown Polypropylene Microfibers Produced by Biax Line. Fibers Polym. 2021, 22, 285–293.
99.
Liu, G.; Guan, J.; Wang, X.; Yu, J.; Ding, B. Polylactic Acid (PLA) Melt-Blown Nonwovens with Superior Mechanical Properties. ACS Sustain. Chem. Eng. 2023, 11, 4279–4288.
100.
Jin, K.; Kim, S.S.; Xu, J.; Bates, F.S.; Ellison, C.J. Melt-Blown Cross-Linked Fibers from Thermally Reversible Diels–Alder Polymer Networks. ACS Macro Lett. 2018, 7, 1339–1345.
101.
Sun, G.; Han, W.; Wang, Y.; Xin, S.; Yang, J.; Zou, F.; Wang, X.; Xiao, C. Overview of the Fiber Dynamics during Melt Blowing. Ind. Eng. Chem. Res. 2022, 61, 1004–1021.
102.
Dzierzkowska, E.; Scisłowska-Czarnecka, A.; Kudzin, M.; Boguń, M.; Szatkowski, P.; Gajek, M.; Kornaus, K.; Chadzinska, M.; Stodolak-Zych, E. Effects of Process Parameters on Structure and Properties of Melt-Blown Poly(Lactic Acid) Nonwovens for Skin Regeneration. J. Funct. Biomater. 2021, 12, 16.
103.
Wang, R.; Zhang, H.; Cao, Y.; Zhai, Q.; Hu, J.; Zhen, Q.; Qian, X. Preparation of PLA/PEG@SDS Microfibers-Based Nonwovens via Melt-Blown Process Parameters: Wound Dressings with Enhanced Water Wetting Performance. J. Appl. Polym. Sci. 2023, 140, 54234.
104.
Brochocka, A.; Nowak, A.; Majchrzycka, K.; Puchalski, M.; Sztajnowski, S. Multifunctional Polymer Composites Produced by Melt-Blown Technique to Use in Filtering Respiratory Protective Devices. Materials 2020, 13, 712.
105.
González-Sánchez, A.; Rosas-Macías, R.; Hernández-Bautista, J.E.; Valdez-Garza, J.A.; Rodríguez-Fuentes, N.; Soriano-Corral, F.; Ledezma-Pérez, A.S.; Ávila-Orta, C.A.; Cruz-Delgado, V.J. Antimicrobial Properties of Polyester/Copper Nanocomposites by Melt-Spinning and Melt-Blowing Techniques. Textiles 2024, 4, 1–16.
106.
Kang, Y.O.; Im, J.N.; Park, W.H. Morphological and Permeable Properties of Antibacterial Double-Layered Composite Nonwovens Consisting of Microfibers and Nanofibers. Compos. Part B: Eng. 2015, 75, 256–263.
107.
Volpi, M.; Paradiso, A.; Walejewska, E.; Gargioli, C.; Costantini, M.; Swieszkowski, W. Automated Microfluidics-Assisted Hydrogel-Based Wet-Spinning for the Biofabrication of Biomimetic Engineered Myotendinous Junction. Adv. Healthc. Mater. 2024, 13, 2402075.
108.
Lavin, D.M.; Stefani, R.M.; Zhang, L.; Furtado, S.; Hopkins, R.A.; Mathiowitz, E. Multifunctional Polymeric Microfibers with Prolonged Drug Delivery and Structural Support Capabilities. Acta Biomater. 2012, 8, 1891–1900.
109.
Wang, C.; Li, Y.; Yu, H.Y.; Abdalkarim, S.Y.H.; Zhou, J.; Yao, J.; Zhang, L. Continuous Meter-Scale Wet-Spinning of Cornlike Composite Fibers for Eco-Friendly Multifunctional Electronics. ACS Appl. Mater. Interfaces 2021, 13, 40953–40963.
110.
Paradiso, A.; Volpi, M.; Martinez, D.C.; Jaroszewicz, J.; Costantini, M.; Swieszkowski, W. Engineering Biomimetic Microvascular Capillary Networks in Hydrogel Fibrous Scaffolds via Microfluidics-Assisted Co-Axial Wet-Spinning. ACS Appl. Mater. Interfaces 2024, 16, 65927–65941.
111.
Lüken, A.; Geiger, M.; Steinbeck, L.; Joel, A.-C.; Lampert, A.; Linkhorst, J.; Wessling, M.; Lüken, A.; Geiger, M.; Steinbeck, L.; et al. Biocompatible Micron-Scale Silk Fibers Fabricated by Microfluidic Wet Spinning. Adv. Healthc. Mater. 2021, 10, 2100898.
112.
Lee, B.R.; Lee, K.H.; Kang, E.; Kim, D.S.; Lee, S.H. Microfluidic Wet Spinning of Chitosan-Alginate Microfibers and Encapsulation of HepG2 Cells in Fibers. Biomicrofluidics 2011, 5, 022208.
113.
Xu, B.; Du, L.; Zhang, J.; Zhu, M.; Ji, S.; Zhang, Y.; Kong, D.; Ma, X.; Yang, Q.; Wang, L. Circumferentially Oriented Microfiber Scaffold Prepared by Wet-Spinning for Tissue Engineering of Annulus Fibrosus. RSC Adv. 2015, 5, 42705–42713.
114.
Li, Y.; Hu, H.; Salim, T.; Cheng, G.; Lam, Y.M.; Ding, J. Flexible Wet-Spun PEDOT:PSS Microfibers Integrating Thermal-Sensing and Joule Heating Functions for Smart Textiles. Polymers 2023, 15, 3432.
115.
Zeng, H.; Gao, C.; Yu, Y.; Jiang, M.; Deng, T.; Zhu, J. Wet Spinning Enabled Advanced PEDOT:PSS Composite Fibers for Smart Devices. Accounts Mater. Res. 2025, 6, 952–963.
116.
Lavin, D.M.; Zhang, L.; Furtado, S.; Hopkins, R.A.; Mathiowitz, E. Effects of Protein Molecular Weight on the Intrinsic Material Properties and Release Kinetics of Wet Spun Polymeric Microfiber Delivery Systems. Acta Biomater. 2013, 9, 4569–4578.
117.
Han, L.H.; Yu, S.; Wang, T.; Behn, A.W.; Yang, F. Microribbon-Like Elastomers for Fabricating Macroporous and Highly Flexible Scaffolds That Support Cell Proliferation in 3D. Adv. Funct. Mater. 2013, 23, 346–358.
118.
Wang, L.; Zhang, J.; Wang, L.; Zhu, M.; Xiao, N.; Kong, D. Wet-Spun Poly(ε-Caprolactone) Microfiber Scaffolds for Oriented Growth and Infiltration of Smooth Muscle Cells. Mater. Lett. 2014, 132, 59–62.
119.
Zheng, T.; Pour Shahid Saeed Abadi, P.; Seo, J.; Cha, B.H.; Miccoli, B.; Li, Y.C.; Park, K.; Park, S.; Choi, S.J.; Bayaniahangar, R.; et al. Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications. ACS Appl. Mater. Interfaces 2019, 11, 20615–20627.
120.
Puppi, D.; Braccini, S.; Battisti, A.; Manariti, A.; Pecorini, G.; Samal, S.K. Additive Manufacturing of Wet-Spun Polysulfone Medical Implants. ACS Biomater. Sci. Eng. 2023, 9, 5418–5429.
121.
Yang, Y.; Sun, J.; Liu, X.; Guo, Z.; He, Y.; Wei, D.; Zhong, M.; Guo, L.; Fan, H.; Zhang, X. Wet-Spinning Fabrication of Shear-Patterned Alginate Hydrogel Microfibers and the Guidance of Cell Alignment. Regen. Biomater. 2017, 4, 299–307.
122.
Gong, R.; Dong, Y.; Ge, D.; Miao, Z.; Yu, H.Y. Wet Spinning Fabrication of Robust and Uniform Intrinsically Conductive Cellulose Nanofibril/Silk Conductive Fibers as Bifunctional Strain/Humidity Sensor in Potential Smart Dressing. Adv. Fiber Mater. 2024, 6, 993–1007.
123.
Su, R.; Ai, Y.; Wang, J.; Wu, L.; Sun, H.; Ding, M.; Xie, R.; Liang, Q. Engineered Microfibers for Tissue Engineering. ACS Appl. Bio Mater. 2024.
124.
Ren, N.; Qiao, A.; Cui, M.; Huang, R.; Qi, W.; Su, R. Design and Fabrication of Nanocellulose-Based Microfibers by Wet Spinning. Chem. Eng. Sci. 2023, 282, 119320.
125.
Pullagura, B.K.; Gundabala, V. Microfluidics-Based On-Demand Generation of Nonwoven and Single Polymer Microfibers. Langmuir 2020, 36, 1227–1234.
126.
Abrishamkar, A.; Nilghaz, A.; Saadatmand, M.; Naeimirad, M.; Demello, A.J. Microfluidic-Assisted Fiber Production: Potentials, Limitations, and Prospects. Biomicrofluidics 2022, 16, 61504.
127.
Hwang, C.M.; Khademhosseini, A.; Park, Y.; Sun, K.; Lee, S.H. Microfluidic Chip-Based Fabrication of PLGA Microfiber Scaffolds for Tissue Engineering. Langmuir 2008, 24, 6845–6851.
128.
Guo, J.; Yu, Y.; Wang, H.; Zhang, H.; Zhang, X.; Zhao, Y. Conductive Polymer Hydrogel Microfibers from Multiflow Microfluidics. Small 2019, 15, 1805162.
129.
Zhao, M.; Liu, H.; Zhang, X.; Wang, H.; Tao, T.; Qin, J. A Flexible Microfluidic Strategy to Generate Grooved Microfibers for Guiding Cell Alignment. Biomater. Sci. 2021, 9, 4880–4890.
130.
Lee, D.; Yang, K.; Xie, J. Innovative Microfluidic Technologies in Precision Research and Therapy Development in Diabetic Neuropathy: A Narrative Review. Adv. Technol. Neurosci. 2024, 1, 123–137.
131.
Liu, W.; Xu, Z.; Sun, L.; Guo, P.; Zeng, C.; Wang, C.; Zhang, L. Polymerization-Induced Phase Separation Fabrication: A Versatile Microfluidic Technique to Prepare Microfibers with Various Cross Sectional Shapes and Structures. Chem. Eng. J. 2017, 315, 25–34.
132.
Lu, L.; Fan, S.; Niu, Q.; Peng, Q.; Geng, L.; Yang, G.; Shao, H.; Hsiao, B.S.; Zhang, Y. Strong Silk Fibers Containing Cellulose Nanofibers Generated by a Bioinspired Microfluidic Chip. ACS Sustain. Chem. Eng. 2019, 7, 14765–14774.
133.
Zhao, Z.; Wang, J.; Yuan, H.; Xu, J.; Gao, H.; Nie, Y. Preparation of Antibacterial Biobased Fibers by Triaxial Microfluidic Spinning Technology Using Ionic Liquids as the Solvents. ACS Appl. Mater. Interfaces 2024, 16, 18063–18074.
134.
Chen, N.; Wei, W.; Ning, N.; Wu, H.; Tian, M. All-Polymeric Stretchable Conductive Fiber with Versatile Intelligent Wearable Applications via Microfluidic Spinning Technology. Chem. Eng. J. 2024, 487, 150741.
135.
Geiger, M.; Frank, J.; Schmitz, F.; Paul, R.; Rauer, S.B.; Koulchitsky, S.; Lampert, A.; Linkhorst, J.; Wessling, M. Microfluidic Spinning of PEDOT:PSS Microfibers for Nerve Guidance Conduits. Adv. Mater. Technol. 2025, 2401996.
