Articles

Articles

Open AccessArticle

Structural and Biochemical Analysis of Human Schlafen5 Reveals the Molecular Basis of Its Anti-Tumor Function

Jin-Yu Yang, Jun-Ying Ou, Meng Luo, Zi-Wen Wang, Yong-Qiang Zheng, Ze-Xian Liu, Song Gao

2026, 3(3): 7. doi: 10.53941/hm.2026.100021

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Open AccessArticle

Loss of Heterozygosity in Chromosome 11q13 Covering MEN1 and AIP Associates with Aggressive Features in Pituitary Tumors

Jiaqi Qiang, Shi Chen, Lin Lu, Yong Yao, Hanze Du, Sheng Jiang, Lian Duan, Huijuan Zhu, Hui Pan

2026, 3(3): 6. doi: 10.53941/hm.2026.100020

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Open AccessArticle

Associations of Obesity and Hypertension with Health-Related Physical Fitness among Women Living in Tibet: A Cross-Sectional Study

Ting Chen, Jiaqiao Zhang, Xin Zhao, Jiajuan Wang, Xiaocan Li, Yaohan Peng, Dandan Jia

2026, 3(3): 4. doi: 10.53941/hm.2026.100018

14 Downloaded
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Open AccessReview

Advances in Clinical Applications of 1H NMR-Based Urine Metabolomics

Qiong Yang, Zhou Zhou, Ya-Hui Lin

2026, 3(3): 3. doi: 10.53941/hm.2026.100017

23 Downloaded
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Open AccessReview

The Mechano-Metabolic Adaptability Program in Cancer: From Physical Forces to Malignant Progression

Yuan-Yuan Xin, Wen Li, Ming-Zhu Jin, Wei-Lin Jin

2026, 3(3): 2. doi: 10.53941/hm.2026.100016

50 Downloaded
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Open AccessReview

Antibody Therapy Targeting GP in Treatment of Ebola Virus Infection

Jiazhao Gao, Sandra Chiu, Rui Gong

2026, 3(3): 1. doi: 10.53941/hm.2026.100015

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Open AccessArticle

Gamma-Glutamyl Hydrolase (GGH) Overexpression in Luminal B Breast Cancer: A New Marker of Aggression and a Therapeutic Target

Radjaa Regad, Amina Belhadj, Sonia Amel Sedikki, Sabrina Khelifa, Zakaria Merad, Sarah Hayat Bouasaba, Tewfik Sahraoui

2026, 3(2): 7. doi: 10.53941/hm.2026.100014

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Open AccessOpinion

Inflammatory Bursts as Stochastic Triggers in Cancer Initiation

Xiuli Zhang, Qingshui Wang, Yao Lin

2026, 3(2): 6. doi: 10.53941/hm.2026.100013

45 Downloaded
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Open AccessReview

Artificial Intelligence Empowers Monitoring, Assessment, and Management in Exercise

Min Zhu, Yuhuai Guo, Mingliang Zhao, Tao Sun, Rengfei Shi, Xiaojiao Zheng, Tianlu Chen

2026, 3(2): 5. doi: 10.53941/hm.2026.100012

61 Downloaded
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Open AccessReview

Iron-Dependent Regulation of Tryptophan Metabolism in Depression

Yan Zhang, Jinping Liu, Mingqian Fang, Ren Lai

2026, 3(2): 4. doi: 10.53941/hm.2026.100011

38 Downloaded
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Open AccessReview

Interplay between Gut Microbiome, Metabolites, and Tumor Immunity: Mechanisms and Clinical Translation

Zhen Zhang, Yongchao Gao, Fengyan Yuan, Quanlin Wang, Wei Zhang, Rong Liu

2026, 3(2): 3. doi: 10.53941/hm.2026.100010

41 Downloaded
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Open AccessReview

Mitochondria in Cardiac Disease: Mechanisms, Therapeutic Targets, and Clinical Progress

Edric X. Zhang, Lucas J. Wang, Shen Hu

2026, 3(2): 2. doi: 10.53941/hm.2026.100009

66 Downloaded
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Open AccessReview

NLRP3 Inflammasome: A Potential Therapeutic Target for Atherosclerosis

Mengqi Wang, Jun Cheng, Fen Feng, Linxi Chen

2026, 3(2): 1. doi: 10.53941/hm.2026.100008

59 Downloaded
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Open AccessReview

Monocytes, Macrophages, and Exercise Prescription: A New Frontier in Immunomodulation

Tan Zhang, Li-Hao Huang

2026, 3(1): 7. doi: 10.53941/hm.2026.100007

84 Downloaded
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Open AccessReview

Progress in Henipavirus Neutralizing Antibody for Therapeutic Development

Junping Hong, Yuanteng Zhao, Ethan H. Zhou, Eleni Kourlas, Zhangfei Shen, Kai Xu

2026, 3(1): 6. doi: 10.53941/hm.2026.100006

125 Downloaded
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Open AccessReview

GLP-1 Receptor Agonists for Weight Control: Emerging Insights from Clinical Trials and Future Perspectives

