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Open AccessReview

Advances and Prospects of Cardiac Organoids in Drug Development

Xiaoying Liu, Yingjuan Liu, Yutong Yan, Fay Pu, Sam Butterworth, Hongyuan Zhang

2026, 5(4): 100022. doi: 10.53941/ijddp.2026.100022

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Open AccessArticle

Unraveling the Mechanism of Higenamine in the Treatment of Right Heart Failure via Computational Drug Discovery and Molecular Simulation Technology

Yujie Qu, Yinghua Huo, Yichen Wang, Xue Yu, Leiyu Tian, Jian Guo, Ling Chen, Yucai Chen

2026, 5(3): 100018. doi: 10.53941/ijddp.2026.100018

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Open AccessReview

The Role of Autophagy and Potential Drug Targets in Cardiovascular Disease

Vaseega Sathianandan, Tayyiba Azam

2026, 5(3): 100016. doi: 10.53941/ijddp.2026.100016

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Open AccessCorrection

Correction: Ge et al. Maternal Nutrient Restriction Confers Myocardial Remodeling in Association with Dampened Autophagy and Mitophagy in Adult Sheep Offspring. Int. J. Drug Discov. Pharmacol. 2025, 4, 100003

Wei Ge, Qiurong Wang, Jun Tao, Stephen P. Ford, Wei Guo, Xiaoming Wang, Jun Ren

2026, 5(2): 100013. doi: 10.53941/ijddp.2026.100013

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Open AccessCorrection

Correction: Xu et al. Oxidized LDL Regulates Endothelin-1 and Oxidative Stress in Vascular Endothelial Cells: Role of Extracellular Regulated Kinase1/2 (ERK1/2). Int. J. Drug Discov. Pharmacol. 2023, 2, 18–29

Haishan Xu, Jinhong Duan, Jun Tao, Wen Wang, Yunqing Wu, Shunling Dai, Jun Ren

2026, 5(2): 100012. doi: 10.53941/ijddp.2026.100012

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Open AccessReview

Single-Cell RNA Sequencing: A Powerful Tool for Advancing Precision Oncology Drug Development

Md Atiq Ashhab

2026, 5(2): 100010. doi: 10.53941/ijddp.2026.100010

31 Downloaded
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Open AccessReview

Myocardial Lipotoxicity in Cardiovascular Diseases: Mechanisms, Therapeutic Strategies, and Drug Target Discovery

Yaxin Xu, Xinrui Li, Lu Fu

2026, 5(2): 100009. doi: 10.53941/ijddp.2026.100009

40 Downloaded
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1 Cited
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Open AccessEditorial

Nucleolar Stress: An Emerging Avenue for Cardiovascular Drug Target Identification

Tayyiba Azam, Xin Wang

2026, 5(1): 100007. doi: 10.53941/ijddp.2026.100007

39 Downloaded
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Open AccessReview

Strategic Engineering of Lipid Drug Carriers for the Treatment of Cancer

Shuyao Lang, Yunqing Li, Yi Kong, Youhai H. Chen

2025, 4(4): 100020. doi: 10.53941/ijddp.2025.100020

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Open AccessReview

Rho/ROCK Pathway as a Therapeutic Target in Multiple Diseases

Zixiu Cheng, Shannon Erhardt, Jun Wang

2025, 4(3): 100018. doi: 10.53941/ijddp.2025.100018

139 Downloaded
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7 Cited
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Open AccessReview

The Underestimated Diabetic Cardiomyopathy: Its Role in Heart Failure Progression and Implications for Drug Discovery

Felycia Fernanda Hosyanto, Jiang Min, Suxin Luo, Shenglan Yang

2025, 4(3): 100015. doi: 10.53941/ijddp.2025.100015

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Open AccessReview
Targeting Cancer Drug-Tolerant Persister Cells in Minimal Residual Disease

Wei Zhang, Sorayut Chattrakarn, Fuhui Chen, Haobin Chai, Mariana Maranga, Jingwei Zhang

2025, 4(2): 100011. doi: 10.53941/ijddp.2025.100011

147 Downloaded
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3 Cited
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Open AccessReview
Short QT Syndrome and Drug Treatment: A systematic Literature Review and PRISMA Analysis

Tingting You, Cunjin Luo, Kevin Zhang, Henggui Zhang

2025, 4(2): 100009. doi: 10.53941/ijddp.2025.100009

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Open AccessArticle
Comparison of Thromboelastography, Conventional Coagulation Tests and Clotting Time in Preclinical Investigations of Anticoagulant Drugs in Rodents

Xinrong Yang, Boning Huang, Ping Tang, Liuqing Lin, Baoqin Lin

2025, 4(2): 100008. doi: 10.53941/ijddp.2025.100008

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Open AccessReview
Research and Prospects on the Evaluation of Drug Cocrystal Permeability

Shuang Li, Meiru Liu, Dezhi Yang, Li Zhang, Yang Lu, Guanhua Du

2025, 4(1): 100005. doi: 10.53941/ijddp.2025.100005

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Open AccessReview
Modeling Arrhythmia in a Dish: An Open View from Human-Engineered Heart Constructs