136.
Shang, L.; Fu, F.; Cheng, Y.; Yu, Y.; Wang, J.; Gu, Z.; Zhao, Y. Bioinspired Multifunctional Spindle-Knotted Microfibers from Microfluidics. Small 2017, 13, 1600286.
137.
Peng, Y.; Shang, Y.; Che, J.; Yu, Y.; Zhao, Y.; Gu, X. Multifunctional Analgesic Sutures from Microfluidic Spinning Technology. Adv. Healthc. Mater. 2025, 14, 2402420.
138.
Masuda, A.; Kurashina, Y.; Tani, H.; Soma, Y.; Muramatsu, J.; Itai, S.; Tohyama, S.; Onoe, H. Maturation of Human IPSC-Derived Cardiac Microfiber with Electrical Stimulation Device. Adv. Healthc. Mater. 2024, 13, 2303477.
139.
Liu, J.D.; Du, X.Y.; Chen, S. A Phase Inversion-Based Microfluidic Fabrication of Helical Microfibers towards Versatile Artificial Abdominal Skin. Angew. Chem. Int. Ed. 2021, 60, 25089–25096.
140.
Magnani, J.S.; Montazami, R.; Hashemi, N.N. Recent Advances in Microfluidically Spun Microfibers for Tissue Engineering and Drug Delivery Applications. Annu. Rev. Anal. Chem. 2021, 14, 185–205.
141.
Jun, Y.; Kang, E.; Chae, S.; Lee, S.H. Microfluidic Spinning of Micro- and Nano-Scale Fibers for Tissue Engineering. Lab. Chip 2014, 14, 2145–2160.
142.
Cheng, Y.; Yu, Y.; Fu, F.; Wang, J.; Shang, L.; Gu, Z.; Zhao, Y. Controlled Fabrication of Bioactive Microfibers for Creating Tissue Constructs Using Microfluidic Techniques. ACS Appl. Mater. Interfaces 2016, 8, 1080–1086.
143.
Huang, Q.; He, F.; Yu, J.; Zhang, J.; Du, X.; Li, Q.; Wang, G.; Yu, Z.; Chen, S. Microfluidic Spinning-Induced Heterotypic Bead-on-String Fibers for Dual-Cargo Release and Wound Healing. J. Mater. Chem. B 2021, 9, 2727–2735.
144.
Lin, H.H.; Chao, P.H.G.; Tai, W.C.; Chang, P.C. 3d-Printed Collagen-Based Waveform Microfibrous Scaffold for Periodontal Ligament Reconstruction. Int. J. Mol. Sci. 2021, 22, 7725.
145.
Bojedla, S.S.R.; Kattimani, V.; Alwala, A.M.; Nikzad, M.; Masood, S.H.; Riza, S.; Pati, F. Augmented Repair and Regeneration of Critical Size Rabbit Calvaria Defects with 3D Printed Silk Fibroin Microfibers Reinforced PCL Composite Scaffolds. Biomed. Mater. Devices 2023, 1, 942–955.
146.
Luo, Z.; Lian, L.; Stocco, T.; Guo, J.; Mei, X.; Cai, L.; Andrabi, S.M.; Su, Y.; Tang, G.; Ravanbakhsh, H.; et al. 3D Assembly of Cryo(Bio)Printed Modular Units for Shelf-Ready Scalable Tissue Fabrication. Adv. Funct. Mater. 2024, 34, 2309173.
147.
Jiang, X.; Kong, Y.; Kuss, M.; Weisenburger, J.; Haider, H.; Harms, R.; Shi, W.; Liu, B.; Xue, W.; Dong, J.; et al. 3D Bioprinting of Multilayered Scaffolds with Spatially Differentiated ADMSCs for Rotator Cuff Tendon-to-Bone Interface Regeneration. Appl. Mater. Today 2022, 27, 101510.
148.
Heinrich, M.A.; Liu, W.; Jimenez, A.; Yang, J.; Akpek, A.; Liu, X.; Pi, Q.; Mu, X.; Hu, N.; Schiffelers, R.M.; et al. 3D Bioprinting: From Benches to Translational Applications. Small 2019, 15, 1805510.
149.
Lee, D.; Tran, H.Q.; Sharma, N.S.; Andrabi, S.M.; Yan, Z.; Killeen, A.C.; Reinhardt, R.A.; Zhu, W.; Xie, J. 3D-Printed Microfluidic Platform for Creating Porous Nanofibrous Microspheres to Regulate Cell Response and Enhance Tissue Regeneration. Small 2025, 2502033.
150.
Prendergast, M.E.; Burdick, J.A. Recent Advances in Enabling Technologies in 3D Printing for Precision Medicine. Adv. Mater. 2020, 32, 1902516.
151.
Jiang, Z.; Diggle, B.; Tan, M.L.; Viktorova, J.; Bennett, C.W.; Connal, L.A. Extrusion 3D Printing of Polymeric Materials with Advanced Properties. Adv. Sci. 2020, 7, 2001379.
152.
Zhou, L.Y.; Fu, J.; He, Y. A Review of 3D Printing Technologies for Soft Polymer Materials. Adv. Funct. Mater. 2020, 30, 2000187.
153.
Zhou, X.; Yu, X.; You, T.; Zhao, B.; Dong, L.; Huang, C.; Zhou, X.; Xing, M.; Qian, W.; Luo, G.; et al. 3D Printing-Based Hydrogel Dressings for Wound Healing. Adv. Sci. 2024, 11, 2404580.
154.
Yu, C.; Zhu, W.; Sun, B.; Mei, D.; Gou, M.; Chen, S. Modulating Physical, Chemical, and Biological Properties in 3D Printing for Tissue Engineering Applications. Appl. Phys. Rev. 2018, 5, 41107.
155.
Diloksumpan, P.; De Ruijter, M.; Castilho, M.; Gbureck, U.; Vermonden, T.; Van Weeren, P.R.; Malda, J.; Levato, R. Combining Multi-Scale 3D Printing Technologies to Engineer Reinforced Hydrogel-Ceramic Interfaces. Biofabrication 2020, 12, 025014.
156.
Cedillo-Servin, G.; Dahri, O.; Meneses, J.; van Duijn, J.; Moon, H.; Sage, F.; Silva, J.; Pereira, A.; Magalhães, F.D.; Malda, J.; et al. 3D Printed Magneto-Active Microfiber Scaffolds for Remote Stimulation and Guided Organization of 3D In Vitro Skeletal Muscle Models. Small 2024, 20, 2307178.
157.
Ainsworth, M.J.; Lotz, O.; Gilmour, A.; Zhang, A.; Chen, M.J.; McKenzie, D.R.; Bilek, M.M.M.; Malda, J.; Akhavan, B.; Castilho, M. Covalent Protein Immobilization on 3D-Printed Microfiber Meshes for Guided Cartilage Regeneration. Adv. Funct. Mater. 2023, 33, 2206583.
158.
Shen, Y.; Pan, Y.; Liang, F.; Song, J.; Yu, X.; Cui, J.; Cai, G.; El-Newehy, M.; Abdulhameed, M.M.; Gu, H.; et al. Development of 3D Printed Electrospun Vascular Graft Loaded with Tetramethylpyrazine for Reducing Thrombosis and Restraining Aneurysmal Dilatation. Burn. Trauma. 2024, 12, 8.
159.
Iturriaga, L.; Van Gordon, K.D.; Larrañaga-Jaurrieta, G.; Camarero-Espinosa, S. Strategies to Introduce Topographical and Structural Cues in 3D-Printed Scaffolds and Implications in Tissue Regeneration. Adv. NanoBiomed Res. 2021, 1, 2100068.
160.
Deng, X.; Qi, C.; Meng, S.; Dong, H.; Wang, T.; Liu, Z.; Kong, T. All-Aqueous Embedded 3D Printing for Freeform Fabrication of Biomimetic 3D Constructs. Adv. Mater. 2024, 36, 2406825.
161.
Wang, C.; Shahriar, S.M.S.; Su, Y.; Hayati, F.; Andrabi, S.M.; Xiao, Y.; Busquets, M.E.; Sharma, N.S.; Xie, J. Three-Dimensional Bioprinting of Biphasic Nanobioink for Enhanced Diabetic Wound Healing. ACS Nano 2025, 19, 21411–21425.
162.
von Witzleben, M.; Stoppe, T.; Ahlfeld, T.; Bernhardt, A.; Polk, M.L.; Bornitz, M.; Neudert, M.; Gelinsky, M. Biomimetic Tympanic Membrane Replacement Made by Melt Electrowriting. Adv. Healthc. Mater. 2021, 10, 2002089.
163.
Hrynevich, A.; Elçi, B.; Haigh, J.N.; McMaster, R.; Youssef, A.; Blum, C.; Blunk, T.; Hochleitner, G.; Groll, J.; Dalton, P.D. Dimension-Based Design of Melt Electrowritten Scaffolds. Small 2018, 14, 1800232.
164.
Mueller, K.M.A.; Hangleiter, A.; Burkhardt, S.; Rojas-González, D.M.; Kwade, C.; Pammer, S.T.; Leonhardt, S.; Mela, P. Filament-Based Melt Electrowriting Enables Dual-Mode Additive Manufacturing for Multiscale Constructs. Small Sci. 2023, 3, 2300021.
165.
Mondadori, C.; Chandrakar, A.; Lopa, S.; Wieringa, P.; Talò, G.; Perego, S.; Lombardi, G.; Colombini, A.; Moretti, M.; Moroni, L. Assessing the Response of Human Primary Macrophages to Defined Fibrous Architectures Fabricated by Melt Electrowriting. Bioact. Mater. 2023, 21, 209–222.
166.
Florczak, S.; Lorson, T.; Zheng, T.; Mrlik, M.; Hutmacher, D.W.; Higgins, M.J.; Luxenhofer, R.; Dalton, P.D. Melt Electrowriting of Electroactive Poly(Vinylidene Difluoride) Fibers. Polym. Int. 2019, 68, 735–745.
167.
Mueller, K.M.A.; Unterrainer, A.; Rojas-González, D.M.; De-Juan-Pardo, E.; Willner, M.S.; Herzen, J.; Mela, P. Introducing Controlled Microporosity in Melt Electrowriting. Adv. Mater. Technol. 2023, 8, 2201158.
168.
Sarfraz, M.H.; Chen, Y.; Xie, M.; He, Y. 3D Printing of High-Resolution Multi-Layer Scaffolds With Melt Electrowriting. Adv. Mater. Technol. 2025, 2402029.
169.
Pang, L.; Paxton, N.C.; Ren, J.; Liu, F.; Zhan, H.; Woodruff, M.A.; Bo, A.; Gu, Y. Development of Mechanically Enhanced Polycaprolactone Composites by a Functionalized Titanate Nanofiller for Melt Electrowriting in 3D Printing. ACS Appl. Mater. Interfaces 2020, 12, 47993–48006.
170.
Saidy, N.T.; Wolf, F.; Bas, O.; Keijdener, H.; Hutmacher, D.W.; Mela, P.; De-Juan-Pardo, E.M. Biologically Inspired Scaffolds for Heart Valve Tissue Engineering via Melt Electrowriting. Small 2019, 15, 1900873.
171.
Saiz, P.G.; Reizabal, A.; Vilas-Vilela, J.L.; Dalton, P.D.; Lanceros-Mendez, S. Materials and Strategies to Enhance Melt Electrowriting Potential. Adv. Mater. 2024, 36, 2312084.
172.
Snow, F.; Doyle, S.E.; Liu, E.; Rauch, D.De; Millett, D.; Wilding-Mcbride, J.; Kita, M.; Pirogova, E.; Kapsa, R.M.I.; Quigley, A. A Detailed Guide to Melt Electro-Writing for Tissue Engineering Applications. Biofabrication 2025, 17, 042004.
