Identification of a Novel Human Peroxiredoxin-6 (PRDX6) Promoter Region Sequence

Jaewoo Hong; Yasmin Hisham; You Sook Cho

doi:10.53941/jiim.2025.100012

Abstract

Peroxiredoxin-6 (PRDX6) is an oxidative stress response protein with multiple roles under reactive oxygen species (ROS)-mediated conditions. The multifunctional cytoprotective role of the protein PRDX6 is to maintain cellular homeostasis and membrane integrity through intracellular ROS and phospholipid turnover. The PRDX6 promoter region has been reported in several biological regulations because of its key binding sites. However, the human PRDX6 promoter sequence is not yet fully understood. In this study, we discovered and characterized the proximal promoter sequence of human PRDX6. Interestingly, the identified human PRDX6 promoter was about 1 kb shorter than the one reported in the database. Further studies with the new human PRDX6 promoter analysis will help to understand intracellular ROS and phospholipid turnover to maintain cellular homeostasis. This report provides the human PRDX6 proximal promoter sequence.

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