2607004769
  • Open Access
  • Article

PPE-Associated Skin Lesions Among ICU Healthcare Workers: Clinical Characteristics and Anatomical Distribution

  • Anahita Akbari 1,2,   
  • Amir Hossein Siadat  3,   
  • Zahra mollabashi 3,   
  • Sayed Mohsen Hosseini 4,   
  • Fariba Iraji 3,*

Received: 31 May 2026 | Revised: 29 Jul 2026 | Accepted: 30 Jul 2026 | Published: 10 Aug 2026

Abstract

Background: Personal protective equipment (PPE) is essential in intensive care units, especially when caring for patients with severe respiratory infections. At the same time, prolonged use of respirators, gloves, gowns, and face shields, together with frequent hand hygiene, can irritate the skin and weaken the skin barrier. These reactions may affect comfort during long shifts and make continued PPE use more difficult. Objective: This study evaluated the prevalence, clinical characteristics, morphology, symptoms, and anatomical distribution of PPE-associated skin lesions among ICU healthcare workers. Methods: This cross-sectional observational study included physicians and nurses working in respiratory infection ICUs of governmental hospitals affiliated with Isfahan University of Medical Sciences, Iran. Demographic and occupational data were collected using a structured questionnaire. All participants were examined by board-certified dermatologists, and lesion type, morphology, symptoms, and anatomical distribution were recorded. Results: Among 68 ICU healthcare workers, 61 participants (89.7%; 95% CI, 80.0–95.8) had at least one PPE-associated skin lesion. Clinically diagnosed contact dermatitis was the most frequent diagnosis (77.9%), followed by acne (10.3%) and eczema (7.4%). Erythema was the most frequent morphological finding (70.6%), pruritus was the most frequently reported symptom (88.2%), and the hands were the most commonly affected anatomical site (83.8%). Conclusion: PPE-associated skin lesions were common in this regional ICU cohort. Clinically diagnosed contact dermatitis, pruritus, erythema, and hand involvement were the predominant findings. Because the cross-sectional design does not establish causality, these findings should be interpreted as clinically probable occupational associations and require confirmation in larger longitudinal studies.

References 

  • 1.

    Ferrari, C.; Somma, G.; Giovinazzo, V.; et al. The Influence of Occupational Factors on Contact Dermatitis in Symptomatic Healthcare Workers: A Patch Test Study. Diseases 2025, 13, 77. https://doi.org/10.3390/diseases13030077.

  • 2.

    Sari, A.R.P.; Patria, Y.N.; Wiguna, O.R.; et al. Occupational skin dermatoses among health care workers: A review of adverse skin reactions to personal protective equipment. Dermatol. Rep. 2022, 14, 9474.

  • 3.

    Tian, C.; Lovrics, O.; Vaisman, A.; et al. Risk factors and protective measures for healthcare worker infection during highly infectious viral respiratory epidemics: A systematic review and meta-analysis. Infect. Control Hosp. Epidemiol. 2022, 43, 639–650. https://doi.org/10.1017/ice.2021.18.

  • 4.

    Wilder-Smith, A.; Low, J.G. Risk of respiratory infections in health care workers: Lessons on infection control emerge from the SARS outbreak. Southeast Asian J. Trop. Med. Public Health 2005, 36, 481–488.

  • 5.

    Coombes, C.; Arribas-Garcia, P.; Llerena-Delgado, A.; et al. P-355. Skin Lesions and the Use of Personal Protective Equipment in Healthcare Workers from Lima, Peru during the COVID 19 Pandemic. Open Forum Infect. Dis. 2025, 12 (Suppl. 1), ofae631.556. https://doi.org/10.1093/ofid/ofae631.556.

  • 6.

    Keng, B.M.; Gan, W.H.; Tam, Y.C.; et al. Personal protective equipment-related occupational dermatoses during COVID-19 among health care workers: A worldwide systematic review. JAAD Int. 2021, 5, 85–95.

  • 7.

    Montero‐Vilchez, T.; Cuenca‐Barrales, C.; Martinez‐Lopez, A.; et al. Skin adverse events related to personal protective equipment: A systematic review and meta‐analysis. J. Eur. Acad. Dermatol. Venereol. 2021, 35, 1994–2006.

  • 8.

