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Open AccessEditorial

Nucleolar Stress: An Emerging Avenue for Cardiovascular Drug Target Identification

Tayyiba Azam, Xin Wang

2026, 5(1): 100007. doi: 10.53941/ijddp.2026.100007

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Open AccessReview

Macrophage Metabolic Reprogramming and Its Role in Heart Diseases

Xingkai Huang, Gangjie Zhu, Shenghang Liu, Yigang Zhong, Hanwen Zhang

2026, 5(1): 100006. doi: 10.53941/ijddp.2026.100006

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Open AccessArticle

Neuroprotective Effects of Active Component Combination from Shengmai San on Cerebral Ischemia Injury

Ling Li, Zhuo Yang, Ze-Kun Chen, Tian-Tian Wei, Peng-Fei Tu, Ying Zhou, Bo-Wen Pan, Ke-Wu Zeng

2026, 5(1): 100005. doi: 10.53941/ijddp.2026.100005

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Open AccessArticle

Anti-Aging Effects of Nitazoxanide in Caenorhabditis elegans and D-Galactose-Induced Accelerated Aging Mice

Xianzhe Wang, Huilin Liu, Xiangchuan Wang, Hongjie Zhang, Xiuping Chen

2026, 5(1): 100004. doi: 10.53941/ijddp.2026.100004

9 Downloaded
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Open AccessReview

Neuroprotective Effects of Carvacrol in Cerebral Ischemia and Hypoxia

Xin-Yang Zhang, Hio-Lam Ho, Zhong-Ping Feng, Hong-Shuo Sun

2026, 5(1): 100003. doi: 10.53941/ijddp.2026.100003

12 Downloaded
57 Viewed
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Open AccessReview

Nucleolus, Nucleolar Stress and Cardiovascular Diseases

Rongqian Xu, Xiaocen Jin, Yan Zhang, Xiaolei Yang, Yunlong Xia

2026, 5(1): 100002. doi: 10.53941/ijddp.2026.100002

17 Downloaded
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Open AccessReview

Natural Products Targeting GLP-1: Insights into Herbal Therapy for Insulin Resistance and Beta-Cell Function

Akshita Vyas, Shraddha Mahajan, Sumeet Dwivedi, Sweta S. Koka, Gajanan N. Darwhekar

2026, 5(1): 100001. doi: 10.53941/ijddp.2026.100001

31 Downloaded
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Open AccessArticle

Enhancing Myocardial Infarction Prediction in Type 2 Diabetes: A Novel Model for Diagnostic and Targeted Treatment

Yanwei Zhang, Yanqing Zhang, Yun Liu, Kun Xu, Yanhong Liu, Wenqian Ye, Jianli Zhao, Yajing Wang

2025, 4(4): 100025. doi: 10.53941/ijddp.2025.100025

40 Downloaded
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Open AccessReview

Nuclear Receptor-Targeted Therapy for Metabolic Dysfunction-Associated Steatotic Liver Disease

Yachao Zhou, Zhaojian Liu, Donghai Cui, Xingyun Qi, Huiliang Zhang

2025, 4(4): 100024. doi: 10.53941/ijddp.2025.100024

36 Downloaded
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Open AccessReview

The Role and Therapeutic Potential of ARSB Gene in Tumor Development

Zhiqiang Zhang, Qunlong Jin, LiangJin Zhang, Junyao Wan, Yunfei Gao, Ningning Li, Haitao Wang, Yulong He, Xin Zhong

2025, 4(4): 100023. doi: 10.53941/ijddp.2025.100023

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Open AccessReview

RhoA/ROCK Signaling in Vascular Dysfunction: Emerging Insights and Therapeutic Perspectives

Xiao Du, Weijia Luo, Jiang Chang

2025, 4(4): 100022. doi: 10.53941/ijddp.2025.100022

34 Downloaded
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Open AccessReview

Exploring Pathological Mechanisms and Pharmacological Interventions in Acute Myocardial Infarction and Acute Heart Failure

Gaurang Shah, Anil Kumar Prajapati

2025, 4(4): 100021. doi: 10.53941/ijddp.2025.100021

49 Downloaded
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Open AccessReview

Strategic Engineering of Lipid Drug Carriers for the Treatment of Cancer

Shuyao Lang, Yunqing Li, Yi Kong, Youhai H. Chen

2025, 4(4): 100020. doi: 10.53941/ijddp.2025.100020

31 Downloaded
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Open AccessReview

Finerenone Targeting the Mineralocorticoid Receptor: Therapeutic Potential for Cardiorenal Syndrome