173.
Castilho, M.; van Mil, A.; Maher, M.; Metz, C.H.G.; Hochleitner, G.; Groll, J.; Doevendans, P.A.; Ito, K.; Sluijter, J.P.G.; Malda, J. Melt Electrowriting Allows Tailored Microstructural and Mechanical Design of Scaffolds to Advance Functional Human Myocardial Tissue Formation. Adv. Funct. Mater. 2018, 28, 1803151.
174.
Kim, J.; Bakirci, E.; O’Neill, K.L.; Hrynevich, A.; Dalton, P.D. Fiber Bridging during Melt Electrowriting of Poly(ε-Caprolactone) and the Influence of Fiber Diameter and Wall Height. Macromol. Mater. Eng. 2021, 306, 2000685.
175.
Kong, X.; Zhu, D.; Hu, Y.; Liu, C.; Zhang, Y.; Wu, Y.; Tan, J.; Luo, Y.; Chen, J.; Xu, T.; et al. Melt Electrowriting (MEW)-PCL Composite Three-Dimensional Exosome Hydrogel Scaffold for Wound Healing. Mater. Des. 2024, 238, 112717.
176.
Luxenhofer, R.; Keßler, L.; Mirzaei, Z.; Kade, J.C. Highly Porous and Drug-Loaded Amorphous Solid Dispersion Microfiber Scaffolds of Indomethacin Prepared by Melt Electrowriting. ACS Appl. Polym. Mater. 2023, 5, 913–922.
177.
Kilian, D.; Witzleben, M.von; Lanaro, M.; Wong, C.S.; Vater, C.; Lode, A.; Allenby, M.C.; Woodruff, M.A.; Gelinsky, M. 3D Plotting of Calcium Phosphate Cement and Melt Electrowriting of Polycaprolactone Microfibers in One Scaffold: A Hybrid Additive Manufacturing Process. J. Funct. Biomater. 2022, 13, 75.
178.
Loewner, S.; Heene, S.; Baroth, T.; Heymann, H.; Cholewa, F.; Blume, H.; Blume, C. Recent Advances in Melt Electro Writing for Tissue Engineering for 3D Printing of Microporous Scaffolds for Tissue Engineering. Front. Bioeng. Biotechnol. 2022, 10, 896719.
179.
Mueller, K.M.A.; Ahrens, C.; Grefen, L.; Mansi, S.; Arcuti, D.; De-Juan-Pardo, E.; Kur, F.; Hagl, C.; Mela, P. Programmable Compliance in Small-Diameter Vascular Grafts by Design of Melt-Electrowritten Scaffold Architectures for In Situ Tissue Engineering. Adv. Healthc. Mater. 2025, 02038.
180.
Lai, X.; Huang, J.; Huang, S.; Wang, J.; Zheng, Y.; Luo, Y.; Tang, L.; Gao, B.; Tang, Y. Antibacterial and Osteogenic Dual-Functional Micronano Composite Scaffold Fabricated via Melt Electrowriting and Solution Electrospinning for Bone Tissue Engineering. ACS Appl. Mater. Interfaces 2024, 16, 37707–37721.
181.
Janssen, R.; Schulze, H.S.; Nelissen, C.M.L.; Valverde, M.G.; Hrynevich, A.; Jong, G.A.H.; Genderen, A.M.; Malda, J.; Bastiaan-Net, S.; Willemsen, L.E.M.; et al. Half-Pipe Melt Electrowritten Scaffolds Support Engineering of an Immunocompetent Hydrogel-Embedded Intestine-on-a-Chip. Adv. Sci. 2025, 07132.
182.
Shahverdi, M.; Seifi, S.; Akbari, A.; Mohammadi, K.; Shamloo, A.; Movahhedy, M.R. Melt Electrowriting of PLA, PCL, and Composite PLA/PCL Scaffolds for Tissue Engineering Application. Sci. Rep. 2022, 12, 19935.
183.
Ranat, K.; Phan, H.; Ellythy, S.; Kenter, M.; Akkouch, A. Advancements in Musculoskeletal Tissue Engineering: The Role of Melt Electrowriting in 3D-Printed Scaffold Fabrication. J. Funct. Biomater. 2025, 16, 163.
184.
Ross, M.T.; Kilian, D.; Lode, A.; Ren, J.; Allenby, M.C.; Gelinsky, M.; Woodruff, M.A. Using Melt-Electrowritten Microfibres for Tailoring Scaffold Mechanics of 3D Bioprinted Chondrocyte-Laden Constructs. Bioprinting 2021, 23, 00158.
185.
Sun, T.; Lu, H.; Luposchainsky, S.; Yang, L.; Zhang, X.; Hirano, A.; Nakano, Y.; Shinichi, Y.; Xu, H. Challenges of High-Temperature Melt Electrowriting: A Study of EVOH Printing. Polymer 2025, 331, 128518.
186.
Chandrakar, A.; van der Spoel, M.; Beeren, I.; Giacomini, F.; Mondadori, C.; Eischen-Loges, M.J.; Truckenmüller, R.; Moroni, L.; Wieringa, P. Melt Electrowriting of Hydrophilic/Hydrophobic Multiblock Copolymers for Bone Tissue Regeneration. Biomater. Adv. 2025, 169, 214167.
187.
Ni, Z.; Zhu, Z.; Ji, Y.; He, X.; Fu, X.; Yang, W.; Wang, Y. Biomimetic Microadhesion Guided Instant Spinning. Nano Lett. 2022, 22, 9396–9404.
188.
Liu, Y.; Wang, C.; Liu, Z.; Qu, X.; Gai, Y.; Xue, J.; Chao, S.; Huang, J.; Wu, Y.; Li, Y.; et al. Self-Encapsulated Ionic Fibers Based on Stress-Induced Adaptive Phase Transition for Non-Contact Depth-of-Field Camouflage Sensing. Nat. Commun. 2024, 15, 663.
189.
Zhao, Y.; Gumyusenge, A.; He, J.; Qu, G.; McNutt, W.W.; Long, Y.; Zhang, H.; Huang, L.; Diao, Y.; Mei, J.; et al. Continuous Melt-Drawing of Highly Aligned Flexible and Stretchable Semiconducting Microfibers for Organic Electronics. Adv. Funct. Mater. 2018, 28, 1705584.
190.
Zhang, T.; Yin, L.; Hui, Z.; Zhang, R.; Fu, J.; Xu, H.; Zhou, J.; Hou, W.; Yao, Y.; An, J.; et al. Biomimetic Spinning of Glassy Ionogel Fibers with Tailorable Mechanical Properties for Versatile Applications. Chem. Eng. J. 2025, 524, 169443.
191.
Xue, J.; Wu, T.; Dai, Y.; Xia, Y. Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications. Chem. Rev. 2019, 119, 5298–5415.
192.
Yu, Y.; Fu, F.; Shang, L.; Cheng, Y.; Gu, Z.; Zhao, Y. Bioinspired Helical Microfibers from Microfluidics. Adv. Mater. 2017, 29, 1605765.
193.
Lan, D.; Shang, Y.; Su, H.; Liang, M.; Liu, Y.; Li, H.; Feng, Q.; Cao, X.; Dong, H. Facile Fabrication of Hollow Hydrogel Microfiber via 3D Printing-Assisted Microfluidics and Its Application as a Biomimetic Blood Capillary. ACS Biomater. Sci. Eng. 2021, 7, 4971–4981.
194.
Chen, Y.; Deng, Z.; Ouyang, R.; Zheng, R.; Jiang, Z.; Bai, H.; Xue, H. 3D Printed Stretchable Smart Fibers and Textiles for Self-Powered e-Skin. Nano Energy 2021, 84, 105866.
195.
Tibbitt, M.W.; Rodell, C.B.; Burdick, J.A.; Anseth, K.S. Progress in Material Design for Biomedical Applications. Proc. Natl. Acad. Sci. 2015, 112, 14444–14451.
196.
Guo, B.; Glavas, L.; Albertsson, A.C. Biodegradable and Electrically Conducting Polymers for Biomedical Applications. Prog. Polym. Sci. 2013, 38, 1263–1286.
197.
Du, X.Y.; Li, Q.; Wu, G.; Chen, S. Multifunctional Micro/Nanoscale Fibers Based on Microfluidic Spinning Technology. Adv. Mater. 2019, 31, 1903733.
198.
Song, R.; Murphy, M.; Li, C.; Ting, K.; Soo, C.; Zheng, Z. Current Development of Biodegradable Polymeric Materials for Biomedical Applications. Drug Des. Devel. Ther. 2018, 12, 3117–3145.
199.
Shahriar, S.M.S.; McCarthy, A.D.; Andrabi, S.M.; Su, Y.; Polavoram, N.S.; John, J.V.; Matis, M.P.; Zhu, W.; Xie, J. Mechanically Resilient Hybrid Aerogels Containing Fibers of Dual-Scale Sizes and Knotty Networks for Tissue Regeneration. Nat. Commun. 2024, 15, 1080.
200.
Yu, Y.; Jin, B.; Chen, J.; Lou, C.; Guo, J.; Yang, C.; Zhao, Y. Nerve-on-a-Chip Derived Biomimicking Microfibers for Peripheral Nerve Regeneration. Adv. Sci. 2023, 10, 2207536.
201.
Mondal, B.; Mandal, D. Geometry-Modulated All Organic 3D Printed Smart PLA Fibers for Flextension Amplified Giant Mechanical Energy Harvesting and Machine Learning Assisted Pressure Mapping. Chem. Eng. J. 2024, 496, 154281.
202.
Shao, L.; Gao, Q.; Xie, C.; Fu, J.; Xiang, M.; He, Y. Bioprinting of Cell-Laden Microfiber: Can It Become a Standard Product? Adv. Healthc. Mater. 2019, 8, 1900014.
203.
Dias, Y.J.; Robles, J.R.; Sinha-Ray, S.; Abiade, J.; Pourdeyhimi, B.; Niemczyk-Soczynska, B.; Kolbuk, D.; Sajkiewicz, P.; Yarin, A.L. Solution-Blown Poly(Hydroxybutyrate) and ε-Poly-l-Lysine Submicro- and Microfiber-Based Sustainable Nonwovens with Antimicrobial Activity for Single-Use Applications. ACS Biomater. Sci. Eng. 2021, 7, 3980–3992.
204.
Yuan, S.; Li, Z.; Song, L.; Shi, H.; Luan, S.; Yin, J. Liquid-Infused Poly(Styrene-b-Isobutylene-b-Styrene) Microfiber Coating Prevents Bacterial Attachment and Thrombosis. ACS Appl. Mater. Interfaces 2016, 8, 21214–21220.
205.
Miele, D.; Nomicisio, C.; Musitelli, G.; Boselli, C.; Icaro Cornaglia, A.; Sànchez-Espejo, R.; Vigani, B.; Viseras, C.; Rossi, S.; Sandri, G. Design and Development of Polydioxanone Scaffolds for Skin Tissue Engineering Manufactured via Green Process. Int. J. Pharm. 2023, 634, 122669.
206.
Jia, Z.; Gong, J.; Zeng, Y.; Ran, J.; Liu, J.; Wang, K.; Xie, C.; Lu, X.; Wang, J. Bioinspired Conductive Silk Microfiber Integrated Bioelectronic for Diagnosis and Wound Healing in Diabetes. Adv. Funct. Mater. 2021, 31, 2010461.
207.
Guo, J.; Yu, Y.; Zhang, H.; Sun, L.; Zhao, Y. Elastic MXene Hydrogel Microfiber-Derived Electronic Skin for Joint Monitoring. ACS Appl. Mater. Interfaces 2021, 13, 47800–47806.
