Articles
International Journal of Drug Discovery and Pharmacology
Advances and Prospects of Cardiac Organoids in Drug Development
Xiaoying Liu, Yingjuan Liu, Yutong Yan, Fay Pu, Sam Butterworth, Hongyuan Zhang
2026, doi: 10.53941/ijddp.2026.100022
Sex Differences in HFpEF: Mechanisms, Manifestations, and Therapeutic Target Identification
Yue Lu, Dan Hu, Zihao Ren, Yang Cao
2026, 5(3): 100021. doi: 10.53941/ijddp.2026.100021
Biological Age in Coronary Artery Disease: Advancing Therapeutic Evaluation and Precision Intervention
Ru Sun, Weijian Hang, Ling Zhou, Jia Chen, Chunxia Zhao, Chen Chen, Feng Wang
2026, 5(3): 100020. doi: 10.53941/ijddp.2026.100020
Dental Erosion and Therapeutic Options
Tangmuqi Jiang, Xuya Kang, Yahan Liu, Yan Zhang
2026, 5(3): 100019. doi: 10.53941/ijddp.2026.100019
Unraveling the Mechanism of Higenamine in the Treatment of Right Heart Failure via Computational Drug Discovery and Molecular Simulation Technology
Yujie Qu, Yinghua Huo, Yichen Wang, Xue Yu, Leiyu Tian, Jian Guo, Ling Chen, Yucai Chen
2026, 5(3): 100018. doi: 10.53941/ijddp.2026.100018
Distinct Sex-Specific Characteristics of Apoe Deficient and Ldlr Deficient Mice in Atherosclerosis: Implications for Model Selection and Therapy Development
Yaping Zhao, Li Wang, Bradford C. Berk, Hans Strijdom, Yu Huang, Jianping Weng, Suowen Xu
2026, 5(3): 100017. doi: 10.53941/ijddp.2026.100017
The Role of Autophagy and Potential Drug Targets in Cardiovascular Disease
Vaseega Sathianandan, Tayyiba Azam
2026, 5(3): 100016. doi: 10.53941/ijddp.2026.100016
Caloric Restriction Attenuates Oxidative Injury but Fails to Reverse Established Cardiac Remodeling in Atrial Natriuretic Peptide Receptor 1-Deficient Mice †
Kai Chen, Derek Timm, Yuan Huang, Satoru Kobayashi, Qiangrong Liang
2026, 5(2): 100015. doi: 10.53941/ijddp.2026.100015
Mesenchymal Stem Cells and Their Exosomes in Cardiac Repair: Advances and Future Directions
Zhijun Wang, Na Gao, Jiandong Zhang, Baoqiang Guo
2026, 5(2): 100014. doi: 10.53941/ijddp.2026.100014
Correction: Ge et al. Maternal Nutrient Restriction Confers Myocardial Remodeling in Association with Dampened Autophagy and Mitophagy in Adult Sheep Offspring. Int. J. Drug Discov. Pharmacol. 2025, 4, 100003
Wei Ge, Qiurong Wang, Jun Tao, Stephen P. Ford, Wei Guo, Xiaoming Wang, Jun Ren
2026, 5(2): 100013. doi: 10.53941/ijddp.2026.100013
Correction: Xu et al. Oxidized LDL Regulates Endothelin-1 and Oxidative Stress in Vascular Endothelial Cells: Role of Extracellular Regulated Kinase1/2 (ERK1/2). Int. J. Drug Discov. Pharmacol. 2023, 2, 18–29
Haishan Xu, Jinhong Duan, Jun Tao, Wen Wang, Yunqing Wu, Shunling Dai, Jun Ren
2026, 5(2): 100012. doi: 10.53941/ijddp.2026.100012
GPCR Biased Signaling: Conceptual Advancements and Therapeutic Innovation
Supeng Li, Yongyin Huang, Xingsheng Sun, Ao Shen
2026, 5(2): 100011. doi: 10.53941/ijddp.2026.100011
Single-Cell RNA Sequencing: A Powerful Tool for Advancing Precision Oncology Drug Development
Md Atiq Ashhab
2026, 5(2): 100010. doi: 10.53941/ijddp.2026.100010
Myocardial Lipotoxicity in Cardiovascular Diseases: Mechanisms, Therapeutic Strategies, and Drug Target Discovery
