
Editor-in-Chief: Prof. Francesco M. Marincola, TAM Biosciences, USA; TAM Global, USA.
Translational Insights (TI) is a peer-reviewed biomedical publication dedicated to fostering, expediting, and streamlining the conversion of basic and preclinical discoveries into the seamless delivery of useful therapeutics for the improvement of human health. TI is a broad-reaching journal covering all areas of medical research spanning from biomedical discoveries to clinical applications, exploiting advanced bioinformatics tools such as artificial intelligence and machine learning for target and biomarker discovery. Moreover, TI welcomes innovative epidemiological surveys, assessments of policies and processes relevant to the biomedical ecosystem that identify hurdles to efficient clinical testing of promising therapeutics and define strategies to overcome them. TI welcomes submissions within this scope, prioritizing impactful discoveries and providing speedy editorial decisions. More
Expanding Access to Cell and Gene Therapies
David Stroncek, Anh Dinh, Jiaqiang Ren
2026, 1(1): 26. doi: 10.53941/ti.2026.100026
Profound Radiographic and Tumor-Lytic Response of Locally Advanced Pancreatic Adenocarcinoma to a Non-Systemic-Chemotherapy Multimodal Protocol—Fractionated Radiotherapy with Capecitabine Radiosensitization, Intratumoral EpCAM/CD3 Bispecific Antibody, Allogeneic NK and Autologous Lymphocyte Cellular Therapy, and Sequenced Pembrolizumab Following Failure of Conventional Gemcitabine-Based Therapy
Heberto Scharamm, Ricardo Ramos, Alfredo Medina, Yi Ma, Siegmund Schramm, Thomas Ichim, Gregory DiRienzo
2026, 1(1): 25. doi: 10.53941/ti.2026.100025
Is Neuroblastoma A Case of Viral Mimicry Suppression?
Ugo Rovigatti
2026, 1(1): 24. doi: 10.53941/ti.2026.100024
HEK293T Vesicle Lipidomes Retain Core Features of Their Parent Cells
Kyle Peres, Krishna Kishor, Sanjoy K. Bhattacharya
2026, 1(1): 23. doi: 10.53941/ti.2026.100023
A Humanized HLA-Matched Avatar Model for Preclinical Evaluation of DNA Cancer Vaccines
Erika Salvatori, Lucia Lione, Melanie Paccagnella, Eleonora Pinto, Mariantonina Greco, Emanuele Marra, Giuseppe Roscilli, Gennaro Ciliberto, Luigi Aurisicchio, Antonella Conforti
2026, 1(1): 22. doi: 10.53941/ti.2026.100022

Frailty Index as a Predictor of Migraine Risk Across the Life Course: A Multi-Level Study from Global Spatial Patterns to Individual Longitudinal Associations
Huaiyu Zhou, Shenghui Jin, Haobo Li
2026, 1(1): 21. doi: 10.53941/ti.2026.100021
The FraiLtx Study Protocol: A Prospective, Single-Center Observational Study on Frailty, Systemic Inflammation, and Monocyte Subsets in Liver Transplant Candidates
Ole Sattler, Anja Bosy-Westphal, Gunnar Elke, Amke Caliebe, Christian Peters, Karina Silvana Zitta, Martin Albrecht, Felix Braun, Anna Lulu Homayr
2026, 1(1): 20. doi: 10.53941/ti.2026.100020
In Vivo CAR-T Cell Engineering: Translating Vector Pharmacology into Therapeutic Performance
Jiaqiang Ren, David Stroncek, Anh Dinh
2026, 1(1): 19. doi: 10.53941/ti.2026.100019
Modulated Electro-Hyperthermia in Oncology: Biophysical Selectivity, Immunogenic Cell Death and Clinical Evidence: A Narrative Review of Mechanisms and Their Translational Status
Andras Szasz
2026, 1(1): 18. doi: 10.53941/ti.2026.100018

Narrative Review on “Sirolimus-Coated Balloons in Complex Percutaneous Coronary Intervention: Potential Implications for Chronic Total Occlusion Bifurcations”
Syed Sardar Shah, Safa Amin, Attiq Ur Rehman, Zulkifal
2026, 1(1): 17. doi: 10.53941/ti.2026.100017