208.
Yang, X.; Cai, H.; Li, R.; He, Z.; Liu, Y.; Wu, J.; Xu, Z.; Yang, L.; Zhu, Z.; Wang, J.; et al. Macro- or Microfiber Scaffolds with Different Fiber Arrangements: Determining the Best Design for Osteogenesis. Ind. Eng. Chem. Res. 2024, 63, 7540–7555.
209.
Tian, Y.; Wang, J.; Wang, L. Microfluidic Fabrication of Bioinspired Cavity-Microfibers for 3D Scaffolds. ACS Appl. Mater. Interfaces 2018, 10, 29219–29226.
210.
Han, W.; Wang, L.; Li, Q.; Ma, B.; He, C.; Guo, X.; Nie, J.; Ma, G. A Review: Current Status and Emerging Developments on Natural Polymer-Based Electrospun Fibers. Macromol. Rapid Commun. 2022, 43, 2200456.
211.
Satchanska, G.; Davidova, S.; Petrov, P.D. Natural and Synthetic Polymers for Biomedical and Environmental Applications. Polymers 2024, 16, 1159.
212.
Wei, S.; Hu, Q.; Dong, J.; Sun, Y.; Bai, J.; Shan, H.; Gao, X.; Sheng, L.; Dai, J.; Jiang, F.; et al. Mechanically Enhanced Biodegradable Scaffold Based on SF Microfibers for Repairing Bone Defects in the Distal Femur of Rats. Int. J. Biol. Macromol. 2024, 282, 137372.
213.
Moghimi, N.; Kamaraj, M.; Zehtabi, F.; Amin Yavari, S.; Kohandel, M.; Khademhosseini, A.; John, J.V. Development of Bioactive Short Fiber-Reinforced Printable Hydrogels with Tunable Mechanical and Osteogenic Properties for Bone Repair. J. Mater. Chem. B 2024, 12, 2818–2830.
214.
Tian, H.; Tang, Z.; Zhuang, X.; Chen, X.; Jing, X. Biodegradable Synthetic Polymers: Preparation, Functionalization and Biomedical Application. Prog. Polym. Sci. 2012, 37, 237–280.
215.
Ye, C.; Zhao, J.; Zheng, Y.; Wu, C.; Chen, Y.; Wu, H.; An, X.; Huang, M.; Wang, S. Preparation of Poly(Lactic-Co-Glycolic Acid)-Based Composite Microfibers for Postoperative Treatment of Tumor in NIR I and NIR II Biowindows. Macromol. Biosci. 2018, 18, 1800206.
216.
Jung, J.H.; Choi, C.H.; Chung, S.; Chung, Y.M.; Lee, C.S. Microfluidic Synthesis of a Cell Adhesive Janus Polyurethane Microfiber. Lab. Chip 2009, 9, 2596–2602.
217.
Ranjan, V.D.; Zeng, P.; Li, B.; Zhang, Y. In Vitro Cell Culture in Hollow Microfibers with Porous Structures. Biomater. Sci. 2020, 8, 2175–2188.
218.
Dores, R.; Oliveira, M.S.N.; Bimbo, L.M. Microfluidic Manufacture of Composite Fibers for Biomedical Applications. Adv. Mater. Technol. 2025, 10, 2400976.
219.
Ramakrishna, S.; Mayer, J.; Wintermantel, E.; Leong, K.W. Biomedical Applications of Polymer-Composite Materials: A Review. Compos. Sci. Technol. 2001, 61, 1189–1224.
220.
De las Heras Alarcón, C.; Pennadam, S.; Alexander, C. Stimuli Responsive Polymers for Biomedical Applications. Chem. Soc. Rev. 2005, 34, 276–285.
221.
Delaey, J.; Dubruel, P.; Van Vlierberghe, S. Shape-Memory Polymers for Biomedical Applications. Adv. Funct. Mater. 2020, 30, 1909047.
222.
Buratti, E.; Sanzari, I.; Dinelli, F.; Prodromakis, T.; Bertoldo, M. Formation and Stability of Smooth Thin Films with Soft Microgels Made of Poly(N-Isopropylacrylamide) and Poly(Acrylic Acid). Polymers 2020, 12, 2638.
223.
Wu, R.; Kim, T. Review of Microfluidic Approaches for Fabricating Intelligent Fiber Devices: Importance of Shape Characteristics. Lab. Chip 2021, 21, 1217–1240.
224.
Chen, C.; Chen, X.; Zhang, H.; Zhang, Q.; Wang, L.; Li, C.; Dai, B.; Yang, J.; Liu, J.; Sun, D. Electrically-Responsive Core-Shell Hybrid Microfibers for Controlled Drug Release and Cell Culture. Acta Biomater. 2017, 55, 434–442.
225.
Zou, W.; Yan, Y.; Fang, J.; Yang, Y.; Liang, J.; Deng, K.; Yao, J.; Wei, Z. Biomimetic Superhelical Conducting Microfibers with Homochirality for Enantioselective Sensing. J. Am. Chem. Soc. 2014, 136, 578–581.
226.
Xie, R.; Xu, P.; Liu, Y.; Li, L.; Luo, G.; Ding, M.; Liang, Q.; Xie, R.; Xu, P.; Liu, Y.; et al. Necklace-Like Microfibers with Variable Knots and Perfusable Channels Fabricated by an Oil-Free Microfluidic Spinning Process. Adv. Mater. 2018, 30, 1705082.
227.
Liu, Y.; Yang, L.; Chen, G.; Liu, Z.; Lu, T.; Yang, Y.; Yu, J.; Kang, D.; Yan, W.; He, M.; et al. PBAT Hollow Porous Microfibers Prepared via Electrospinning and Their Functionalization for Potential Peptide Release. Mater. Des. 2021, 207, 109880.
228.
Cao, X.; Chen, W.; Zhao, P.; Yang, Y.; Yu, D.G. Electrospun Porous Nanofibers: Pore−Forming Mechanisms and Applications for Photocatalytic Degradation of Organic Pollutants in Wastewater. Polymers 2022, 14, 3990.
229.
Xing, J.; Zhang, W.; Sun, S.; Liu, Z. Preparation of Porous Polylactic Acid Nanofibers and Application in Non-Electret High-Efficiency Filtration Composites. RSC Adv. 2024, 14, 14857–14867.
230.
Wagner, A.; Poursorkhabi, V.; Mohanty, A.K.; Misra, M. Analysis of Porous Electrospun Fibers from Poly(l-Lactic Acid)/Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Blends. ACS Sustain. Chem. Eng. 2014, 2, 1976–1982.
231.
Katsogiannis, K.A.G.; Vladisavljević, G.T.; Georgiadou, S. Porous Electrospun Polycaprolactone Fibers: Effect of Process Parameters. J. Polym. Sci. Part. B Polym. Phys. 2016, 54, 1878–1888.
232.
Huang, C.; Thomas, N.L. Fabricating Porous Poly(Lactic Acid) Fibres via Electrospinning. Eur. Polym. J. 2018, 99, 464–476.
233.
Katsogiannis, K.A.G.; Vladisavljević, G.T.; Georgiadou, S. Porous Electrospun Polycaprolactone (PCL) Fibres by Phase Separation. Eur. Polym. J. 2015, 69, 284–295.
234.
McNamara, M.C.; Niaraki-Asli, A.E.; Guo, J.; Okuzono, J.; Montazami, R.; Hashemi, N.N. Enhancing the Conductivity of Cell-Laden Alginate Microfibers with Aqueous Graphene for Neural Applications. Front. Mater. 2020, 7, 500340.
235.
Wang, Y.; Guo, J.; Luo, Z.; Shen, Y.; Wang, J.; Yu, Y.; Zhao, Y. Biopolymer-Assembled Porous Hydrogel Microfibers from Microfluidic Spinning for Wound Healing. Adv. Healthc. Mater. 2024, 13, 2302170.
236.
Song, T.; Shen, Q.; Cheng, Y.; Zhi, Y.; Liu, G.; Ren, H.; Wang, J. Mechanically Tunable Hydrogel Microfibers for Biomimetic Tumor Drug Testing. Adv. Funct. Mater. 2025, 2502840.
237.
Yu, Y.; Wen, H.; Ma, J.; Lykkemark, S.; Xu, H.; Qin, J. Flexible Fabrication of Biomimetic Bamboo-like Hybrid Microfibers. Adv. Mater. 2014, 26, 2494–2499.
238.
Cheung, T.W.; Li, L. A Review of Hollow Fibers in Application-Based Learning: From Textiles to Medical. Text. Res. J. 2019, 89, 237–253.
239.
Tian, Y.; Wang, Z.; Wang, L. Hollow Fibers: From Fabrication to Applications. Chem. Commun. 2021, 57, 9166–9177.
240.
Liu, H.; Wang, Y.; Chen, W.; Yu, Y.; Jiang, L.; Qin, J. A Microfluidic Strategy to Fabricate Ultra-Thin Polyelectrolyte Hollow Microfibers as 3D Cellular Carriers. Mater. Sci. Eng. C 2019, 104, 109705.
241.
Shi, L.; Hao, S.; Li, J.; Fan, L.; Li, W.; Chen, T.; Shi, J.; Yang, P.; Yu, Y.; Gao, S. Hydrogel-Based Hollow Microfibers for Functional Esophageal Carcinoma Remodeling. Cell Rep. Phys. Sci. 2025, 6, 102358.
242.
Liu, H.; Wang, Y.; Yu, Y.; Chen, W.; Jiang, L.; Qin, J. Simple Fabrication of Inner Chitosan-Coated Alginate Hollow Microfiber with Higher Stability. J. Biomed. Mater. Res. Part. B Appl. Biomater. 2019, 107, 2527–2536.
243.
Jiang, M.Y.; Ju, X.J.; Deng, K.; Fan, X.X.; He, X.H.; Wu, F.; He, F.; Liu, Z.; Wang, W.; Xie, R.; et al. The Microfluidic Synthesis of Composite Hollow Microfibers for K+-Responsive Controlled Release Based on a Host–Guest System. J. Mater. Chem. B 2016, 4, 3925–3935.
244.
Wang, M.; Ge, R.; Zhao, P.; Williams, G.R.; Yu, D.G.; Bligh, S.W.A. Exploring Wettability Difference-Driven Wetting by Utilizing Electrospun Chimeric Janus Microfiber Comprising Cellulose Acetate and Polyvinylpyrrolidone. Mater. Des. 2023, 226, 111652.
245.
Lee, K.J.; Park, T.H.; Hwang, S.; Yoon, J.; Lahann, J. Janus-Core and Shell Microfibers. Langmuir 2013, 29, 6181–6186.
246.
Tian, J.; Ma, Q.; Yu, W.; Li, D.; Dong, X.; Liu, G.; Wang, J. Preparation of Janus Microfibers with Magnetic and Fluorescence Functionality via Conjugate Electro-Spinning. Mater. Des. 2019, 170, 107701.
247.
Jia, L.; Han, F.; Yang, H.; Turnbull, G.; Wang, J.; Clarke, J.; Shu, W.; Guo, M.; Li, B. Microfluidic Fabrication of Biomimetic Helical Hydrogel Microfibers for Blood-Vessel-on-a-Chip Applications. Adv. Healthc. Mater. 2019, 8, 1900435.
248.
Teh, T.K.H.; Toh, S.L.; Goh, J.C.H. Aligned Fibrous Scaffolds for Enhanced Mechanoresponse and Tenogenesis of Mesenchymal Stem Cells. Tissue Eng.-Part A 2013, 19, 1360–1372.
249.
