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Coronary Microvascular Dysfunction: A Potential Intervention Strategy against Acute Myocardial Infarction
  • Zihan Wang 1,   
  • Lianhua Fang 1,   
  • Yang Lv 2,   
  • Shoubao Wang 1, *,   
  • Guanhua Du 1, *

Received: 26 Aug 2024 | Revised: 11 Oct 2024 | Accepted: 11 Oct 2024 | Published: 14 Feb 2025

Abstract

Recent studies have illuminated the role of coronary microvascular dysfunction (CMD) as a pivotal contributor to acute myocardial infarction (AMI). Microvascular dysfunction may lead to severe results including microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH), which are associated with poor prognosis. This article reviews the current research on coronary microvascular dysfunction in myocardial infarction reperfusion including the mechanisms, methods and models assessing CMD. This review emphasizes the importance of CMD and proposes potential avenues for future research in this field. Interventions for CMD may pave the way for novel treatment strategies in the management of acute myocardial infarction (AMI).

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10.53941/ijddp.2025.100004
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Volume 4, Issue 1
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Wang, Z.; Fang, L.; Lv, Y.; Wang, S.; Du, G. Coronary Microvascular Dysfunction: A Potential Intervention Strategy against Acute Myocardial Infarction. International Journal of Drug Discovery and Pharmacology 2025, 4 (1), 100004. https://doi.org/10.53941/ijddp.2025.100004.
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