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Open AccessReview

The Role and Therapeutic Potential of ARSB Gene in Tumor Development

Zhiqiang Zhang, Qunlong Jin, LiangJin Zhang, Junyao Wan, Yunfei Gao, Ningning Li, Haitao Wang, Yulong He, Xin Zhong

2025, 4(4): 100023. doi: 10.53941/ijddp.2025.100023

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Open AccessReview

RhoA/ROCK Signaling in Vascular Dysfunction: Emerging Insights and Therapeutic Perspectives

Xiao Du, Weijia Luo, Jiang Chang

2025, 4(4): 100022. doi: 10.53941/ijddp.2025.100022

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Open AccessReview

Exploring Pathological Mechanisms and Pharmacological Interventions in Acute Myocardial Infarction and Acute Heart Failure

Anil Kumar Prajapati, Gaurang Shah

2025, 4(4): 100021. doi: 10.53941/ijddp.2025.100021

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Open AccessReview

Strategic Engineering of Lipid Drug Carriers for the Treatment of Cancer

Shuyao Lang, Yunqing Li, Yi Kong, Youhai H. Chen

2025, 4(4): 100020. doi: 10.53941/ijddp.2025.100020

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Open AccessReview

Finerenone Targeting the Mineralocorticoid Receptor: Therapeutic Potential for Cardiorenal Syndrome

Hairui Zhao, Chunyv Pan, Xiaojing Cai, Manyi Wu, Bowen Qin, Hui Zhang, Hengzhi Du, Junhua Li

2025, 4(4): 1-16. doi: 10.53941/ijddp.2025.100019

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Open AccessReview

Rho/ROCK Pathway as a Therapeutic Target in Multiple Diseases

Zixiu Cheng, Shannon Erhardt, Jun Wang

2025, 4(3): 100018. doi: 10.53941/ijddp.2025.100018

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Open AccessReview

Alkaloids and Their Mechanisms of Action in Cardiovascular Diseases

Anil Kumar Prajapati, Gaurang Shah

2025, 4(3): 100017. doi: 10.53941/ijddp.2025.100017

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Open AccessArticle

The Effects and Mechanism of Guilu Bushen Pill in the Treatment of Osteoporosis Model in Ovariectomized Rats

Ximing Peng, Junjie Huang, Peifang Lai, Xiaorong Zhang, Mingdeng Guan, Xin Hu, Yimeng Ma, Meiqi Ji, Haiyan Gong, Chunhong Li, Xiuping Chen, Huaqian Wang

2025, 4(3): 100016. doi: 10.53941/ijddp.2025.100016

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Open AccessReview

The Underestimated Diabetic Cardiomyopathy: Its Role in Heart Failure Progression and Implications for Drug Discovery

Felycia Fernanda Hosyanto, Jiang Min, Suxin Luo, Shenglan Yang

2025, 4(3): 100015. doi: 10.53941/ijddp.2025.100015

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Open AccessArticle

Preparation of Polysaccharides from Qifuyin and Investigation of Their Anti-Oxidant and Regenerative Effects Based on Planaria

Qingxian Wang, Yuexiao Zou, Shixue Wang, Xiaorui Cheng

2025, 4(3): 100014. doi: 10.53941/ijddp.2025.100014

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Open AccessReview

Current Management of Erectile Dysfunction

Siqi Wang, Haocheng Lin, Yan Zhang, Yahan Liu

2025, 4(3): 100013. doi: 10.53941/ijddp.2025.100013

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Open AccessArticle
Analyzing the Structure-Activity Relationship of Necrostain-1 and Its Analogues as RIPK1 Inhibitors on Necroptosis

Huilin Liu, Heng Wang, Haoyi Zheng, Xiuping Chen

2025, 4(2): 100012. doi: 10.53941/ijddp.2025.100012

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Open AccessReview
Targeting Cancer Drug-Tolerant Persister Cells in Minimal Residual Disease

Wei Zhang, Sorayut Chattrakarn, Fuhui Chen, Haobin Chai, Mariana Maranga, Jingwei Zhang

