Open Access
Review
Endoplasmic Reticulum Unfolded Protein Responses: Molecular Mechanism and Role in Pathophysiology
Miankun Wu1, †
, Fen Feng2, †
, Jiangang Cao3, *
, Linxi Chen1, *
Author Information
Submitted: 29 Jul 2024 | Revised: 29 Sept 2024 | Accepted: 15 Oct 2024 | Published: 30 Oct 2024
Abstract
To alleviate ER stress, Endoplasmic reticulum unfolded protein responses (ER UPR) is a set of defensive mechanisms that induce the nucleus to decrease protein synthesis due to incorrect protein aggregation in the ER triggered by different pathogenic causes. Overactivation of ER UPR has been linked to a multitude of human disorders, such as autoimmune diseases, malignancies, hypertension, and retinopathy, according to an increasing number of studies. In addition, ER UPR activity prolongs cell life and delays the aging process by preserving the equilibrium of proteins in the endoplasmic reticulum lumen. Furthermore, as described in the literature recently, adaptive activation of ER UPR improves hypertension, obesity, cardiovascular disease, and neurodegenerative illnesses. Targeting ER UPR pathways may be a useful therapeutic approach for treating diabetes, obesity, fatty liver, and neurodegenerative illnesses given the diversity of ER UPR.
Graphical Abstract
Keywords
References
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Volume 1, Issue 1How to Cite
Wu, M., Feng, F., Cao, J., & Chen, L. (2024). Endoplasmic Reticulum Unfolded Protein Responses: Molecular Mechanism and Role in Pathophysiology. Health and Metabolism, 1(1), 6. https://doi.org/10.53941/hm.2024.100006
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