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  • Open Access
  • Review
The Metabolic Underpinnings of Retinal Health and Disease: A Focus on Photoreceptor Cells
  • Jianbo Jin 1, 2,   
  • Qiuping Liu 3, *,   
  • Cheng Li 1, 2, 4, *

Received: 27 Oct 2024 | Revised: 09 Dec 2024 | Accepted: 19 Feb 2025 | Published: 14 Apr 2025

Abstract

The photoreceptor cells of the retina, encompassing rods and cones, are pivotal in the transduction of light signals into chemical ones, thereby initiating the visual process. This review explores the metabolic bedrock of these cells, which are not only crucial for preserving retinal health but are also susceptible to metabolic stress, precipitating a spectrum of retinal pathologies. The manuscript elucidates the intricate metabolic processes of photoreceptor cells, the synergistic metabolic interplay between photoreceptors and the retinal pigment epithelium (RPE), and appraises the metabolic shifts within photoreceptor cells under conditions of photic injury and diverse pathological states, as well as the ramifications of these metabolic perturbations for retinal function. The review culminates with a prospective horizon scan of research in photoreceptor cell metabolism, charting anticipated investigative trajectories.

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DOI
10.53941/hm.2025.100013
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Volume 2, Issue 2
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Jin, J.; Liu, Q.; Li, C. The Metabolic Underpinnings of Retinal Health and Disease: A Focus on Photoreceptor Cells. Health and Metabolism 2025, 2 (2), 6. https://doi.org/10.53941/hm.2025.100013.
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