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https://doi.org/10.53941/hm.2024.100004
Sui, X., Wu, M., Yang, X., & Wang, Y. The Multifaced Roles of Hepatic Macrophages in MASLD. Health and Metabolism. 2024, 1(1), 4. doi: https://doi.org/10.53941/hm.2024.100004
Volume 1, Issue 1, Dec 2024
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Review

The Multifaced Roles of Hepatic Macrophages in MASLD

Xiaoping Sui 1, Minqi Wu 1, Xue Yang 1 and Yanan Wang 1,2,*

1 Med-X Institute, Center for Immunological and Metabolic Diseases, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an Jiaotong University, Xi’an, 710061, China

2 Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an Jiaotong University, Xi’an, 710061, China

* Correspondence: yanan.wang@xjtu.edu.cn; Tel.: +86-29-8532-3338

Received: 20 September 2024; Revised: 14 October 2024; Accepted: 24 October 2024; Published: 29 October 2024

Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming the leading cause of chronic liver disease-related morbidity and mortality globally. It encompasses a spectrum from metabolic dysfunction-associated steatotic liver (MASL) to metabolic dysfunction-associated steatohepatitis (MASH), potentially advancing to cirrhosis and hepatocellular carcinoma. While the pathogenesis of MASLD is complicated and not yet completely elucidated, hepatic macrophages, including liver resident Kupffer cells (Res-KCs) and recruited circulating monocyte-derived macrophages (MoDMs), play a pivotal role in its initiation and progression. Recent advancements in single-cell RNA sequencing have unveiled significant heterogeneity among macrophages and their diverse contributions to MASLD progression. This review delineates the origin and surface markers of hepatic macrophages, emphasizing their multifaceted roles in the pathogenesis of MASLD in steatosis, inflammation and fibrosis. Furthermore, we delve into the latest advancements in pharmacological treatment strategies for patients with MASLD.

Keywords:

metabolic dysfunction-associated steatotic liver disease macrophage resident Kupffer cell monocyte-derived macrophage therapy

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