Hairui Zhao, Chunyv Pan, Xiaojing Cai, Manyi Wu, Bowen Qin, Hui Zhang, Hengzhi Du, Junhua Li

2025, 4(4): 100019. doi: 10.53941/ijddp.2025.100019

45 Downloaded
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Open AccessReview

Rho/ROCK Pathway as a Therapeutic Target in Multiple Diseases

Zixiu Cheng, Shannon Erhardt, Jun Wang

2025, 4(3): 100018. doi: 10.53941/ijddp.2025.100018

82 Downloaded
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Open AccessReview

Alkaloids and Their Mechanisms of Action in Cardiovascular Diseases

Anil Kumar Prajapati, Gaurang Shah

2025, 4(3): 100017. doi: 10.53941/ijddp.2025.100017

54 Downloaded
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Open AccessArticle

The Effects and Mechanism of Guilu Bushen Pill in the Treatment of Osteoporosis Model in Ovariectomized Rats

Ximing Peng, Junjie Huang, Peifang Lai, Xiaorong Zhang, Mingdeng Guan, Xin Hu, Yimeng Ma, Meiqi Ji, Haiyan Gong, Chunhong Li, Xiuping Chen, Huaqian Wang

2025, 4(3): 100016. doi: 10.53941/ijddp.2025.100016

26 Downloaded
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Open AccessReview

The Underestimated Diabetic Cardiomyopathy: Its Role in Heart Failure Progression and Implications for Drug Discovery

Felycia Fernanda Hosyanto, Jiang Min, Suxin Luo, Shenglan Yang

2025, 4(3): 100015. doi: 10.53941/ijddp.2025.100015

31 Downloaded
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Open AccessArticle

Preparation of Polysaccharides from Qifuyin and Investigation of Their Anti-Oxidant and Regenerative Effects Based on Planaria

Qingxian Wang, Yuexiao Zou, Shixue Wang, Xiaorui Cheng

2025, 4(3): 100014. doi: 10.53941/ijddp.2025.100014

40 Downloaded
176 Viewed
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Open AccessReview

Current Management of Erectile Dysfunction

Siqi Wang, Haocheng Lin, Yan Zhang, Yahan Liu

2025, 4(3): 100013. doi: 10.53941/ijddp.2025.100013

67 Downloaded
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Open AccessArticle
Analyzing the Structure-Activity Relationship of Necrostain-1 and Its Analogues as RIPK1 Inhibitors on Necroptosis

Huilin Liu, Heng Wang, Haoyi Zheng, Xiuping Chen

2025, 4(2): 100012. doi: 10.53941/ijddp.2025.100012

58 Downloaded
189 Viewed
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Open AccessReview
Targeting Cancer Drug-Tolerant Persister Cells in Minimal Residual Disease

Wei Zhang, Sorayut Chattrakarn, Fuhui Chen, Haobin Chai, Mariana Maranga, Jingwei Zhang

2025, 4(2): 100011. doi: 10.53941/ijddp.2025.100011

97 Downloaded
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Open AccessArticle
Advances in Research on Tibetan Medicine for Improving Cognitive Dysfunction

Tianhao Yu, Ying Yu, Xiaorui Cheng

2025, 4(2): 100010. doi: 10.53941/ijddp.2025.100010

44 Downloaded
161 Viewed
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Open AccessReview
Short QT Syndrome and Drug Treatment: A systematic Literature Review and PRISMA Analysis

Tingting You, Cunjin Luo, Kevin Zhang, Henggui Zhang

2025, 4(2): 100009. doi: 10.53941/ijddp.2025.100009

39 Downloaded
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Open AccessArticle
Comparison of Thromboelastography, Conventional Coagulation Tests and Clotting Time in Preclinical Investigations of Anticoagulant Drugs in Rodents

Xinrong Yang, Boning Huang, Ping Tang, Liuqing Lin, Baoqin Lin

2025, 4(2): 100008. doi: 10.53941/ijddp.2025.100008

45 Downloaded
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Open AccessReview
Exploring Fungi Within the Human Gut Microbiota: Obstacles, Innovations, Therapeutic Applications and Prospects Ahead