Tan, Y.; Yi, J.; Shi, P.; Wei, Q.; Cui, Y.; Guan, Y.; Cheng, H.; Su, T.; Yao, Q.; Liu, H.; et al. Extracellular Matrix-Modified Helix-Flexible Nerve Conduit with Optimal Mechanics and Nerve Regenerating Properties. Mater. Today Bio 2025, 35, 102501.
250.
Zhu, C.; Pongkitwitoon, S.; Qiu, J.; Thomopoulos, S.; Xia, Y. Design and Fabrication of a Hierarchically Structured Scaffold for Tendon-to-Bone Repair. Adv. Mater. 2018, 30, 1707306.
251.
Huang, D.; Li, Z.; Li, G.; Zhou, F.; Wang, G.; Ren, X.; Su, J. Biomimetic Structural Design in 3D-Printed Scaffolds for Bone Tissue Engineering. Mater. Today Bio 2025, 32, 101664.
252.
Liu, Y.; Wan, Y.; Li, C.; Guan, G.; Wang, F.; Gao, J.; Wang, L. Gradient Scaffolds in Bone-Soft Tissue Interface Engineering: Structural Characteristics, Fabrication Techniques, and Emerging Trends. J. Orthop. Transl. 2025, 50, 333–353.
253.
Cao, X.; Chen, R.; Wang, Z.; Zhang, H.; Ma, X.; Bao, F. Microfluidic Spun Self-Healable Janus-Core Composite Microfibers as Smart Fiber Actuators. ACS Appl. Mater. Interfaces 2025, 17, 20225–20235.
254.
Jeon, H.J.; Lee, H.; Kim, G.H. Nano-Sized Surface Patterns on Electrospun Microfibers Fabricated Using a Modified Plasma Process for Enhancing Initial Cellular Activities. Plasma Process. Polym. 2014, 11, 142–148.
255.
Meng, J.; Boschetto, F.; Yagi, S.; Marin, E.; Adachi, T.; Chen, X.; Pezzotti, G.; Sakurai, S.; Sasaki, S.; Aoki, T.; et al. Enhancing the Bioactivity of Melt Electrowritten PLLA Scaffold by Convenient, Green, and Effective Hydrophilic Surface Modification. Biomater. Adv. 2022, 135, 112686.
256.
Liu, S.M.; Chen, W.C.; Huang, S.M.; Chen, J.C.; Lin, C.L. Characterization of Electrospun Fibers and Electrospray Vancomycin-Containing Beads through the Interstitial or Lamellar Separation of Bead Composite Fiber Membranes to Evaluate Their Biomedical Application in Vitro. J. Ind. Text. 2022, 52. https://doi.org/10.1177/15280837221139326
257.
Jensen, B.N.; Wang, Y.; Le Friec, A.; Nabavi, S.; Dong, M.; Seliktar, D.; Chen, M. Wireless Electromagnetic Neural Stimulation Patch with Anisotropic Guidance. NPJ Flex. Electron. 2023, 7, 34.
258.
Truong, Y.B.; Glattauer, V.; Briggs, K.L.; Zappe, S.; Ramshaw, J.A.M. Collagen-Based Layer-by-Layer Coating on Electrospun Polymer Scaffolds. Biomaterials 2012, 33, 9198–9204.
259.
Can-Herrera, L.A.; Ávila-Ortega, A.; de la Rosa-García, S.; Oliva, A.I.; Cauich-Rodríguez, J.V.; Cervantes-Uc, J.M. Surface Modification of Electrospun Polycaprolactone Microfibers by Air Plasma Treatment: Effect of Plasma Power and Treatment Time. Eur. Polym. J. 2016, 84, 502–513.
260.
Correia, D.M.; Ribeiro, C.; Botelho, G.; Borges, J.; Lopes, C.; Vaz, F.; Carabineiro, S.A.C.; MacHado, A.V.; Lanceros-Méndez, S. Superhydrophilic Poly(l-Lactic Acid) Electrospun Membranes for Biomedical Applications Obtained by Argon and Oxygen Plasma Treatment. Appl. Surf. Sci. 2016, 371, 74–82.
261.
Sankar, D.; Shalumon, K.T.; Chennazhi, K.P.; Menon, D.; Jayakumar, R. Surface Plasma Treatment of Poly(Caprolactone) Micro, Nano, and Multiscale Fibrous Scaffolds for Enhanced Osteoconductivity. Tissue Eng. Part A 2014, 20, 1689–1702.
262.
Esmail, A.; Pereira, J.R.; Zoio, P.; Silvestre, S.; Menda, U.D.; Sevrin, C.; Grandfils, C.; Fortunato, E.; Reis, M.A.M.; Henriques, C.; et al. Oxygen Plasma Treated-Electrospun Polyhydroxyalkanoate Scaffolds for Hydrophilicity Improvement and Cell Adhesion. Polymers 2021, 13, 1056.
263.
Transito-Medina, J.; Vázquez-Vélez, E.; Castillo, M.C.; Martínez, H.; Campillo, B. Gentamicin Release Study in Uniaxial and Coaxial Polyhydroxybutyrate–Polyethylene Glycol–Gentamicin Microfibers Treated with Atmospheric Plasma. Polymers 2023, 15, 3889.
264.
El Khatib, M.; Mauro, A.; Wyrwa, R.; Di Mattia, M.; Turriani, M.; Di Giacinto, O.; Kretzschmar, B.; Seemann, T.; Valbonetti, L.; Berardinelli, P.; et al. Fabrication and Plasma Surface Activation of Aligned Electrospun Plga Fiber Fleeces with Improved Adhesion and Infiltration of Amniotic Epithelial Stem Cells Maintaining Their Teno-Inductive Potential. Molecules 2020, 25, 3176.
265.
Kim, S.; Sitti, M. Biologically Inspired Polymer Microfibers with Spatulate Tips as Repeatable Fibrillar Adhesives. Appl. Phys. Lett. 2006, 89, 261911.
266.
Gharib, G.; Bütün, İ.; Muganlı, Z.; Kozalak, G.; Namlı, İ.; Sarraf, S.S.; Ahmadi, V.E.; Toyran, E.; Wijnen, A.J.; Koşar, A. Biomedical Applications of Microfluidic Devices: A Review. Biosensors 2022, 12, 1023.
267.
Boda, S.K.; Chen, S.; Chu, K.; Kim, H.J.; Xie, J. Electrospraying Electrospun Nanofiber Segments into Injectable Microspheres for Potential Cell Delivery. ACS Appl. Mater. Interfaces 2018, 10, 25069–25079.
268.
Xie, J.; Wang, C.H. Electrospray in the Dripping Mode for Cell Microencapsulation. J. Colloid Interface Sci. 2007, 312, 247–255.
269.
Stankevich, K.S.; Kudryavtseva, V.L.; Bolbasov, E.N.; Shesterikov, E.V.; Larionova, I.V.; Shapovalova, Y.G.; Domracheva, L.V.; Volokhova, A.A.; Kurzina, I.A.; Zhukov, Y.M.; et al. Modification of PCL Scaffolds by Reactive Magnetron Sputtering: A Possibility for Modulating Macrophage Responses. ACS Biomater. Sci. Eng. 2020, 6, 3967–3974.
270.
Fiaschini, N.; Giuliani, C.; Vitali, R.; Tammaro, L.; Valerini, D.; Rinaldi, A. Design and Manufacturing of Antibacterial Electrospun Polysulfone Membranes Functionalized by Ag Nanocoating via Magnetron Sputtering. Nanomaterials 2022, 12, 3962.
271.
Kalakonda, P.; Thudumu, S.; Mynepally, S.L.; Mandal, P.; Banne, S.; Kalakonda, P.B.; Podili, B.B. Engineering Micro/Nano-Fibrous Scaffolds with Silver Coating for Tailored Wound Repair Applications. J. Nanopart. Res. 2023, 25, 254.
272.
Zhang, H.; Cao, Y.; Zhen, Q.; Hu, J.J.; Cui, J.Q.; Qian, X.M. Facile Preparation of PET/PA6 Bicomponent Microfilament Fabrics with Tunable Porosity for Comfortable Medical Protective Clothing. ACS Appl. Bio Mater. 2022, 5, 3509–3518.
273.
Joseph, E.; Patil, A.; Hirlekar, S.; Shete, A.; Parekh, N.; Prabhune, A.; Nisal, A. Glycomonoterpene-Functionalized Crack-Resistant Biocompatible Silk Fibroin Coatings for Biomedical Implants. ACS Appl. Bio Mater. 2019, 2, 675–684.
274.
Innocent, M.; Zhai, G.; Innocent, M.T.; Zhou, J.; Dai, X.; Jiang, T.; Wang, J.; Xiang, H.; Zhu, M. Bifunctional Catechol-Based Coating Strategy to Construct Highly Effective Antimicrobial Polyethylene Microfibers for Personal Protective Equipment. Prog. Org. Coat. 2025, 198, 108916.
275.
McCarthy, A.; Avegnon, K.L.M.; Holubeck, P.A.; Brown, D.; Karan, A.; Sharma, N.S.; John, J.V.; Weihs, S.; Ley, J.; Xie, J. Electrostatic Flocking of Salt-Treated Microfibers and Nanofiber Yarns for Regenerative Engineering. Mater. Today Bio 2021, 12, 100166.
276.
Hosseini, V.; Evrova, O.; Hoerstrup, S.P.; Vogel, V.; Hosseini, V.; Evrova, O.; Vogel, V.; Hoerstrup, S.P. A Simple Modification Method to Obtain Anisotropic and Porous 3D Microfibrillar Scaffolds for Surgical and Biomedical Applications. Small 2018, 14, 1702650.
277.
Schneider, R.; Facure, M.H.M.; Chagas, P.A.M.; Andre, R.S.; dos Santos, D.M.; Correa, D.S. Tailoring the Surface Properties of Micro/Nanofibers Using 0D, 1D, 2D, and 3D Nanostructures: A Review on Post-Modification Methods. Adv. Mater. Interfaces 2021, 8, 2100430.
278.
Xiao, F.X.; Pagliaro, M.; Xu, Y.J.; Liu, B. Layer-by-Layer Assembly of Versatile Nanoarchitectures with Diverse Dimensionality: A New Perspective for Rational Construction of Multilayer Assemblies. Chem. Soc. Rev. 2016, 45, 3088–3121.
279.
Ravikrishnan, A.; Zhang, H.; Fox, J.M.; Jia, X. Core–Shell Microfibers via Bioorthogonal Layer-by-Layer Assembly. ACS Macro Lett. 2020, 9, 1369–1375.
280.
Ariga, K.; Lvov, Y.; Decher, G. There Is Still Plenty of Room for Layer-by-Layer Assembly for Constructing Nanoarchitectonics-Based Materials and Devices. Phys. Chem. Chem. Phys. 2022, 24, 4097–4115.
281.
Wang, J.; Wang, H.; Mo, X.; Wang, H. Reduced Graphene Oxide-Encapsulated Microfiber Patterns Enable Controllable Formation of Neuronal-Like Networks. Adv. Mater. 2020, 32, 2004555.
282.
Gilbert-Honick, J.; Iyer, S.R.; Somers, S.M.; Takasuka, H.; Lovering, R.M.; Wagner, K.R.; Mao, H.Q.; Grayson, W.L. Engineering 3D Skeletal Muscle Primed for Neuromuscular Regeneration Following Volumetric Muscle Loss. Biomaterials 2020, 255, 120154.
283.
Obata, A.; Hotta, T.; Wakita, T.; Ota, Y.; Kasuga, T. Electrospun Microfiber Meshes of Silicon-Doped Vaterite/Poly(Lactic Acid) Hybrid for Guided Bone Regeneration. Acta Biomater. 2010, 6, 1248–1257.
284.
