Aims & Scope

Aims:

Gene Regulation and Signaling (GRS) is an international, peer-reviewed, open access journal dedicated to publishing high-quality research on gene expression, epigenetic regulation, and signaling networks that control cellular communication and inter-organ crosstalk in health and disease. The journal offers a platform for fundamental discoveries as well as translational applications. Besides academic researches, it can also appeal to industrial research efforts. By bridging basic, translational, and clinical research, GRS fosters interdisciplinary dialogue and promotes the integration of molecular biology, systems biology, and clinical sciences. The journal is published quarterly by Scilight Press.

Scope:

The journal welcomes high-quality original works that advance understanding of gene regulation and signaling. GRS publishes original research articles, reviews, perspectives, brief communications, and other formats that highlight emerging concepts and methodologies. Topics of interest include, but are not limited to:

  • Gene expression regulation – transcriptional control, post-transcriptional regulation, non-coding RNAs, RNA processing.
  • Epigenetic mechanisms – DNA methylation, histone modifications, chromatin remodeling, and heritable gene expression changes.
  • Chromatin architecture and nuclear events – 3D genome organization, nuclear dynamics, transcriptional hubs.
  • Signaling factors and pathways – growth factors, cytokines, kinases, phosphatases, signaling cascades.
  • Receptors and cross-talk – membrane receptors, nuclear receptors, ligand-receptor interactions, intercellular communication.
  • Genetic and epigenetic disorders – cancer, metabolic and neurodegenerative diseases, developmental syndromes, rare diseases.
  • Structural and functional studies – protein and RNA complexes in regulation and signaling.
  • Translational and clinical research – mechanisms of pathogenesis, biomarkers, therapeutic targets, clinical interventions.
  • Drug discovery and biotechnology – small molecules, biologics, genome editing, therapeutic strategies targeting regulatory and signaling networks.
  • Emerging technologies – CRISPR and other genome engineering tools, high-resolution imaging, single-cell and spatial transcriptomics.

GRS encourages interdisciplinary submissions that connect molecular mechanisms to systems-level functions, with emphasis on studies integrating structural biology, computational biology, and clinical insights to advance disease intervention and precision medicine.