2025, 4(2): 100011. doi: 10.53941/ijddp.2025.100011

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Open AccessArticle
Advances in Research on Tibetan Medicine for Improving Cognitive Dysfunction

Tianhao Yu, Ying Yu, Xiaorui Cheng

2025, 4(2): 100010. doi: 10.53941/ijddp.2025.100010

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Open AccessReview
Short QT Syndrome and Drug Treatment: A systematic Literature Review and PRISMA Analysis

Tingting You, Cunjin Luo, Kevin Zhang, Henggui Zhang

2025, 4(2): 100009. doi: 10.53941/ijddp.2025.100009

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Open AccessArticle
Comparison of Thromboelastography, Conventional Coagulation Tests and Clotting Time in Preclinical Investigations of Anticoagulant Drugs in Rodents

Xinrong Yang, Boning Huang, Ping Tang, Liuqing Lin, Baoqin Lin

2025, 4(2): 100008. doi: 10.53941/ijddp.2025.100008

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Open AccessReview
Exploring Fungi Within the Human Gut Microbiota: Obstacles, Innovations, Therapeutic Applications and Prospects Ahead

Peng Xue, Chao Luo, Jiashu Li, Liang Yang, Yuanyuan Ma

2025, 4(2): 100007. doi: 10.53941/ijddp.2025.100007

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Open AccessArticle
Ginsenoside Re Ameliorates Cardiac Hypertrophy by Regulating CaSR-Mediated Signaling Pathway

Panpan Chen, Mubo Liu, Hong Xiao, Ting Luo, Hong Ling, Xiaoyan Chen, Zongli Li, Shangfu Xu, Zheng Li, Jiang Deng

2025, 4(1): 100006. doi: 10.53941/ijddp.2025.100006

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Open AccessReview
Research and Prospects on the Evaluation of Drug Cocrystal Permeability

Shuang Li, Meiru Liu, Dezhi Yang, Li Zhang, Yang Lu, Guanhua Du

2025, 4(1): 100005. doi: 10.53941/ijddp.2025.100005

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Open AccessReview
Coronary Microvascular Dysfunction: A Potential Intervention Strategy against Acute Myocardial Infarction

Zihan Wang, Lianhua Fang, Yang Lv, Shoubao Wang, Guanhua Du

2025, 4(1): 100004. doi: 10.53941/ijddp.2025.100004

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Open AccessArticle
Maternal Nutrient Restriction Confers Myocardial Remodeling in Association with Dampened Autophagy and Mitophagy in Adult Sheep Offspring

Wei Ge, Qiurong Wang, Jun Tao, Stephen P. Ford, Wei Guo, Xiaoming Wang, Jun Ren

2025, 4(1): 100003. doi: 10.53941/ijddp.2025.100003

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Open AccessCommunication
Strategizing Cardiovascular Management in Diabetic Patients: Insights and Advancements from the 2023 ESC Guidelines for the Management of Cardiovascular Disease in Patients with Diabetes

Hongyuan Zhang, Darren Green, Yanrong Liu

2025, 4(1): 100002. doi: 10.53941/ijddp.2025.100002

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Open AccessReview
Modeling Arrhythmia in a Dish: An Open View from Human-Engineered Heart Constructs

Shiya Wang, Pengcheng Yang, Jonathan Nimal Selvaraj, Donghui Zhang

2025, 4(1): 100001. doi: 10.53941/ijddp.2025.100001

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Open AccessArticle
Ginsenoside Re Alleviates Oxidative Stress Damage and Ferroptosis in Pulmonary Fibrosis Mice by Regulating the Nrf2/Keap1/GPX4 axis

Huicai Lin, Zhaoqin Wen, Linying Feng, Xiaoyan Chen, Yongxiang Song, Jiang Deng

2024, 3(4): 100025. doi: 10.53941/ijddp.2024.100025

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Open AccessReview
Transverse Tubules in Cardiac Health and Disease: Therapeutic Approaches to T-Tubule Remodelling and Heart Failure Management