Peng Xue, Chao Luo, Jiashu Li, Liang Yang, Yuanyuan Ma

2025, 4(2): 100007. doi: 10.53941/ijddp.2025.100007

41 Downloaded
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Open AccessArticle
Ginsenoside Re Ameliorates Cardiac Hypertrophy by Regulating CaSR-Mediated Signaling Pathway

Panpan Chen, Mubo Liu, Hong Xiao, Ting Luo, Hong Ling, Xiaoyan Chen, Zongli Li, Shangfu Xu, Zheng Li, Jiang Deng

2025, 4(1): 100006. doi: 10.53941/ijddp.2025.100006

33 Downloaded
147 Viewed
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Open AccessReview
Research and Prospects on the Evaluation of Drug Cocrystal Permeability

Shuang Li, Meiru Liu, Dezhi Yang, Li Zhang, Yang Lu, Guanhua Du

2025, 4(1): 100005. doi: 10.53941/ijddp.2025.100005

44 Downloaded
140 Viewed
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Open AccessReview
Coronary Microvascular Dysfunction: A Potential Intervention Strategy against Acute Myocardial Infarction

Zihan Wang, Lianhua Fang, Yang Lv, Shoubao Wang, Guanhua Du

2025, 4(1): 100004. doi: 10.53941/ijddp.2025.100004

48 Downloaded
175 Viewed
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Open AccessArticle
Maternal Nutrient Restriction Confers Myocardial Remodeling in Association with Dampened Autophagy and Mitophagy in Adult Sheep Offspring

Wei Ge, Qiurong Wang, Jun Tao, Stephen P. Ford, Wei Guo, Xiaoming Wang, Jun Ren

2025, 4(1): 100003. doi: 10.53941/ijddp.2025.100003

23 Downloaded
99 Viewed
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Open AccessCommunication
Strategizing Cardiovascular Management in Diabetic Patients: Insights and Advancements from the 2023 ESC Guidelines for the Management of Cardiovascular Disease in Patients with Diabetes

Hongyuan Zhang, Darren Green, Yanrong Liu

2025, 4(1): 100002. doi: 10.53941/ijddp.2025.100002

22 Downloaded
111 Viewed
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Open AccessReview
Modeling Arrhythmia in a Dish: An Open View from Human-Engineered Heart Constructs

Shiya Wang, Pengcheng Yang, Jonathan Nimal Selvaraj, Donghui Zhang

2025, 4(1): 100001. doi: 10.53941/ijddp.2025.100001

27 Downloaded
200 Viewed
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Open AccessArticle
Ginsenoside Re Alleviates Oxidative Stress Damage and Ferroptosis in Pulmonary Fibrosis Mice by Regulating the Nrf2/Keap1/GPX4 axis

Huicai Lin, Zhaoqin Wen, Linying Feng, Xiaoyan Chen, Yongxiang Song, Jiang Deng

2024, 3(4): 100025. doi: 10.53941/ijddp.2024.100025

38 Downloaded
95 Viewed
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Open AccessReview
Transverse Tubules in Cardiac Health and Disease: Therapeutic Approaches to T-Tubule Remodelling and Heart Failure Management

Vanya Kalyan

2024, 3(4): 100024. doi: 10.53941/ijddp.2024.100024

18 Downloaded
110 Viewed
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Open AccessReview
Tirzepatide in Treating Metabolic Disorders

Shulin Wei, Suowen Xu

2024, 3(4): 100023. doi: 10.53941/ijddp.2024.100023

14 Downloaded
108 Viewed
1 Cited
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Open AccessReview
Immune Checkpoints Are New Therapeutic Targets in Regulating Cardio-, and Cerebro-Vascular Diseases and CD4+Foxp3+ Regulatory T Cell Immunosuppression

Ying Shao, William Y. Yang, Gayani Nanayakkara, Fatma Saaoud, Mohammed Ben Issa, Keman Xu, Yifan Liu, Xiaohua Jiang, Sadia Mohsin, Hong Wang, Xiaofeng Yang

2024, 3(4): 100022. doi: 10.53941/ijddp.2024.100022

15 Downloaded
90 Viewed
4 Cited
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Open AccessReview
The Role of Autophagy in Heart Disease

Osman Mohiuddin, Sabu Abraham, Hongyuan Zhang, Andrea Ruiz-Velasco

2024, 3(4): 100021. doi: 10.53941/ijddp.2024.100021

17 Downloaded
107 Viewed
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Open AccessReview
Adrenergic Regulation of Cardiac Macrophages: Heterogeneity, Plasticity, and Therapeutic Potential