Shahriar, S.M.S.; Tran, H.Q.; Hayati, F.; Andrabi, S.M.; Yan, Z.; Rather, I.I.G.; Sharma, N.S.; Xie, J. Swallowable Expandable Fibrous Capsules for Nonendoscopic Sampling of Esophageal Cells. Sci. Adv. 2025, 11, eaeb3892.
285.
Xu, Y.; Cui, W.; Zhang, Y.; Zhou, P.; Gu, Y.; Shen, X.; Li, B.; Chen, L. Hierarchical Micro/Nanofibrous Bioscaffolds for Structural Tissue Regeneration. Adv. Healthc. Mater. 2017, 6, 1601457.
286.
Lund, A.; Rundqvist, K.; Nilsson, E.; Yu, L.; Hagström, B.; Müller, C. Energy Harvesting Textiles for a Rainy Day: Woven Piezoelectrics Based on Melt-Spun PVDF Microfibres with a Conducting Core. NPJ Flex. Electron. 2018, 2, 9.
287.
Zhou, Y.; He, J.; Wang, H.; Qi, K.; Nan, N.; You, X.; Shao, W.; Wang, L.; Ding, B.; Cui, S. Highly Sensitive. Self-Powered and Wearable Electronic Skin Based on Pressure-Sensitive Nanofiber Woven Fabric Sensor. Sci. Rep. 2017, 7, 12949.
288.
Fan, W.; He, Q.; Meng, K.; Tan, X.; Zhou, Z.; Zhang, G.; Yang, J.; Wang, Z.L. Machine-Knitted Washable Sensor Array Textile for Precise Epidermal Physiological Signal Monitoring. Sci. Adv. 2020, 6, 2840.
289.
Mokhtari, F.; Foroughi, J.; Zheng, T.; Cheng, Z.; Spinks, G.M. Triaxial Braided Piezo Fiber Energy Harvesters for Self-Powered Wearable Technologies. J. Mater. Chem. A 2019, 7, 8245–8257.
290.
Girard, F.; Lajoye, C.; Camman, M.; Tissot, N.; Berthelot Pedurand, F.; Tandon, B.; Moedder, D.; Liashenko, I.; Salameh, S.; Dalton, P.D.; et al. First Advanced Bilayer Scaffolds for Tailored Skin Tissue Engineering Produced via Electrospinning and Melt Electrowriting. Adv. Funct. Mater. 2024, 34, 2314757.
291.
Lu, Z.; Zhang, H.; Hu, X.; Lu, J.; Wang, D. Probiotic-Free Microfiber Membrane for Promoting Infected Wound Healing by Regulating Wound Flora Balance. ACS Mater. Lett. 2022, 4, 2547–2554.
292.
Wang, C.; Su, Y.; Xie, J. Advances in Electrospun Nanofibers: Versatile Materials and Diverse Biomedical Applications. Accounts Mater. Res. 2024, 5, 987–999.
293.
Chen, S.; Liu, B.; Carlson, M.A.; Gombart, A.F.; Reilly, D.A.; Xie, J. Recent Advances in Electrospun Nanofibers for Wound Healing. Nanomedicine 2017, 12, 1335–1352.
294.
Huang, Q.; Wu, T.; Wang, L.; Zhu, J.; Guo, Y.; Yu, X.; Fan, L.; Xin, J.H.; Yu, H. A Multifunctional 3D Dressing Unit Based on the Core-Shell Hydrogel Microfiber for Diabetic Foot Wound Healing. Biomater. Sci. 2022, 10, 2568–2576.
295.
Wang, X.; Sun, K.; Wang, C.; Yang, M.; Qian, K.; Ye, B.; Guo, X.; Shao, Y.; Chu, C.; Xue, F.; et al. Ultrasound-Responsive Microfibers Promoted Infected Wound Healing with Neuro-Vascularization by Segmented Sonodynamic Therapy and Electrical Stimulation. Biomaterials 2025, 313, 122803.
296.
Hema Naveena, A.; Kumar, A.; Agrawal, A.; Mavely, L.; Bhatia, D. Characterization of a Bioactive Chitosan Dressing: A Comprehensive Solution for Different Wound Healing Phases. ACS Appl. Bio Mater. 2025, 8, 1921–1933.
297.
Nakayama, K.H.; Shayan, M.; Huang, N.F. Engineering Biomimetic Materials for Skeletal Muscle Repair and Regeneration. Adv. Healthc. Mater. 2019, 8, 1801168.
298.
Li, J.; Wang, Y.; Wang, X.; Shang, L.; Zhao, Y.; Zhang, H. Photo-Responsive Antibacterial Patches Composed of Liquid Metal-Encapsulated Core-Shell Microfibers for Wound Healing. Chem. Eng. J. 2025, 516, 164218.
299.
Yang, X.; Li, W.; Liu, Y.; Cao, N.; He, Y.; Sun, Q.; Zhou, S. Charged Fibrous Dressing to Promote Diabetic Chronic Wound Healing. Adv. Healthc. Mater. 2024, 13, 2302183.
300.
Xue, J.; Wu, T.; Xia, Y. Perspective: Aligned Arrays of Electrospun Nanofibers for Directing Cell Migration. APL Mater. 2018, 6, 120902.
301.
Zhang, X.; Hao, R.; Tong, J.; Hu, H.; Du, J.; Gong, B.; Tian, F.; Lu, Y.; Xue, J. A Radially Aligned Nanofiber Scaffold with Engineered Guidance Gradients for Directed Cell Migration and Accelerated Wound Healing. Biomaterials 2026, 327, 123797.
302.
Homaeigohar, S.; Li, M.; Boccaccini, A.R. Bioactive Glass-Based Fibrous Wound Dressings. Burn. Trauma 2022, 1, tkac038.
303.
Meng, Q.; Li, C.; Jiang, J.; Guo, F.; Fu, Y.; Gu, S.; Jiang, T.; Pan, J.; Zeng, Y.; Sun, L.; et al. A Fibrous Dressing Integrating Advanced Nanomicro Hybrid Structure with Effective Drug Delivery for Accelerated Wound Healing. ACS Appl. Bio Mater. 2025, 9, 315–332.
304.
Kou, J.; Li, Y.; Zhou, C.; Wang, X.; Ni, J.; Lin, Y.; Ge, H.; Zheng, D.; Chen, G.; Sun, X.; et al. Electrospinning in Promoting Chronic Wound Healing: Materials, Process, and Applications. Front. Bioeng. Biotechnol. 2025, 6, 1550553.
305.
Shen, Y.; Liu, Y.; Nunes, J.K.; Wang, C.; Xu, M.; To, M.K.T.; Stone, H.A.; Shum, H.C. Fibro-Gel: An All-Aqueous Hydrogel Consisting of Microfibers with Tunable Release Profile and Its Application in Wound Healing. Adv. Mater. 2023, 35, 2211637.
306.
Yu, Y.; Chen, G.; Guo, J.; Liu, Y.; Ren, J.; Kong, T.; Zhao, Y. Vitamin Metal-Organic Framework-Laden Microfibers from Microfluidics for Wound Healing. Mater. Horizons 2018, 5, 1137–1142.
307.
Ha, J.H.; Kim, J.Y.; Kim, D.; Ahn, J.; Jeong, Y.; Ko, J.; Hwang, S.; Jeon, S.; Jung, Y.; Gu, J.; et al. Multifunctional Micro/Nanofiber Based-Dressing Patch with Healing, Protection, and Monitoring Capabilities for Advanced Wound Care. Adv. Mater. Technol. 2023, 8, 2201765.
308.
Tan, L.; Fu, J.; Feng, F.; Liu, X.; Cui, Z.; Li, B.; Han, Y.; Zheng, Y.; Yeung, K.W.K.; Li, Z.; et al. Engineered Probiotics Biofilm Enhances Osseointegration via Immunoregulation and Anti-Infection. Sci. Adv. 2020, 6, 5723–5736.
309.
Xu, Z.; Shi, L.; Yang, M.; Zhang, H.; Zhu, L. Fabrication of a Novel Blended Membrane with Chitosan and Silk Microfibers for Wound Healing: Characterization, in Vitro and in Vivo Studies. J. Mater. Chem. B 2015, 3, 3634–3642.
310.
Sharma, N.S.; Hayati, F.; Andrabi, S.M.; Su, Y.; Mondal, B.; Xie, J. Functional Nanofiber Scaffolds Enabling Local Immunomodulation and Inhibition of Ectopic Bone Formation. ACS Appl. Mater. Interfaces 2026, 18, 9559–9572.
311.
Shi, L.; Wang, F.; Zhu, W.; Xu, Z.; Fuchs, S.; Hilborn, J.; Zhu, L.; Ma, Q.; Wang, Y.; Weng, X.; et al. Self-Healing Silk Fibroin-Based Hydrogel for Bone Regeneration: Dynamic Metal-Ligand Self-Assembly Approach. Adv. Funct. Mater. 2017, 27, 1700591.
312.
Wang, J.; Yang, Q.; Saiding, Q.; Chen, L.; Liu, M.; Wang, Z.; Xiang, L.; Deng, L.; Chen, Y.; Cui, W.; et al. Geometric Angles and Gene Expression in Cells for Structural Bone Regeneration. Adv. Sci. 2023, 10, 2304111.
313.
Zhou, Y.H.; Zou, Z.H.; Teng, J.X.; Wu, Z.Y.; Luo, S.W.; Ning, X.; Ye, C.; Yang, L.; Toh, W.S. Injectable Alginate/β-TCP Composite Hydrogel Incorporating P34HB/MgO+PEG Coaxial Electrospun Microfibers for Minimally Invasive Treatment of Osteonecrosis. Adv. Healthc. Mater. 2025, 14, 2500617.
314.
Xu, Z.; Shi, L.; Hu, D.; Hu, B.; Yang, M.; Zhu, L. Formation of Hierarchical Bone-like Apatites on Silk Microfiber Templates via Biomineralization. RSC Adv. 2016, 6, 76426–76433.
315.
Yan, Z.; Tran, H.; Ma, D.; Xie, J. Emerging Piezoelectric Metamaterials for Biomedical Applications. Mater. Interfaces 2024, 1, 13–34.
316.
Zhou, Y.; Jiao, Z.; Zhang, H.; Zhao, G.; Zhao, Z.; Li, C.; Zhang, P.; Zhao, L.; Zhao, Y.; Wu, G. Collagen-Enhanced Piezoelectric PLLA/ZnO Microfiber Barrier Membranes for Superior Bone Regeneration. Int. J. Biol. Macromol. 2025, 319, 145443.
317.
Somers, S.M.; Zhang, N.Y.; Morrissette-McAlmon, J.B.F.; Tran, K.; Mao, H.Q.; Grayson, W.L. Myoblast Maturity on Aligned Microfiber Bundles at the Onset of Strain Application Impacts Myogenic Outcomes. Acta Biomater. 2019, 94, 232–242.
318.
Kamaraj, M.; Rezayof, O.; Barer, A.; Kim, H.; Moghimi, N.; Joshi, A.; Dokmeci, M.R.; Khademhosseini, A.; Alambeigi, F.; John, J.V. Development of Silk Microfiber-Reinforced Bioink for Muscle Tissue Engineering and in Situ Printing by a Handheld 3D Printer. Biomater. Adv. 2025, 166, 214057.
319.
Gilbert-Honick, J.; Ginn, B.; Zhang, Y.; Salehi, S.; Wagner, K.R.; Mao, H.Q.; Grayson, W.L. Adipose-Derived Stem/Stromal Cells on Electrospun Fibrin Microfiber Bundles Enable Moderate Muscle Reconstruction in a Volumetric Muscle Loss Model. Cell Transplant. 2018, 27, 1644–1656.