Vanya Kalyan

2024, 3(4): 100024. doi: 10.53941/ijddp.2024.100024

12 Downloaded
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Open AccessReview
Tirzepatide in Treating Metabolic Disorders

Shulin Wei, Suowen Xu

2024, 3(4): 100023. doi: 10.53941/ijddp.2024.100023

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1 Cited
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Open AccessReview
Immune Checkpoints Are New Therapeutic Targets in Regulating Cardio-, and Cerebro-Vascular Diseases and CD4+Foxp3+ Regulatory T Cell Immunosuppression

Ying Shao, William Y. Yang, Gayani Nanayakkara, Fatma Saaoud, Mohammed Ben Issa, Keman Xu, Yifan Liu, Xiaohua Jiang, Sadia Mohsin, Hong Wang, Xiaofeng Yang

2024, 3(4): 100022. doi: 10.53941/ijddp.2024.100022

7 Downloaded
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3 Cited
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Open AccessReview
The Role of Autophagy in Heart Disease

Osman Mohiuddin, Sabu Abraham, Hongyuan Zhang, Andrea Ruiz-Velasco

2024, 3(4): 100021. doi: 10.53941/ijddp.2024.100021

11 Downloaded
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Open AccessReview
Adrenergic Regulation of Cardiac Macrophages: Heterogeneity, Plasticity, and Therapeutic Potential

Wenjing Xiang, Mianli Wang, Hualong Yu, Haocheng Lu, Ying Wang

2024, 3(4): 100020. doi: 10.53941/ijddp.2024.100020

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Open AccessReview
Metabolomics in Cardiovascular Diseases

Shan Lu, Zisheng Huang, Baitao Liu, Yan Zhang

2024, 3(4): 100019. doi: 10.53941/ijddp.2024.100019

13 Downloaded
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Open AccessReview
Molecular and cellular contributors of Rheumatoid Arthritis

Qingxin Bang, Weihua Song, Xiaomeng Wang

2024, 3(3): 100018. doi: 10.53941/ijddp.2024.100018

12 Downloaded
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Open AccessReview
Human Cardiac Organoids: Quantification and Qualification in Cardiovascular Studies

Yingjuan Liu, Sabu Abraham, Honglin Xu

2024, 3(3): 100017. doi: 10.53941/ijddp.2024.100017

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Open AccessReview
Unraveling the Roles of HIF-1, HO-1, GLUT-1 and GLUT-4 in Myocardial Protection

Lionel Chong, Nicholas Dushaj, Ani Rakoubian, Johnathan Yarbro, Satoru Kobayashi, Qiangrong Liang

2024, 3(3): 100016. doi: 10.53941/ijddp.2024.100016

12 Downloaded
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1 Cited
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Open AccessReview
Proteolysis Targeting Chimeras (PROTACs): An Innovative Strategy for Targeted Protein Degradation and Disease Treatment

Jun Xia, James K.S. Norris, May-Li MacKinnon, Sam Butterworth

2024, 3(3): 100015. doi: 10.53941/ijddp.2024.100015

24 Downloaded
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Open AccessReview
Detoxification of Paraquat: Scooping up the Moon from the Water?

Yanyan Zhu, Xiuping Chen

2024, 3(3): 100014. doi: 10.53941/ijddp.2024.100014

15 Downloaded
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Open AccessReview
Cell Proliferation and Cytotoxicity Assays, The Fundamentals for Drug Discovery

Jingyi Niu, Minai Li, Ying Wang

2024, 3(3): 100013. doi: 10.53941/ijddp.2024.100013

146 Downloaded
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3 Cited
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Open AccessReview
Brief Version of Chinese Society of Cardiology Guidelines on the Diagnosis and Treatment of Adult Fulminant Myocarditis

Hongyang Shu, Chen Chen, Luyun Wang, Jiangang Jiang, Daowen Wang

2024, 3(3): 100012. doi: 10.53941/ijddp.2024.100012

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Open AccessReview
Integrins as Drug Targets in Vascular and Related Diseases

