Open Access
Review
Structural Overview of Herpesvirus Tegument Proteins
Hui-Ping He1, 2, *
, Shuang Liao2
, Dong-Dong Gu2
, Kun Shi1
, Song Gao2, *
Author Information
Submitted: 14 Nov 2024 | Revised: 10 Dec 2024 | Accepted: 22 Jan 2025 | Published: 14 Feb 2025
Abstract
Herpesviridae is a family of enveloped double-stranded DNA viruses that cause various diseases in hosts. Among the various components of herpesvirus particles, tegument proteins located between the envelope and nucleocapsid play crucial roles in viral replication, immune evasion, and host-pathogen interactions. Structural studies have unveiled the molecular architecture of tegument proteins, identifying conserved regions and functional domains that serve as therapeutic targets. For example, the immunogenic properties of pp150 have facilitated the development of HCMV vaccines, while structural insights into the BBRF2-BSRF1 complex have guided the design of inhibitors targeting hydrophobic interaction sites essential for viral envelopment. Understanding the three-dimensional structure of herpesvirus tegument proteins would reveal the molecular mechanism underlying the crosstalk with other viral and cellular components, necessitating research into their biological and pathological functions. In this review, we summarize current knowledge on the structural features of herpesvirus tegument proteins, highlighting the structure-based functional implications, including their potential as targets for antiviral drug development.
Graphical Abstract
Keywords
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Volume 2, Issue 1How to Cite
He, H.-P., Liao, S., Gu, D.-D., Shi, K., & Gao, S. (2025). Structural Overview of Herpesvirus Tegument Proteins. Health and Metabolism, 2(1), 6. https://doi.org/10.53941/hm.2025.100006
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