Yaxin Xu, Xinrui Li, Lu Fu
2026, 5(2): 100009. doi: 10.53941/ijddp.2026.100009
Mechanism of Action and Target Detection of Danshen & Hawthorn in the Treatment of Non-Alcoholic Fatty Liver Disease Based on Network Pharmacology and Virtual Docking Simulation
Zirong Zhou, Wenxia Tang, Qinghao Jiao, Yaxing Li, Ying Yang, Hui Li, Jie Yu, Songsong Wang
2026, 5(2): 100008. doi: 10.53941/ijddp.2026.100008
Nucleolar Stress: An Emerging Avenue for Cardiovascular Drug Target Identification
Tayyiba Azam, Xin Wang
2026, 5(1): 100007. doi: 10.53941/ijddp.2026.100007
Macrophage Metabolic Reprogramming and Its Role in Heart Diseases
Xingkai Huang, Gangjie Zhu, Shenghang Liu, Yigang Zhong, Hanwen Zhang
2026, 5(1): 100006. doi: 10.53941/ijddp.2026.100006
Neuroprotective Effects of Active Component Combination from Shengmai San on Cerebral Ischemia Injury
Ling Li, Zhuo Yang, Ze-Kun Chen, Tian-Tian Wei, Peng-Fei Tu, Ying Zhou, Bo-Wen Pan, Ke-Wu Zeng
2026, 5(1): 100005. doi: 10.53941/ijddp.2026.100005
Anti-Aging Effects of Nitazoxanide in Caenorhabditis elegans and D-Galactose-Induced Accelerated Aging Mice
Xianzhe Wang, Huilin Liu, Xiangchuan Wang, Hongjie Zhang, Xiuping Chen
2026, 5(1): 100004. doi: 10.53941/ijddp.2026.100004
Neuroprotective Effects of Carvacrol in Cerebral Ischemia and Hypoxia
Xin-Yang Zhang, Hio-Lam Ho, Zhong-Ping Feng, Hong-Shuo Sun
2026, 5(1): 100003. doi: 10.53941/ijddp.2026.100003
Nucleolus, Nucleolar Stress and Cardiovascular Diseases
Rongqian Xu, Xiaocen Jin, Yan Zhang, Xiaolei Yang, Yunlong Xia
2026, 5(1): 100002. doi: 10.53941/ijddp.2026.100002
Natural Products Targeting GLP-1: Insights into Herbal Therapy for Insulin Resistance and Beta-Cell Function
Akshita Vyas, Shraddha Mahajan, Sumeet Dwivedi, Sweta S. Koka, Gajanan N. Darwhekar
2026, 5(1): 100001. doi: 10.53941/ijddp.2026.100001
Enhancing Myocardial Infarction Prediction in Type 2 Diabetes: A Novel Model for Diagnostic and Targeted Treatment
Yanwei Zhang, Yanqing Zhang, Yun Liu, Kun Xu, Yanhong Liu, Wenqian Ye, Jianli Zhao, Yajing Wang
2025, 4(4): 100025. doi: 10.53941/ijddp.2025.100025
Nuclear Receptor-Targeted Therapy for Metabolic Dysfunction-Associated Steatotic Liver Disease
Yachao Zhou, Zhaojian Liu, Donghai Cui, Xingyun Qi, Huiliang Zhang
2025, 4(4): 100024. doi: 10.53941/ijddp.2025.100024
The Role and Therapeutic Potential of ARSB Gene in Tumor Development
Zhiqiang Zhang, Qunlong Jin, LiangJin Zhang, Junyao Wan, Yunfei Gao, Ningning Li, Haitao Wang, Yulong He, Xin Zhong
2025, 4(4): 100023. doi: 10.53941/ijddp.2025.100023
RhoA/ROCK Signaling in Vascular Dysfunction: Emerging Insights and Therapeutic Perspectives
Xiao Du, Weijia Luo, Jiang Chang
2025, 4(4): 100022. doi: 10.53941/ijddp.2025.100022
Exploring Pathological Mechanisms and Pharmacological Interventions in Acute Myocardial Infarction and Acute Heart Failure
Gaurang Shah, Anil Kumar Prajapati
2025, 4(4): 100021. doi: 10.53941/ijddp.2025.100021
Strategic Engineering of Lipid Drug Carriers for the Treatment of Cancer
Shuyao Lang, Yunqing Li, Yi Kong, Youhai H. Chen
2025, 4(4): 100020. doi: 10.53941/ijddp.2025.100020