320.
Chen, X.; Du, W.; Cai, Z.; Ji, S.; Dwivedi, M.; Chen, J.; Zhao, G.; Chu, J. Uniaxial Stretching of Cell-Laden Microfibers for Promoting C2C12 Myoblasts Alignment and Myofibers Formation. ACS Appl. Mater. Interfaces 2020, 12, 2162–2170.
321.
Campiglio, C.E.; Carcano, A.; Draghi, L. RGD-Pectin Microfiber Patches for Guiding Muscle Tissue Regeneration. J. Biomed. Mater. Res. Part A 2022, 110, 515–524.
322.
Li, M.; Deng, W.; Zhang, J.; Zheng, W.; Yu, T.; Zhou, Q. Aligned Electrospun PLLA/Graphene Microfibers with Nanotopographical Surface Modulate the Mitochondrial Responses of Vascular Smooth Muscle Cells. Adv. Mater. Interfaces 2021, 8, 2100229.
323.
Uribe-Gomez, J.; Posada-Murcia, A.; Shukla, A.; Ergin, M.; Constante, G.; Apsite, I.; Martin, D.; Schwarzer, M.; Caspari, A.; Synytska, A.; et al. Shape-Morphing Fibrous Hydrogel/Elastomer Bilayers Fabricated by a Combination of 3D Printing and Melt Electrowriting for Muscle Tissue Regeneration. ACS Appl. Bio Mater. 2021, 4, 1720–1730.
324.
Nam, S.; Seo, B.R.; Najibi, A.J.; McNamara, S.L.; Mooney, D.J. Active Tissue Adhesive Activates Mechanosensors and Prevents Muscle Atrophy. Nat. Mater. 2022, 22, 249–259.
325.
Christensen, K.W.; Turner, J.; Coughenour, K.; Maghdouri-White, Y.; Bulysheva, A.A.; Sergeant, O.; Rariden, M.; Randazzo, A.; Sheean, A.J.; Christ, G.J.; et al. Fiber Bioprinted Implants with Musculoskeletal Tissue Properties Promote Functional Recovery in Volumetric Muscle Loss. Adv. Healthc. Mater. 2022, 11, 2101357.
326.
Kim, W.J.; Kim, M.; Kim, G.H. 3D-Printed Biomimetic Scaffold Simulating Microfibril Muscle Structure. Adv. Funct. Mater. 2018, 28, 1800405.
327.
Chen, Y.; Guo, C.; Manousiouthakis, E.; Wang, X.; Cairns, D.M.; Roh, T.T.; Du, C.; Kaplan, D.L. Bi-Layered Tubular Microfiber Scaffolds as Functional Templates for Engineering Human Intestinal Smooth Muscle Tissue. Adv. Funct. Mater. 2020, 30, 2000543.
328.
Chen, X.; Sun, T.; Shimoda, S.; Wang, H.; Huang, Q.; Fukuda, T.; Shi, Q.; Chen, X.; Sun, T.; Wang, H.; et al. A Micromanipulation-Actuated Large-Scale Screening to Identify Optimized Microphysiological Model Parameters in Skeletal Muscle Regeneration. Adv. Sci. 2024, 11, 2403622.
329.
Xie, J.; MacEwan, M.R.; Li, X.; Sakiyama-Elbert, S.E.; Xia, Y. Neurite Outgrowth on Nanofiber Scaffolds with Different Orders, Structures, and Surface Properties. ACS Nano 2009, 3, 1151–1159.
330.
Zhang, C.; Gong, J.; Zhang, J.; Zhu, Z.; Qian, Y.; Lu, K.; Zhou, S.; Gu, T.; Wang, H.; He, Y.; et al. Three Potential Elements of Developing Nerve Guidance Conduit for Peripheral Nerve Regeneration. Adv. Funct. Mater. 2023, 33, 2302251.
331.
Puhl, D.L.; Funnell, J.L.; Nelson, D.W.; Gottipati, M.K.; Gilbert, R.J. Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration. Bioengineering 2021, 8, 4.
332.
Fang, Y.; Wang, C.; Liu, Z.; Ko, J.; Chen, L.; Zhang, T.; Xiong, Z.; Zhang, L.; Sun, W. 3D Printed Conductive Multiscale Nerve Guidance Conduit with Hierarchical Fibers for Peripheral Nerve Regeneration. Adv. Sci. 2023, 10, 2205744.
333.
Dong, X.; Liu, S.; Yang, Y.; Gao, S.; Li, W.; Cao, J.; Wan, Y.; Huang, Z.; Fan, G.; Chen, Q.; et al. Aligned Microfiber-Induced Macrophage Polarization to Guide Schwann-Cell-Enabled Peripheral Nerve Regeneration. Biomaterials 2021, 272, 120767.
334.
Kim, T.; Jeon, J.; Lee, M.S.; Park, J.H.; Chung, Y.; Yang, H.S. Development of Electrospun Nerve Guidance Conduits by a Milk-Derived Protein with Biodegradable Polymers for Peripheral Nerve Regeneration. ACS Appl. Bio Mater. 2025, 8, 3498–3512.
335.
Yao, S.; He, F.; Cao, Z.; Sun, Z.; Chen, Y.; Zhao, H.; Yu, X.; Wang, X.; Yang, Y.; Rosei, F.; et al. Mesenchymal Stem Cell-Laden Hydrogel Microfibers for Promoting Nerve Fiber Regeneration in Long-Distance Spinal Cord Transection Injury. ACS Biomater. Sci. Eng. 2020, 6, 1165–1175.
336.
Nakielski, P.; Pierini, F. Blood Interactions with Nano- and Microfibers: Recent Advances, Challenges and Applications in Nano- and Microfibrous Hemostatic Agents. Acta Biomater. 2019, 84, 63–76.
337.
Zhang, F.; King, M.W. Immunomodulation Strategies for the Successful Regeneration of a Tissue-Engineered Vascular Graft. Adv. Healthc. Mater. 2022, 11, 2200045.
338.
Ravi, S.; Chaikof, E.L. Biomaterials for Vascular Tissue Engineering. Regen. Med. 2010, 5, 107–120.
339.
Liu, S.; Yao, L.; Wang, Y.; Li, Y.; Jia, Y.; Yang, Y.; Li, N.; Hu, Y.; Kong, D.; Dong, X.; et al. Immunomodulatory Hybrid Micro-Nanofiber Scaffolds Enhance Vascular Regeneration. Bioact. Mater. 2023, 21, 464–482.
340.
Fahad, M.A.Al; Lee, H.Y.; Park, S.; Choi, M.; Shanto, P.C.; Park, M.; Bae, S.H.; Lee, B.T. Small-Diameter Vascular Graft Composing of Core-Shell Structured Micro-Nanofibers Loaded with Heparin and VEGF for Endothelialization and Prevention of Neointimal Hyperplasia. Biomaterials 2024, 306, 122507.
341.
Wang, H.; Cui, L.; Luo, Y.; Chen, H.; Liu, X.; Shi, Q. Inflammation-Responsive PCL/Gelatin Microfiber Scaffold with Sustained Nitric Oxide Generation and Heparin Release for Blood-Contacting Implants. Int. J. Biol. Macromol. 2024, 281, 136544.
342.
Li, P.; Shahriar, S.M.S.; Tang, L.; Prachyl, H.; Chaliki, H.; Scott, L.; Xie, J.; Zhu, W. Minimally Invasive Delivery of Engineered Heart Tissues Restores Cardiac Function in Rats with Chronic Myocardial Infarction. Acta Biomater. 2026, 211, 74–91.
343.
Federici, A.S.; Garcia, O.; Kelly, D.J.; Hoey, D.A. Muticomponent Melt-Electrowritten Vascular Graft to Mimic and Guide Regeneration of Small Diameter Blood Vessels. Adv. Funct. Mater. 2024, 34, 2409883.
344.
Wang, Q.; Zhang, Y.; Shao, F.; Yang, X.; Wang, S.; Shen, Y.; Wang, H. Bio-Inspired Design of 4D-Printed Scaffolds Capable of Programmable Multi-Step Transformations Toward Vascular Reconstruction. Adv. Funct. Mater. 2024, 34, 2407592.
345.
Wang, H.; Xing, M.; Deng, W.; Qian, M.; Wang, F.; Wang, K.; Midgley, A.C.; Zhao, Q. Anti-Sca-1 Antibody-Functionalized Vascular Grafts Improve Vascular Regeneration via Selective Capture of Endogenous Vascular Stem/Progenitor Cells. Bioact. Mater. 2022, 16, 433–450.
346.
Wu, Z.; Cai, H.; Ao, Z.; Xu, J.; Heaps, S.; Guo, F. Microfluidic Printing of Tunable Hollow Microfibers for Vascular Tissue Engineering. Adv. Mater. Technol. 2021, 6, 2000683.
347.
Sun, T.; Shi, Q.; Huang, Q.; Wang, H.; Xiong, X.; Hu, C.; Fukuda, T. Magnetic Alginate Microfibers as Scaffolding Elements for the Fabrication of Microvascular-like Structures. Acta Biomater. 2018, 66, 272–281.
348.
Yu, L.; Feng, Y.; Yao, L.; Soon, R.H.; Yeo, J.C.; Lim, C.T. Dual-Core Capacitive Microfiber Sensor for Smart Textile Applications. ACS Appl. Mater. Interfaces 2019, 11, 33347–33355.
349.
Zhao, Y.; Zhai, Q.; Dong, D.; An, T.; Gong, S.; Shi, Q.; Cheng, W. Highly Stretchable and Strain-Insensitive Fiber-Based Wearable Electrochemical Biosensor to Monitor Glucose in the Sweat. Anal. Chem. 2019, 91, 6569–6576.
350.
Chinnamani, M.V.; Hanif, A.; Kannan, P.K.; Kaushal, S.; Sultan, M.J.; Lee, N.E. Soft Microfiber-Based Hollow Microneedle Array for Stretchable Microfluidic Biosensing Patch with Negative Pressure-Driven Sampling. Biosens. Bioelectron. 2023, 237, 115468.
351.
Jiang, C.; Dai, P.; Li, X.; Cong, Z.; Dong, T.; Sun, Y.; Liu, X.; Sui, Y.; Chen, P.; Yu, X.; et al. Flexible Wearable Microfiber Respiratory Sensor Based on Microspheres Coupling. IEEE Sens. J. 2023, 23, 27324–27330.
352.
Yu, R.; Wu, L.; Yang, Z.; Wu, J.; Chen, H.; Pan, S.; Zhu, M. Dynamic Liquid Metal–Microfiber Interlocking Enables Highly Conductive and Strain-Insensitive Metastructured Fibers for Wearable Electronics. Adv. Mater. 2025, 37, 2415268.
353.
Gao, J.; Fan, Y.; Zhang, Q.; Luo, L.; Hu, X.; Li, Y.; Song, J.; Jiang, H.; Gao, X.; Zheng, L.; et al. Ultra-Robust and Extensible Fibrous Mechanical Sensors for Wearable Smart Healthcare. Adv. Mater. 2022, 34, 2107511.
354.
Hanif, A.; Park, J.; Kim, D.; Youn, J.; Jeong, U.; Kim, D.S. A Stretchable and Strain-Limiting, Bio-Inspired Nanofiber-Reinforced Microfiber for Wearable Electronics. Adv. Mater. Technol. 2024, 9, 2301643.
355.
Jiang, Q.; Ma, X.; Chai, Y.; Ma, H.; Tang, F.; Hua, K.; Chen, R.; Jin, Z.; Wang, X.; Ji, J.; et al. Reduced Graphene Oxide-Polypyrrole Aerogel-Based Coaxial Heterogeneous Microfiber Enables Ultrasensitive Pressure Monitoring of Living Organisms. ACS Appl. Mater. Interfaces 2021, 13, 5425–5434.