    Sawada, Y. Occupational Skin Dermatitis among Healthcare Workers Associated with the COVID-19 Pandemic: A Review of the Literature. Int. J. Mol. Sci. 2023, 24, 2989. https://doi.org/10.3390/ijms24032989.

  • 9.

    Mossel, R.M.; Naber, R.J.; van Manen, B.C.; et al. The prevalence of hand dermatitis among intensive care unit nurses. Contact Dermat. 2024, 91, 30–37.

  • 10.

    Phua, J.; Weng, L.; Ling, L.; et al. Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations. Lancet Respir. Med. 2020, 8, 506–517. https://doi.org/10.1016/S2213-2600(20)30161-2.

  • 11.

    Altin, L.; Akbiyik, A. Skin problems associated with using of personal protective equipment in COVID-19 intensive care units. Nurs. Crit. Care 2023, 28, 985–995. https://doi.org/10.1111/nicc.12956.

  • 12.

    Lee, H.C.; Goh, C.L. Occupational dermatoses from Personal Protective Equipment during the COVID-19 pandemic in the tropics—A Review. J. Eur. Acad. Dermatol. Venereol. 2021, 35, 589–596. https://doi.org/10.1111/jdv.16925.

  • 13.

    Uthayakumar, A.K.; Panagou, E.; Manam, S.; et al. PPE-associated dermatoses: Effect on work and wellbeing. Future Healthc. J. 2021, 8, e67–e69. https://doi.org/10.7861/fhj.2020-0210.

  • 14.

    Unoki, T.; Sakuramoto, H.; Sato, R.; et al. Adverse Effects of Personal Protective Equipment Among Intensive Care Unit Healthcare Professionals During the COVID-19 Pandemic: A Scoping Review. SAGE Open Nurs. 2021, 7, 23779608211026164. https://doi.org/10.1177/23779608211026164.

  • 15.

    Jose, S.; Cyriac, M.C.; Dhandapani, M. Health Problems and Skin Damages Caused by Personal Protective Equipment: Experience of Frontline Nurses Caring for Critical COVID-19 Patients in Intensive Care Units. Indian J. Crit. Care Med. 2021, 25, 134–139. https://doi.org/10.5005/jp-journals-10071-23713.

  • 16.

    Lin, P.; Zhu, S.; Huang, Y.; et al. Adverse skin reactions among healthcare workers during the coronavirus disease 2019 outbreak: A survey in Wuhan and its surrounding regions. Br. J. Dermatol. 2020, 183, 190–192. https://doi.org/10.1111/bjd.19089.

  • 17.

    Daye, M.; Cihan, F.G.; Durduran, Y. Evaluation of skin problems and dermatology life quality index in health care workers who use personal protection measures during COVID-19 pandemic. Dermatol. Ther. 2020, 33, e14346. https://doi.org/10.1111/dth.14346.

  • 18.

    Foo, C.C.; Goon, A.T.; Leow, Y.H.; et al. Adverse skin reactions to personal protective equipment against severe acute respiratory syndrome--a descriptive study in Singapore. Contact Dermat. 2006, 55, 291–294. https://doi.org/10.1111/j.1600-0536.2006.00953.x.

  • 19.

    Justin, L.Y.S.; Yew, Y.W. Facial dermatoses induced by face masks: A systematic review and meta-analysis of observational studies. Contact Dermat. 2022, 87, 473–484. https://doi.org/10.1111/cod.14203.

  • 20.

    Proietti, I.; Borrelli, I.; Skroza, N.; et al. Adverse skin reactions to personal protective equipment during COVID-19 pandemic in Italian health care workers. Dermatol. Ther. 2022, 35, e15460. https://doi.org/10.1111/dth.15460.

  • 21.

    Yu, J.; Chen, J.K.; Mowad, C.M.; et al. Occupational dermatitis to facial personal protective equipment in health care workers: A systematic review. J. Am. Acad. Dermatol. 2021, 84, 486–494. https://doi.org/10.1016/j.jaad.2020.09.074.

Share this article:
How to Cite
Akbari, A.; Siadat , A. H.; mollabashi, Z.; Hosseini, S. M.; Iraji, F. PPE-Associated Skin Lesions Among ICU Healthcare Workers: Clinical Characteristics and Anatomical Distribution. Translational Insights 2026, 1 (1), 15. https://doi.org/10.53941/ti.2026.100015.
RIS
BibTex
Copyright & License
article copyright Image
Copyright (c) 2026 by the authors.