Open Access
Review
Recent Advances in Natural Plant-based Treatment of Myocardial Ischemia-reperfusion Injury
Peixun Yang1, 3, 4
, Minxuan Liu2, 3, 4
, Xiaoxue Fan3, 4
, Xinzhuang Zhang3, 4
, Liang Cao3, 4
, Zhenzhong Wang3, 4
, Wei Xiao3, 4, *
Author Information
Submitted: 23 Mar 2023 | Accepted: 10 May 2023 | Published: 27 Jun 2023
Abstract
Cardiovascular disease (CDV) is the primary cause of death in the world, and myocardial ischemia (MI) is one of the high-risk CVDs. The myocardial blood supply must be restored as soon as possible to reduce the mortality risk, however, reperfusion itself paradoxically leads to further death of cardiomyocytes and increases the infarct size; this is known as myocardial ischemia/reperfusion injury (MIRI). The pathological mechanism of MIRI is complex, and current research mainly focuses on oxidative stress, dysfunctional mitochondrial energy metabolism, Ca 2+ overload, endoplasmic reticulum stress (ERs) and the inflammatory response. This review briefly summarizes the mechanism of MIRI, and natural plant product (NPP) components proven to ameliorate MIRI and their related signaling pathways. NPPs can alleviate MIRI by regulating oxidative stress, inflammation, ERs, Ca 2+ overload and mitochondrial function maintenance. This review will deepen our understanding of how NPPs reduce MIRI and the future value of NPPs in cardio-protection.
Keywords
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Volume 2, Issue 2How to Cite
Yang, P., Liu, M., Fan, X., Zhang, X., Cao, L., Wang, Z., & Xiao, W. (2023). Recent Advances in Natural Plant-based Treatment of Myocardial Ischemia-reperfusion Injury. International Journal of Drug Discovery and Pharmacology, 2(2), 21. https://doi.org/10.53941/ijddp.2023.100003
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Peixun Yang, Minxuan Liu, Xiaoxue Fan, Xinzhuang Zhang, Liang Cao, Zhenzhong Wang, Wei Xiao
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