Emily Meredith, Martin A. Schwartz

2024, 3(2): 100010. doi: 10.53941/ijddp.2024.100010

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Open AccessReview
The Role of the CREB Signaling Pathway in Tumor Development and Therapeutic Potential

Qunlong Jin, Youheng Jiang, Zhiheng Zhang, Yanming Yang, Zhang Fu, Yunfeng Gao, Ningning Li, Yulong He, Changxue Li

2024, 3(2): 100011. doi: 10.53941/ijddp.2024.100011

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Open AccessArticle
Eupatorium Lindleyanum DC. Extract Protects against MPTP-induced Mouse of Parkinson’s Disease by Targeting Neuroinflammation

Yichi Zhang, Lu Yao, Xiaowen Zhang, Zhuo Yang, Yang Chen, Lingli Zheng, Yongzhe Zheng, Wei Yu, Nilufar Z. Mamadalieva, Bo Han, Pengfei Tu, Rimma F. Mukhamatkhanova, Kewu Zeng

2024, 3(2): 100009. doi: 10.53941/ijddp.2024.100009

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Open AccessReview
Emerging and Novel Therapeutic Treatments Targeting Mitochondrial-Endoplasmic Reticulum Contact Sites in Metabolic and Vascular Disorders

Richard M. Monaghan

2024, 3(2): 100008. doi: 10.53941/ijddp.2024.100008

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Open AccessReview
Janus Kinases and Autoimmunity: Bridging Pathways to Therapy

Yazi Wei, Tiantai Zhang

2024, 3(2): 100007. doi: 10.53941/ijddp.2024.100007

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Open AccessReview
Inhibiting the Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Cascade in Cancer and the Heart: for Better or Worse, in Sickness and Health?

Angela Clerk, Shona U Amadi, Samuel J Smith, Peter H Sugden

2024, 3(2): 100006. doi: 10.53941/ijddp.2024.100006

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1 Cited
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Open AccessReview
Breaking Boundaries: Novel Effects of Levosimendan in Various Diseases

Hongyuan Zhang, Minxing Zhao, Yanrong Liu

2024, 3(1): 100005. doi: 10.53941/ijddp.2024.100005

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Open AccessReview
Development of Proteasome Inhibitors for Cancer Therapy

Xu Chen, Xuan Wu, Linyan Li, Xiaoming Zhu

2024, 3(1): 100004. doi: 10.53941/ijddp.2024.100004

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Open AccessReview
Transforming Growth Factor β Signaling Pathway as a Potential Drug Target in Treating Aortic Diseases

Zijie Liu, Tianyu Song, Liping Xie

2024, 3(1): 100003. doi: 10.53941/ijddp.2024.100003

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Open AccessReview
The Application of Artificial Intelligence in the Research and Development of Traditional Chinese Medicine

Zhipeng Ke, Minxuan Liu, Jing Liu, Zhenzhen Su, Lu Li, Mengyu Qian, Xinzhuang Zhang, Liang Cao, Tuanjie Wang, Zhenzhong Wang, Wei Xiao

2024, 3(1): 100001. doi: 10.53941/ijddp.2024.100001

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Open AccessArticle
Mkk7 Protects Against Cardiac Dysfunction in Heart Failure with Preserved Ejection Fraction

Tayyiba Azam, Hongyuan Zhang, Susanne Hille, Oliver J. Müller, Elizabeth J. Cartwright, Xin Wang

2024, 3(1): 100002. doi: 10.53941/ijddp.2024.100002

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Open AccessReview
Bacopa monnieri Extract As a Neuroprotective and Cognitive Enhancement Agent

Bevin J. Nishanth, Princy Vijayababu, Noble K. Kurian

2023, 2(4): 44-56. doi: 10.53941/ijddp.2023.100015

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4 Cited
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Open AccessReview
Hippo Signaling: Advances in Potential Therapeutic Targets for Sinoatrial Node Disorders

Julianna N. Quinn, Jun Wang

2023, 2(4): 36-43. doi: 10.53941/ijddp.2023.100014

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