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Abstract
The highly pathogenic avian influenza virus H5N1 has garnered global attention due to its high pathogenicity and mortality rates. In recent years, the outbreak of the H5N1 subtype 2.3.4.4b in various mammals has raised concerns about its pandemic potential. This paper reviews the global prevalence and impact of H5N1 virus, explores the current status and challenges in the existing technological platforms for H5N1 vaccine and diagnostic development, and further evaluates the effectiveness and application prospects of current H5N1 therapeutics. This article aims to provide a robust reference to guide the global preparedness for future pandemic potential of avian influenza H5N1.
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