Jiayao Lv, Shiyi Zhang, Yizhe Qu, Youshen Cao, Jiayi Zhang, Xiaoshuang Dai, Lin Shi

2026, 3(1): 5. doi: 10.53941/hm.2026.100005

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2 Cited
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Open AccessReview

Enabling Live Single-Cell Metabolomics: Mass Spectrometry Technologies and Functional Applications

Simin Cheng, Danni Wu, Xiaoxiao Ma, Xiaoyun Gong

2026, 3(1): 4. doi: 10.53941/hm.2026.100004

111 Downloaded
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Open AccessArticle

Multi-Omics Analysis Reveals Crosstalk between Signaling and Metabolic Reprogramming during Celastrol-Mediated Inflammatory Response

Guangshan Xie, Lin Zhu, Xin Diao, Xiuli Su, Li Zhong, Zongwei Cai

2026, 3(1): 3. doi: 10.53941/hm.2026.100003

64 Downloaded
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Open AccessReview

A Narrative Review of Sarcopenic Obesity in the Elderly: Pathogenesis and Treatment Strategies

Haiwang Shi, Tao Wu, Rui Duan

2026, 3(1): 2. doi: 10.53941/hm.2026.100002

84 Downloaded
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1 Cited
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Open AccessReview

Applications of HP-CIL Metabolomics Technology: Advances and Future Perspectives

Jia Li, Cheng Chen, Xingyu Wang, Xi Chen, Jingjing Zhan, Shuang Zhao, Liang Li

2026, 3(1): 1. doi: 10.53941/hm.2026.100001

46 Downloaded
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Open AccessReview

Diverse Mechanisms of Saturated Fatty Acids in Cardiovascular Disease

Xiaoshan Huang, Dawit Adisu Tadese, Qiumin Lu, Ren Lai

2025, 2(4): 9. doi: 10.53941/hm.2025.100032

82 Downloaded
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Open AccessReview

Targeting Inflammatory Cytokines in Autoimmune Diseases: Mechanisms and Therapeutic Advances with Antibody-Based Therapies

Jun Liang, Xiaolei Zhou, Longguang Jiang

2025, 2(4): 8. doi: 10.53941/hm.2025.100031

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3 Cited
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Open AccessArticle

An Observational Study on the Associations between Arterial Stiffness and Health-Related Physical Fitness in Young Adults

Long-Long Liu, Jing Zhang, Qian Xie, Yuan Zhou, Bo Ye, Wan-Wan Wang, Wen-Xin Wei, Liang-Liang Yan, Xiao-Long Li

2025, 2(4): 7. doi: 10.53941/hm.2025.100030

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Open AccessArticle

Moderate, Rather than Vigorous Exercise Improves Plasma Amino Acid Profiles in Patients with Nonalcoholic Fatty Liver Disease

Jia Li, Weijuan Su, Caoxin Huang, Zheng Chen, Shunhua Wang, Yan Zhao, Zhong Chen, Xiulin Shi, Xuejun Li

2025, 2(4): 5. doi: 10.53941/hm.2025.100028

43 Downloaded
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Open AccessReview

Riboswitch Dynamics and Their Expanding Biotechnological Applications

Dian Chen, Yu Liu

2025, 2(4): 4. doi: 10.53941/hm.2025.100027

72 Downloaded
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2 Cited
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Open AccessReview

Fermented Foods Strengthen Immunity against Viral Infections

Xiaoqian Zhou, Binyu Cui, Xiaoyu Wang, Aman Khan, Weidong Wang

2025, 2(4): 3. doi: 10.53941/hm.2025.100026

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Open AccessReview

In Vivo Electrochemical Biosensors: Technology and Personalized Medicine Go Hand in Hand

Yuxin Lou, Siting Chen, Shijin Peng, Fei Lan, Zhuowei Gao, Ye Zhang, Min Luo

2025, 2(4): 2. doi: 10.53941/hm.2025.100025

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Open AccessReview
Autophagy: A Major Regulatory Factor in Glucose Metabolism

Meiqing Liu, Xuling Luo, Haoliang Hu, Linxi Chen

2025, 2(4): 1. doi: 10.53941/hm.2025.100024

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Open AccessArticle
A Sialic Acid-Caged Generic Platform for Sialoengineering of Tumors with Artificial Immuno-Ligand

Shuo Zhang, Huiling Dong, Shixiong Wen, Zejing Lin, Xuanjun Wu, Jiahuai Han, Shoufa Han

2025, 2(3): 8. doi: 10.53941/hm.2025.100023

142 Downloaded
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Open AccessReview
From Liver to Muscle: Crosstalk Mechanisms and Interventions in Sarcopenia

