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  • Open Access
  • Review
Gut Microbiota and Their Metabolites as Modulators of Vascular Complications in Diabetes
  • Meng Duan 1, 2, 3, †,   
  • Jielu Wen 1, 2, †,   
  • Anning Chen 1, 2, †,   
  • Sifan Chen 1, 2, *

Received: 08 Nov 2024 | Revised: 29 Nov 2024 | Accepted: 24 Dec 2024 | Published: 07 Jan 2025

Abstract

With the global rise in population and aging, along with the increasing burden of overweight and obesity, the prevalence of diabetes is expected to surge dramatically. Microvascular and macrovascular complications are the leading causes of death among patients with type 2 diabetes. Recent advancements have provided evidence suggesting that gut microbiota directly or indirectly regulate vascular function. This review focuses on the complex interactions between gut microbiota and its metabolites and vascular complications of diabetes. In particular, we highlight the novel therapeutic effects of interventions such as probiotics, dietary modifications, and fecal microbiota transplantation in improving gut microbiota composition and reducing the risk of vascular complications in diabetes. These findings not only provide new insights into the pathological mechanisms of diabetic vascular complications but also reveal ideas for guiding the formulation of future treatment strategies.

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DOI
10.53941/hm.2025.100002
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Volume 2, Issue 1
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Duan, M.; Wen, J.; Chen, A.; Chen, S. Gut Microbiota and Their Metabolites as Modulators of Vascular Complications in Diabetes. Health and Metabolism 2025, 2 (1), 2. https://doi.org/10.53941/hm.2025.100002.
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