Wenjing Xiang, Mianli Wang, Hualong Yu, Haocheng Lu, Ying Wang

2024, 3(4): 100020. doi: 10.53941/ijddp.2024.100020

33 Downloaded
106 Viewed
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Open AccessReview
Metabolomics in Cardiovascular Diseases

Shan Lu, Zisheng Huang, Baitao Liu, Yan Zhang

2024, 3(4): 100019. doi: 10.53941/ijddp.2024.100019

23 Downloaded
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Open AccessReview
Molecular and cellular contributors of Rheumatoid Arthritis

Qingxin Bang, Weihua Song, Xiaomeng Wang

2024, 3(3): 100018. doi: 10.53941/ijddp.2024.100018

19 Downloaded
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Open AccessReview
Human Cardiac Organoids: Quantification and Qualification in Cardiovascular Studies

Yingjuan Liu, Sabu Abraham, Honglin Xu

2024, 3(3): 100017. doi: 10.53941/ijddp.2024.100017

28 Downloaded
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Open AccessReview
Unraveling the Roles of HIF-1, HO-1, GLUT-1 and GLUT-4 in Myocardial Protection

Lionel Chong, Nicholas Dushaj, Ani Rakoubian, Johnathan Yarbro, Satoru Kobayashi, Qiangrong Liang

2024, 3(3): 100016. doi: 10.53941/ijddp.2024.100016

20 Downloaded
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2 Cited
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Open AccessReview
Proteolysis Targeting Chimeras (PROTACs): An Innovative Strategy for Targeted Protein Degradation and Disease Treatment

Jun Xia, James K.S. Norris, May-Li MacKinnon, Sam Butterworth

2024, 3(3): 100015. doi: 10.53941/ijddp.2024.100015

39 Downloaded
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Open AccessReview
Detoxification of Paraquat: Scooping up the Moon from the Water?

Yanyan Zhu, Xiuping Chen

2024, 3(3): 100014. doi: 10.53941/ijddp.2024.100014

27 Downloaded
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Open AccessReview
Cell Proliferation and Cytotoxicity Assays, The Fundamentals for Drug Discovery

Jingyi Niu, Minai Li, Ying Wang

2024, 3(3): 100013. doi: 10.53941/ijddp.2024.100013

255 Downloaded
812 Viewed
5 Cited
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Open AccessReview
Brief Version of Chinese Society of Cardiology Guidelines on the Diagnosis and Treatment of Adult Fulminant Myocarditis

Hongyang Shu, Chen Chen, Luyun Wang, Jiangang Jiang, Daowen Wang

2024, 3(3): 100012. doi: 10.53941/ijddp.2024.100012

18 Downloaded
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Open AccessReview
Integrins as Drug Targets in Vascular and Related Diseases

Emily Meredith, Martin A. Schwartz

2024, 3(2): 100010. doi: 10.53941/ijddp.2024.100010

14 Downloaded
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Open AccessReview
The Role of the CREB Signaling Pathway in Tumor Development and Therapeutic Potential

Qunlong Jin, Youheng Jiang, Zhiheng Zhang, Yanming Yang, Zhang Fu, Yunfeng Gao, Ningning Li, Yulong He, Changxue Li

2024, 3(2): 100011. doi: 10.53941/ijddp.2024.100011

49 Downloaded
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Open AccessArticle
Eupatorium Lindleyanum DC. Extract Protects against MPTP-induced Mouse of Parkinson’s Disease by Targeting Neuroinflammation

Yichi Zhang, Lu Yao, Xiaowen Zhang, Zhuo Yang, Yang Chen, Lingli Zheng, Yongzhe Zheng, Wei Yu, Nilufar Z. Mamadalieva, Bo Han, Pengfei Tu, Rimma F. Mukhamatkhanova, Kewu Zeng

2024, 3(2): 100009. doi: 10.53941/ijddp.2024.100009

23 Downloaded
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Open AccessReview
Emerging and Novel Therapeutic Treatments Targeting Mitochondrial-Endoplasmic Reticulum Contact Sites in Metabolic and Vascular Disorders

Richard M. Monaghan

2024, 3(2): 100008. doi: 10.53941/ijddp.2024.100008

34 Downloaded
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