Finerenone Targeting the Mineralocorticoid Receptor: Therapeutic Potential for Cardiorenal Syndrome
Hairui Zhao, Chunyv Pan, Xiaojing Cai, Manyi Wu, Bowen Qin, Hui Zhang, Hengzhi Du, Junhua Li
2025, 4(4): 100019. doi: 10.53941/ijddp.2025.100019
Rho/ROCK Pathway as a Therapeutic Target in Multiple Diseases
Zixiu Cheng, Shannon Erhardt, Jun Wang
2025, 4(3): 100018. doi: 10.53941/ijddp.2025.100018
Alkaloids and Their Mechanisms of Action in Cardiovascular Diseases
Anil Kumar Prajapati, Gaurang Shah
2025, 4(3): 100017. doi: 10.53941/ijddp.2025.100017
The Effects and Mechanism of Guilu Bushen Pill in the Treatment of Osteoporosis Model in Ovariectomized Rats
Ximing Peng, Junjie Huang, Peifang Lai, Xiaorong Zhang, Mingdeng Guan, Xin Hu, Yimeng Ma, Meiqi Ji, Haiyan Gong, Chunhong Li, Xiuping Chen, Huaqian Wang
2025, 4(3): 100016. doi: 10.53941/ijddp.2025.100016
The Underestimated Diabetic Cardiomyopathy: Its Role in Heart Failure Progression and Implications for Drug Discovery
Felycia Fernanda Hosyanto, Jiang Min, Suxin Luo, Shenglan Yang
2025, 4(3): 100015. doi: 10.53941/ijddp.2025.100015
Preparation of Polysaccharides from Qifuyin and Investigation of Their Anti-Oxidant and Regenerative Effects Based on Planaria
Qingxian Wang, Yuexiao Zou, Shixue Wang, Xiaorui Cheng
2025, 4(3): 100014. doi: 10.53941/ijddp.2025.100014
Current Management of Erectile Dysfunction
Siqi Wang, Haocheng Lin, Yan Zhang, Yahan Liu
2025, 4(3): 100013. doi: 10.53941/ijddp.2025.100013
Huilin Liu, Heng Wang, Haoyi Zheng, Xiuping Chen
2025, 4(2): 100012. doi: 10.53941/ijddp.2025.100012
Wei Zhang, Sorayut Chattrakarn, Fuhui Chen, Haobin Chai, Mariana Maranga, Jingwei Zhang
2025, 4(2): 100011. doi: 10.53941/ijddp.2025.100011
Tianhao Yu, Ying Yu, Xiaorui Cheng
2025, 4(2): 100010. doi: 10.53941/ijddp.2025.100010
Tingting You, Cunjin Luo, Kevin Zhang, Henggui Zhang
2025, 4(2): 100009. doi: 10.53941/ijddp.2025.100009
Xinrong Yang, Boning Huang, Ping Tang, Liuqing Lin, Baoqin Lin
2025, 4(2): 100008. doi: 10.53941/ijddp.2025.100008
Peng Xue, Chao Luo, Jiashu Li, Liang Yang, Yuanyuan Ma
2025, 4(2): 100007. doi: 10.53941/ijddp.2025.100007
Panpan Chen, Mubo Liu, Hong Xiao, Ting Luo, Hong Ling, Xiaoyan Chen, Zongli Li, Shangfu Xu, Zheng Li, Jiang Deng
2025, 4(1): 100006. doi: 10.53941/ijddp.2025.100006
Shuang Li, Meiru Liu, Dezhi Yang, Li Zhang, Yang Lu, Guanhua Du
2025, 4(1): 100005. doi: 10.53941/ijddp.2025.100005
Zihan Wang, Lianhua Fang, Yang Lv, Shoubao Wang, Guanhua Du
2025, 4(1): 100004. doi: 10.53941/ijddp.2025.100004
Wei Ge, Qiurong Wang, Jun Tao, Stephen P. Ford, Wei Guo, Xiaoming Wang, Jun Ren
2025, 4(1): 100003. doi: 10.53941/ijddp.2025.100003
Hongyuan Zhang, Darren Green, Yanrong Liu
2025, 4(1): 100002. doi: 10.53941/ijddp.2025.100002
Shiya Wang, Pengcheng Yang, Jonathan Nimal Selvaraj, Donghui Zhang
2025, 4(1): 100001. doi: 10.53941/ijddp.2025.100001
Huicai Lin, Zhaoqin Wen, Linying Feng, Xiaoyan Chen, Yongxiang Song, Jiang Deng
2024, 3(4): 100025. doi: 10.53941/ijddp.2024.100025
Vanya Kalyan
2024, 3(4): 100024. doi: 10.53941/ijddp.2024.100024
Shulin Wei, Suowen Xu
2024, 3(4): 100023. doi: 10.53941/ijddp.2024.100023
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