Qiquan Wang, Meng Yao, Xiang Wang, Xinqiang Lan, Gailing Fan, Yang Xiang

2025, 2(3): 7. doi: 10.53941/hm.2025.100022

116 Downloaded
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Open AccessReview
Cas9 Cis/Trans Cleavage Mechanisms: Cross-System CRISPR Insights and Diagnostic Applications

Xueying Li, Ying Chen, Linglong Huang, Jiyun Chen, Liang Liu

2025, 2(3): 6. doi: 10.53941/hm.2025.100021

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1 Cited
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Open AccessArticle
Comparative Study on Metabolic Regulation of SAP Deletion in Normal Mice and Atherosclerotic Mice

Yifan Zhu, Shuhan Xie, Hailong Shu, Yiqing Lu, Jiawei Guo, Qian Li, Yongli Zhang, Yongxia Yang

2025, 2(3): 5. doi: 10.53941/hm.2025.100020

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Open AccessReview
Gastrointestinal Microbial Involvement in Gallstone Formation: A Systematic Review

Sirui Wan, Kun Xia, Yunpeng Liu, Hongzhi Xu

2025, 2(3): 3. doi: 10.53941/hm.2025.100018

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Open AccessArticle
Metabolomics and Lipidomics Study Reveals Metabolic Dysregulation in Epididymal Adipose Tissue of db/db Mice

Yi Ru, Li Xiang, Qing Shen, Xiuli Su, Aimin Xu, Zongwei Cai

2025, 2(3): 1. doi: 10.53941/hm.2025.100016

65 Downloaded
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Open AccessReview
Pathogenic Mechanisms and Treatment Advancements of Sjogren’s Syndrome

Derica C. Tang, Shen Hu

2025, 2(2): 8. doi: 10.53941/hm.2025.100015

68 Downloaded
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Open AccessReview
Application of LLMs/Transformer-Based Models for Metabolite Annotation in Metabolomics

Yijiang Liu, Feifan Zhang, Yifei Ge, Qiao Liu, Siyu He, Xiaotao Shen

2025, 2(2): 7. doi: 10.53941/hm.2025.100014

183 Downloaded
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9 Cited
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Open AccessReview
The Metabolic Underpinnings of Retinal Health and Disease: A Focus on Photoreceptor Cells

Jianbo Jin, Qiuping Liu, Cheng Li

2025, 2(2): 6. doi: 10.53941/hm.2025.100013

54 Downloaded
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Open AccessReview
Strategies for Tag Design and Removal in the Expression and Purification of Recombinant Proteins

Jiayi Xie, Hongyi Fan, Qingshan Bill Fu

2025, 2(2): 4. doi: 10.53941/hm.2025.100011

216 Downloaded
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2 Cited
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Open AccessReview
Targeting Cellular DNA Damage Response in Cancer and Bacterial Infections: Current Progress, Challenges, and Opportunities

Ranxun Lin, Xu Zhang, Qinwei Zhu, Xuening Chen, Lin Dai, Longheng Li, Zuoan Li, Zhonghui Lin

2025, 2(2): 3. doi: 10.53941/hm.2025.100010

40 Downloaded
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1 Cited
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Open AccessArticle
Vascular and Metabolic Responses to Elevated Circulating PDGF-BB in Mice: A Multiparametric MRI Study

Xiuli Yang, Jiekang Wang, Yuguo Li, Mei Wan, Zhiliang Wei

2025, 2(2): 2. doi: 10.53941/hm.2025.100009

66 Downloaded
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9 Cited
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Open AccessReview
From Clinical to Basic Research: The Neuroprotective Effects and Mechanisms of Caffeine

Lijing Wang, Linxi Wang

2025, 2(2): 1. doi: 10.53941/hm.2025.100008

92 Downloaded
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3 Cited
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Open AccessReview
Application of Wearable Devices in Diabetes Management

Zijing Du, Feifan Zhang, Yifei Ge, Yijiang Liu, Honghua Yu, Yong Wang, Rinkoo Dalan, Xiaotao Shen

2025, 2(1): 7. doi: 10.53941/hm.2025.100007

156 Downloaded
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6 Cited
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Open AccessReview
Structural Overview of Herpesvirus Tegument Proteins

Hui-Ping He, Shuang Liao, Dong-Dong Gu, Kun Shi, Song Gao

2025, 2(1): 6. doi: 10.53941/hm.2025.100006

62 Downloaded
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1 Cited
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Open AccessReview
Lifting the Veil on Myeloma Bone Disease

Rui Chen, Rui Liu, Huan Liu

2025, 2(1): 5. doi: 10.53941/hm.2025.100005

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Open AccessReview
AMPK-Mediated Multi-Organ Protective Effects of GLP-1 Receptor Agonists

Xin Wang, Linxi Wang

2025, 2(1): 4. doi: 10.53941/hm.2025.100004

78 Downloaded
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4 Cited
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