Scilight Press

Designing of selective HDAC2 inhibitors will have less adverse effects and better safety profiles. For HDAC2 selectivity, the coumarin derivatives were designed according to the structural requirement of HDAC2 inhibitors. The designed derivatives were then subjected to docking studies and ADME screening by in silico approach. Results showed that compounds had good binding affinity towards HDAC2 and also had drug likeness property. The results of the study can be used for further structural modifications, synthesis and biological evaluation of selective HDAC2 inhibitors.