Shiya Wang, Pengcheng Yang, Jonathan Nimal Selvaraj, Donghui Zhang

2025, 4(1): 100001. doi: 10.53941/ijddp.2025.100001

49 Downloaded
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Open AccessReview
Human Cardiac Organoids: Quantification and Qualification in Cardiovascular Studies

Yingjuan Liu, Sabu Abraham, Honglin Xu

2024, 3(3): 100017. doi: 10.53941/ijddp.2024.100017

46 Downloaded
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2 Cited
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Open AccessReview
Proteolysis Targeting Chimeras (PROTACs): An Innovative Strategy for Targeted Protein Degradation and Disease Treatment

Jun Xia, James K.S. Norris, May-Li MacKinnon, Sam Butterworth

2024, 3(3): 100015. doi: 10.53941/ijddp.2024.100015

61 Downloaded
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Open AccessReview
Cell Proliferation and Cytotoxicity Assays, The Fundamentals for Drug Discovery

Jingyi Niu, Minai Li, Ying Wang

2024, 3(3): 100013. doi: 10.53941/ijddp.2024.100013

384 Downloaded
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18 Cited
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Open AccessReview
Integrins as Drug Targets in Vascular and Related Diseases

Emily Meredith, Martin A. Schwartz

2024, 3(2): 100010. doi: 10.53941/ijddp.2024.100010

27 Downloaded
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3 Cited
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Open AccessReview
Transforming Growth Factor β Signaling Pathway as a Potential Drug Target in Treating Aortic Diseases

Zijie Liu, Tianyu Song, Liping Xie

2024, 3(1): 100003. doi: 10.53941/ijddp.2024.100003

40 Downloaded
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1 Cited
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Open AccessReview
The Role of Macrophages in Orthodontic Tooth Movement: A Review

Weiye Zhao, Hao Xu, Hanwen Zhang, Bin Yan

2023, 2(3): 97-104. doi: 10.53941/ijddp.2023.100008

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Open AccessExpert review
p21-Activated Kinases Present a New Drug Target for Hypertrophic Cardiomyopathy

Yu He, Ming Lei

2023, 2(3): 79-86. doi: 10.53941/ijddp.2023.100006

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2 Cited
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Open AccessReview
Mechanism of Anti-seizure Medications and Emerging Trends in Epilepsy Treatment

Zubin Singh Rana, Reena Suman, Shobi Veleri, Pradeep Punnakkal

2023, 2(2): 1-16. doi: 10.53941/ijddp.2023.100001

121 Downloaded
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12 Cited
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Open AccessReview
Controlled and Targeted Drug Delivery Using Smart Nanovectors

Abou Bakr M. Salama, Yasmin Y. Salem, Tamer M. A. Mohamed

2023, 2(1): 18-25. doi: 10.53941/ijddp.0201010

41 Downloaded
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3 Cited
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Open AccessReview
The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases

Peihua Dong, Yu Huang, Yujie Pu

2023, 2(1): 11-17. doi: 10.53941/ijddp.0201005

16 Downloaded
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2 Cited
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Open AccessReview
Biological Functions and Applications of Exosomes in Drug Research

Mengmeng Fu, Jiapeng Li, Tungalag Battulga, Xiaoxue Li, Ming Xu

2023, 2(1): 85-90. doi: 10.53941/ijddp.0201008

19 Downloaded
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1 Cited
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Open AccessEditorial
Current Progress in Drug Target Identification and Drug Delivery

Xin Wang

2022, 1(1): 1. doi: 10.53941/ijddp.v1i1.214

24 Downloaded
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Open AccessMini Review
Injectable Multifunctional Natural Polymer-Based Hydrogels for the Local Delivery of Therapeutic Agents

Xue Bai, Annalisa Tirella

2022, 1(1): 10. doi: 10.53941/ijddp.v1i1.203

32 Downloaded
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10 Cited
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Open AccessReview
Advances of the Target-Based and Phenotypic Screenings and Strategies in Drug Discovery

Shoubao Wang, Zihan Wang, Lianhua Fang, Yang Lv, Guanhua Du

2022, 1(1): 2. doi: 10.53941/ijddp.v1i1.199

86 Downloaded
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12 Cited
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Open AccessReview
The Hippo Signaling Pathway as a Drug Target in Familial Dilated Cardiomyopathy

Paulina Langa, Beata M. Wolska, R. John Solaro

2022, 1(1): 4. doi: 10.53941/ijddp.v1i1.189

14 Downloaded
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6 Cited
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Open AccessReview
Progress of 3D Organoid Technology for Preclinical Investigations: Towards Human In Vitro Models

Yingjuan Liu, Honglin Xu, Sabu Abraham, Xin Wang, Bernard D. Keavney

2022, 1(1): 9. doi: 10.53941/ijddp.v1i1.188

33 Downloaded
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3 Cited
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Open AccessReview
Nanoparticle-based Drug Delivery System for Post Myocardial Infarction Management

Minxuan Liu, Chiara Ramponi, Xiaoxue Fan, Xinzhuang Zhang, Liang Cao, Zhenzhong Wang, Wei Xiao

2022, 1(1): 11. doi: 10.53941/ijddp.v1i1.171

18 Downloaded
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2 Cited
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