Proinflammatory Effects of Obesity in the Progression of Triple Negative Breast Cancer

Samuel E., Adunyah

doi:10.53941/jiim.2025.100002

Open Access

Article

Proinflammatory Effects of Obesity in the Progression of Triple Negative Breast Cancer

Deok-Soo Son^{1, *}

,

Rosa Mistica C. Ignacio¹

,

Jubin Son²

,

Eun-Sook Lee³

,

Samuel E. Adunyah¹

Author Information

Submitted: 21 Aug 2024 | Revised: 28 Oct 2024 | Accepted: 2 Dec 2024 | Published: 14 Feb 2025

Abstract

Obesity induces chronic inflammation and is associated with one-fifth of cancer deaths. Triple negative breast cancer (TNBC) has a higher death rate and increased proinflammatory chemokines compared to other breast cancer subtypes. Obesity leads to reduced overall survival in patients with TNBC. Here, we investigated if obesity-induced inflammation is involved in the progression of TNBC using cell line and animal models. Adipocyte-conditioned media (CM) increased cell viability, migration, and proinflammatory chemokines in mouse PY8119 TNBC cells, which reflect well human mesenchymal-like TNBC cells, compared to preadipocyte-CM. The ob/ob mice enhanced the progression of PY8119 cells by increasing the intensity of bioluminescence imaging, tumor volume and weight, and proinflammatory chemokines, compared to the wild-type mice. Furthermore, the immune contexture showed the higher levels of macrophage and CD4 cells in tumors of obese mice. Taken together, obesity may accelerate the progression of TNBC, revealing increased proinflammatory chemokines and altered immune contexture in the tumor microenvironment.

Keywords

triple negative breast cancer | obesity | adipocytes | chemokines

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DOI

10.53941/jiim.2025.100002

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Volume 1, Issue 1

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Son, D.-S., Ignacio, R. M. C., Son, J., Lee, E.-S., & Adunyah, S. E. (2025). Proinflammatory Effects of Obesity in the Progression of Triple Negative Breast Cancer. Journal of Inflammatory and Infectious Medicine, 1(1), 2. https://doi.org/10.53941/jiim.2025.100002

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