356.
Kim, J.; Roh, H.; Moon, S.; Jeon, C.; Baek, S.; Cho, W.; Sim, J.Y.; Jeong, U. Wireless Breathable Face Mask Sensor for Spatiotemporal 2D Respiration Profiling and Respiratory Diagnosis. Biomaterials 2024, 309, 122579.
357.
Hou, W.; Wang, J.; Lv, J.an. Bioinspired Liquid Crystalline Spinning Enables Scalable Fabrication of High-Performing Fibrous Artificial Muscles. Adv. Mater. 2023, 35, 2211800.
358.
Kim, H.; Na, H.; Noh, S.; Chang, S.; Kim, J.; Kong, T.; Shin, G.; Lee, C.; Lee, S.; Park, Y.L.; et al. Inherently Integrated Microfiber-Based Flexible Proprioceptive Sensor for Feedback-Controlled Soft Actuators. NPJ Flex. Electron. 2024, 8, 15.
359.
Chen, S.; Boda, S.K.; Batra, S.K.; Li, X.; Xie, J. Emerging Roles of Electrospun Nanofibers in Cancer Research. Adv. Healthc. Mater. 2018, 7, 1701024.
360.
Tian, L.; Ma, J.; Li, W.; Zhang, X.; Gao, X. Microfiber Fabricated via Microfluidic Spinning toward Tissue Engineering Applications. Macromol. Biosci. 2023, 23, 2200429.
361.
Neufeld, L.; Yeini, E.; Pozzi, S.; Satchi-Fainaro, R. 3D Bioprinted Cancer Models: From Basic Biology to Drug Development. Nat. Rev. Cancer 2022, 22, 679–692.
362.
Zhao, J.; Cui, W. Functional Electrospun Fibers for Local Therapy of Cancer. Adv. Fiber Mater. 2020, 2, 229–245.
363.
Chen, Y.; Guo, J.; Wu, X.; Xu, Y.; Wang, J.; Ren, H.; Zhao, Y. Microfluidic Spinning of Natural Origin Microfibers for Breast Tumor Postsurgical Treatment. Chem. Eng. J. 2023, 472, 144901.
364.
Huo, J.; Zou, J.; Ma, H.; Meng, G.; Huang, Y.; Yan, X.; Yang, Y.; Zhang, M. Astragaloside IV Microfibers Assembling into Injectable 3D-Scaffolds with Intrinsic Immunoactivity for Enhanced Tumor Vaccine Efficacy. Chem. Eng. J. 2024, 498, 155511.
365.
Sharma, P.; Shin, J.B.; Park, B.C.; Lee, J.W.; Byun, S.W.; Jang, N.Y.; Kim, Y.J.; Kim, Y.; Kim, Y.K.; Cho, N.H. Application of Radially Grown ZnO Nanowires on Poly-L-Lactide Microfibers Complexed with a Tumor Antigen for Cancer Immunotherapy. Nanoscale 2019, 11, 4591–4600.
366.
Jing, L.; Wang, X.; Leng, B.; Zhan, N.; Liu, H.; Wang, S.; Lu, Y.; Sun, J.; Huang, D. Engineered Nanotopography on the Microfibers of 3D-Printed PCL Scaffolds to Modulate Cellular Responses and Establish an in Vitro Tumor Model. ACS Appl. Bio Mater. 2021, 4, 1381–1394.
367.
Lee, C.T.; Gill, E.L.; Wang, W.; Gerigk, M.; Terentjev, E.M.; Shery Huang, Y.Y. Guided Assembly of Cancer Ellipsoid on Suspended Hydrogel Microfibers Estimates Multi-Cellular Traction Force. Phys. Biol. 2021, 18, 036001.
368.
Shiroud Heidari, B.; Dodda, J.M.; El-Khordagui, L.K.; Focarete, M.L.; Maroti, P.; Toth, L.; Pacilio, S.; El-Habashy, S.E.; Boateng, J.; Catanzano, O.; et al. Emerging Materials and Technologies for Advancing Bioresorbable Surgical Meshes. Acta Biomater. 2024, 184, 1–21.
369.
Pluchino, M.; Vivarelli, L.; Giavaresi, G.; Dallari, D.; Govoni, M. Commercial Biomaterial-Based Products for Tendon Surgical Augmentation: A Scoping Review on Currently Available Medical Devices. J. Funct. Biomater. 2025, 16, 130.
370.
Baylón, K.; Rodríguez-Camarillo, P.; Elías-Zúñiga, A.; Díaz-Elizondo, J.A.; Gilkerson, R.; Lozano, K.Past. Present and Future of Surgical Meshes: A Review. Membranes 2017, 22, 47.
371.
Plencner, M.; East, B.; Tonar, Z.; Otáhal, M.; Prosecká, E.; Rampichová, M.; Krejčí, T.; Litvinec, A.; Buzgo, M.; Míčková, A.; et al. Abdominal Closure Reinforcement by Using Polypropylene Mesh Functionalized with Poly-Ԑ-Caprolactone Nanofibers and Growth Factors for Prevention of Incisional Hernia Formation. Int. J. Nanomed. 2014, 9, 3263–3277.
372.
Cazzagon, V.; Giubilato, E.; Bonetto, A.; Blosi, M.; Zanoni, I.; Costa, A.L.; Vineis, C.; Varesano, A.; Marcomini, A.; Hristozov, D.; et al. Identification of the Safe(r) by Design Alternatives for Nanosilver-Enabled Wound Dressings. Front. Bioeng. Biotechnol. 2022, 10, 987650.
373.
Williams, S.F.; Martin, D.P.; Moses, A.C. The History of GalaFLEX P4HB Scaffold. Aesthetic Surg. J. 2016, 36, 33–42.
374.
Williams, S.F.; Rizk, S.; Martin, D.P. Poly-4-Hydroxybutyrate (P4HB): A New Generation of Resorbable Medical Devices for Tissue Repair and Regeneration. Biomed. Eng. 2013, 58, 439–452.
375.
Martin, D.P.; Badhwar, A.; Shah, D.V.; Rizk, S.; Eldridge, S.N.; Gagne, D.H.; Ganatra, A.; Darois, R.E.; Williams, S.F.; Tai, H.C.; et al. Characterization of Poly-4-Hydroxybutyrate Mesh for Hernia Repair Applications. J. Surg. Res. 2013, 184, 766–773.
376.
Deeken, C.R.; Gagne, D.H.; Badhwar, A. Mechanical and Histological Characteristics of PhasixTM ST Mesh in a Porcine Model of Hernia Repair. J. Investig. Surg. 2022, 35, 415–423.
377.
Gómez-Gil, V.; Rodríguez, M.; García-Moreno Nisa, F.; Pérez-Köhler, B.; Pascual, G. Evaluation of Synthetic Reticular Hybrid Meshes Designed for Intraperitoneal Abdominal Wall Repair Preclinical and In Vitro Behavior. PLoS One 2019 14, 0213005.
378.
Horii, T.; Tsujimoto, H.; Hagiwara, A.; Isogai, N.; Sueyoshi, Y.; Oe, Y.; Kageyama, S.; Yoshida, T.; Kobayashi, K.; Minato, H.; et al. Effects of Fiber Diameter and Spacing Size of an Artificial Scaffold on the In Vivo Cellular Response and Tissue Remodeling. ACS Appl. Bio Mater. 2021, 4, 6924–6936.
379.
Minsart, M.; Vlierberghe, S.; Dubruel, P.; Mignon, A. Commercial Wound Dressings for the Treatment of Exuding Wounds: An in-Depth Physico-Chemical Comparative Study. Burn. Trauma 2022, 10, tkac024.
380.
Sopata, M.; Piasecki, A.; Sopata, M. Scanning Electron Microscopic Examination of Absorption Potency of Various Fibrous Dressings. J. Wound Care 2019, 28, 82–88.
381.
Hurlow, J. AQUACEL® Ag Dressing with Hydrofiber® Technology. Adv. Wound Care 2012, 1, 104–107.
382.
Kwon, K.A.; Shipley, R.J.; Edirisinghe, M.; Ezra, D.G.; Rose, G.E.; Rayment, A.W.; Best, S.M.; Cameron, R.E. Microstructure and Mechanical Properties of Synthetic Brow-Suspension Materials. Mater. Sci. Eng. C 2014, 35, 220–230.
383.
Sun, H.; Cheng, Z.; Guo, X.; Gu, H.; Tang, D.; Wang, L. Comparison of Biomechanical and Microstructural Properties of Aortic Graft Materials in Aortic Repair Surgeries. J. Funct. Biomater. 2024, 15, 248.
384.
Herten, M.; Bisdas, T.; Knaack, D.; Becker, K.; Osada, N.; Torsello, G.B.; Idelevich, E.A. Rapid In Vitro Quantification of S. Aureus Biofilms on Vascular Graft Surfaces. Front. Microbiol. 2017, 8, 2333.
385.
Abhari, R.E.; Snelling, S.J.B.; Augustynak, E.; Davis, S.; Fischer, R.; Carr, A.J.; Mouthuy, P.A. A Hybrid Electrospun-Extruded Polydioxanone Suture for Tendon Tissue Regeneration. Tissue Eng. Part A 2024, 30, 214–224.
386.
Shiga, T.; Okada, H.; Isobe, M.; Furui, T. Tissue Damage between Barbed Suture and Conventional Sutures in Animal Laboratory Model Using Scanning Electron Microscopy. J. Obs. Gynaecol. 2024, 44, 2370973.
387.
Dragovic, M.; Pejovic, M.; Stepic, J.; Colic, S.; Dozic, B.; Dragovic, S.; Lazarevic, M.; Nikolic, N.; Milasin, J.; Milicic, B. Comparison of Four Different Suture Materials in Respect to Oral Wound Healing, Microbial Colonization, Tissue Reaction and Clinical Features—Randomized Clinical Study. Clin. Oral. Investig. 2019, 24, 1527–1541.
388.
Andrade, M.G.S.; Weissman, R.; Reis, S.R.A. Tissue Reaction and Surface Morphology of Absorbable Sutures after in Vivo Exposure. J. Mater. Sci. Mater. Med. 2006, 17, 949–961.
389.
Tomihata, K.; Suzuki, M.; Ikada, Y. The PH Dependence of Monofilament Sutures on Hydrolytic Degradation. J. Biomed. Mater. Res. 2001, 58, 511–518.
390.
Lee, K.H.; Chu, C.C. The Role of Superoxide Ions in the Degradation of Synthetic Absorbable Sutures. J. Biomed. Mater. Res. 2000, 49, 25–35.
391.
Jadhav, S.A.; Raval, A.J.; Patravale, V.B. Drug Delivery, Development, and Technological Aspects for Peripheral Drug Eluting Stents. Adv. Drug Deliv. Rev. 2025, 226, 115678.
392.
Pires, L.S.; Melo, D.S.; Borges, J.P.; Henriques, C.R. PEDOT-Coated PLA Fibers Electrospun from Solutions Incorporating Fe(III)Tosylate in Different Solvents by Vapor-Phase Polymerization for Neural Regeneration. Polymers 2023, 15, 4004.
393.
Shahriar, S.M.S.; Sharma, N.; Andrabi Syed, M.; Mondal, B.; Yan, Z.; Rainu, S.; Hellman, A.; Buesquets, M.; Rensch, J.; Perez, R.; et al. Nanofiber, Microfiber, or Hybrid: Which Architecture Excels in Soft Tissue Reinforcement and Constructive Regeneration? ACS Appl. Mater. Interfaces 2026. https://doi.org/10.1021/acsami.6c04938.

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